Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3361810.26442/00403660.2019.05.000234Editorial articleПередовая статьяReview ArticlePulmonary hemorrhage in rheumatic diseasesЛегочное кровотечение в практике ревматологаKraevaV VКраеваВалентина Владимировна

к.м.н., ассистент каф. внутренних, профессиональных болезней и ревматологии МПФ ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

BeketovaT VБекетоваТатьяна Валентиновна

д.м.н., в.н.с. ФГБНУ «НИИР им. В.А. Насоновой»

vbek22@rambler.ruI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)V.A. Nasonova Scientific and Research Institute of RheumatologyФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»15052019915VOL 91, NO5 (2019)ТОМ 91, №5 (2019)768316042020Copyright ©; 2019, Consilium MedicumCopyright ©; 2019, ООО "Консилиум Медикум"2019Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/33618

In the article, we report the causes of pulmonary hemorrhage (PH) according to the literature data and own experience, with an emphasis on patients suffering from rheumatic diseases. Methods of diagnosis and modern approaches to the treatment of PH are analyzed.

В представленной статье на основе данных литературы и собственного опыта приведены сведения о причинах легочных кровотечений (ЛК) с акцентом на пациентов, страдающих ревматическими заболеваниями. Проанализированы методы диагностики и современные подходы лечения ЛК.

