Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3369410.26442/00403660.2019.08.000378Editorial articleПередовая статьяReview ArticleHypervitaminosis B12 - a new marker and predictor of prognostically unfavorable diseasesГипервитаминоз В12 - новый маркер и предиктор прогностически неблагоприятных заболеванийPodzolkovV IПодзолковВалерий Иванович

д.м.н., проф., зав. каф. факультетской терапии №2 лечебного факультета, директор клиники факультетской терапии УКБ №4; ORCID: 0000-0002-0758-5609

DragomiretskayaN AДрагомирецкаяНаталья Александровна

к.м.н., доц. каф. факультетской терапии №2 лечебного факультета; тел: +7(925)519-56-50; e-mail: dragomiretskayanatalia@mail.ru; ORCID: 0000-0002-6531-6255

dragomiretskaya_natalia@mail.ruDambaevaO TsДамбаеваОльга Цереновна

клинический ординатор каф. факультетской терапии №2 лечебного факультета

AuvinenS TАувиненСини Тамара

студентка

MedvedevI DМедведевИван Дмитриевич

к.м.н., доц. каф. факультетской терапии №2 лечебного факультета; ORCID: 0000-0003-4210-2841

Sechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)15082019918VOL 91, NO8 (2019)ТОМ 91, №8 (2019)16016716042020Copyright ©; 2019, Consilium MedicumCopyright ©; 2019, ООО "Консилиум Медикум"2019Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/33694

A high serum vitamin B12 level (hypercobalaminemia) is a underestimated anomaly. Clinically, it can be paradoxically accompanied by signs of deficiency, which are related to defects in tissue uptake of vitamin B12. The increase in the level of serum cobalamin occurs mainly in serious diseases that require early diagnosis: hemoblastosis, liver and kidney diseases, etc. This review presents data on the metabolism of vitamin B12 and the potential significance of increasing its level as a marker for the early diagnosis of these diseases.

Гиперкобаламинемия - синдром повышения уровня витамина B12 в сыворотке крови, значение которого в клинической практике часто недооценивается. Это явление может сопровождаться парадоксальными с клинической точки зрения признаками гиповитаминоза витамина В12, отражающими наличие функционального дефицита, обусловленного дефектами потребления витамина тканями. Этиологическими факторами повышения уровня кобаламина в сыворотке крови являются преимущественно тяжелые заболевания, при которых особое значение для прогноза имеет ранняя диагностика: солидные опухоли, злокачественные гематологические новообразования, а также заболевания печени и почек с признаками их недостаточности. В настоящем обзоре представлены данные об обмене витамина В12 и потенциальной значимости повышения его уровня как маркера ранней диагностики этих заболеваний.

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