Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya3374110.26442/00403660.2019.12.000451Research ArticleThe effectiveness of target therapy in patients with severe allergic asthmaSkorokhodkinaO V-ValeevaA R-LuntsovA V-PozdnyakV A-Kazan State Medical UniversityRepublican Clinical Hospital151220199112576216042020Copyright © 2019, Consilium Medicum2019The purpose of study was to analyze own clinical experience and assess the effectiveness in treatment of severe very poorly controlled allergic asthma patients with omalizumab. The effectiveness of biologic treatment with omalizumab was analyzed in 10 patients with severe very poorly controlled allergic asthma. It has been shown that indication of anti-IgE therapy in case of severe allergic asthma resulted in decrease of day and night asthma symptoms, symptoms of allergic rhinitis, dose of other anti - inflammatory asthma medications, discontinuation of systemic corticosteroids which led to good and partial control of the disease. Anti-IgE therapy is a highly effective treatment in asthma patients with atopic phenotype.severe allergic asthmaomalizumabtarget therapyтяжелая бронхиальная астмаомализумабтаргетная терапия[Хаитов Р.М., Ильина Н.И., ред. Аллергология и клиническая иммунология. Клинические рекомендации. М.: ГЭОТАР-Медиа, 2019.][GINA - Global initiative for asthma, 2019. Available at: http://www.gin -asthma.org][Федеральные клинические рекомендации по диагностике и лечению бронхиальной астмы. Российское респираторное общество, 2016.][Инструкция по медицинскому применению препарата омализумаб. Доступно по ссылке: http://grls.rosminzdrav.ru][Княжеская Н.П., Белевский А.С., Осипова Г.Л. Таргетная терапия бронхиальной астмы: в фокусе внимания омализумаб. Практическая пульмонология. 2015;(2):10-6.][Braunstahl G.J., Chen C.W, Maykut R, et al. The real - world effectiveness of omalizumab in allergic asthma: results from the 2-year eXpeRience - registry. Respir Med. 2013;107:1141-51. doi: 10.1016/ j. rmed.2013.04.017][Menzella F, Galeone C, Formisano D, et al. Real - life Efficacy of Omalizumab After 9 Years of Follow - up. Allergy Asthma Immunol Res. 2017 Jul;9(4):368-72. doi: 10.4168/aair.2017.9.4.368]