Hemoptysispulmonary alveolar hemorrhagepulmonary-renal syndromerheumatic diseasesлегочное кровотечениедиффузное альвеолярное кровотечениелегочно-почечный синдромревматические заболеванияIbrahim W.H. Massive haemoptysis: the definition should be revised. Eur Respir J. 2008;32(4):1131-2. doi: 10.1183/09031936.00080108Palade E, Guenter J, Elze M, Wiesemann S, Passlick B. Management of Hemoptysis: Results of an Algorithm-Based Interdisciplinary Treatment Scheme. Zentralbl Chir. 2016;141(1):85-92. doi: 10.1055/s-0035-1545877Swanson K.L, Johnson M, Prakash U.B.S, et al. Bronchial artery embolization: experience with 54 patients. Chest. 2002;121:789-95.Bruzzi J.F, Rémy-Jardin M, Delhaye D, Teisseire A, Khalil C, Rémy J. Multi - detector row CT of hemoptysis. Radiographics. 2006;26(1):3-22. doi: 10.11 48/rg.261045726Yoon Y.C, Lee K.S, Jeong Y.J, Shin S.W, Chung M.J, Kwon O.J. Hemoptysis: bronchial and nonbronchial systemic arteries at 16-detector row CT. Radiology. 2005;234(1):292-8. doi: 10.1148/radiol.2341032079Revel M.P, Fournier L.S, Hennebicque A.S, Cuenod C.A, Meyer G, Reynaud P, Frija G. Can CT replace bronchoscopy in the detection of the site and cause of bleeding in patients with large or massive hemoptysis? AJR Am J Roentgenol. 2002;179(5):1217-24. doi: 10.2214/ajr.179.5.1791217Hsiao E.I, Kirsch C.M, Kagawa F.T, Wehner J.H, Jensen W.A, Baxter R.B. Utility of fiberoptic bronchoscopy before bronchial artery embolization for massive hemoptysis. AJR Am J Roentgenol. 2001;177(4):861-7. doi: 10.2214/ajr.177.4.17 70861Fishbein G.A, Fishbein M.C. Lung vasculitis and alveolar hemorrhage: Pathology. Semin Respir Crit Care Med. 2011;32:254-63. doi: 10.1055/s-0031-1279823Cordier J.F, Cottin V. Alveolar hemorrhage in vasculitis: Primary and secondary. Semin Respir Crit Care Med. 2011;32(3):310-21. doi: 10.1055/s-0031-1279827Krause M.L, Cartin-Ceba R, Specks U, Peikert T. Update on diffuse alveolar hemorrhage and pulmonary vasculitis. Immunol Allergy Clin North Am. 2012;32(4):587-600. doi: 10.1016/j.iac.2012.08.001Nasser M, Cottin V. Alveolar hemorrhage in vasculitis (primary and secondary). Semin Respir Crit Care Med. 2018;39(4):482-93. doi: 10.1055/s-0038-1668533Quadrelli S, Dubinsky D, Solis M, et al. Immune diffuse alveolar hemorrhage: clinical presentation and outcome. Respir Med. 2017;129:59-62. doi: 10.1016/j.rmed.2017.06.003Papiris S.A, Manali E.D, Kalomenidis I, Kapotsis G.E, Karakatsani A, Roussos C. Bench - to - bedside review: pulmonary - renal syndromes--an update for the intensivist. Crit Care. 2007;11(3):213. doi: 10.1186/cc5778Lazar R. Alveolar hemorrhage syndromes. Eur Respir Mon. 2011;54:15-31.Jennette J.C, Falk R.J, Bacon P.A, Basu N, Cid M.C, Ferrario F, Flores-Suarez L.F, Gross W.L, Guillevin L, Hagen E.C, Hoffman G.S, Jayne D.R, Kallenberg C.G, Lamprecht P, Langford C.A, Luqmani R.A, Mahr A.D, Matteson E.L, Merkel P.A, Ozen S, Pusey C.D, Rasmussen N, Rees A.J, Scott D.G, Specks U, Stone J.H, Takahashi K, Watts R.A. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi: 10.1002/art.37715Бекетова Т.В. Алгоритм диагностики системных васкулитов, ассоциированных с антинейтрофильными цитоплазматическими антителами. Терапевтический архив. 2018;90(5):13-21.Cartin-Ceba R, Diaz-Caballero L, Al-Qadi M.O, et al. Diffuse alveolar hemorrhage secondary to antineutrophil cytoplasmic antibody - associated vasculitis: predictors of respiratory failure and clinical outcomes. Arthritis Rheumatol. 2016;68(06):1467-76. doi: 10.1002/art.39562Pedchenko V, Bondar O, Fogo A.V, et al. Molecular architecture of the Gudpasture autoantigen in anti-GBM nephritis. N Engl J Med. 2010;363:343-54. doi: 10.1056/NEJMoa0910500Lazor R, Bigay-Game L, Cottin V, et al. Alveolar hemorrhage in anti - basement membrane antibody disease: a series of 28 cases. Medicine (Baltimore). 2007;86:181-93. doi: 10.1097/md.0b013e318067da56Short A.K, Esnault V.L, Lockwood C.M. Anti - neutrophil cytoplasm antibodies and anti - glomerular basement membrane antibodies: two coexisting distinct autoreactivities detectable in patients with rapidly progressive glomerulonephritis. Am J Kidney Dis. 1995;26:439-45.Levy J.B, Turner A.N, Rees A.J, et al. Long - term outcome of anti - glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. 2001;134:1033-42.Zamora M.R, Warner M.L, Tuder R, Schwarz M.I. Diffuse alveolar hemorrhage and systemic lupus erythematosus. Clinical presentation, histology, survival, and outcome. Medicine (Baltimore). 1997;76(3):192-202.Andrade C, Mendoca T, Farinha F, et al. Alveolar hemorrhage in systemic lupus erythematosus: A cohort review. Lupus. 2016;25(1):75-80. doi: 10.1177/ 0961203315605365Singla S, Canter D.L, Vece T.J, et al. Diffuse alveolar hemorrhage as a manifestation of childhood - onset systemic lupus erythematosus. Hosp Pediatr. 2016;6(8):496-500. doi: 10.1542/hpeds.2015-0281Kim D, Choi J, Cho S.K, et al. Clinical characteristics and outcomes of diffuse alveolar hemorrhage in patients with systemic lupus erythematosus. Semin Arthritis Rheum. 2017;46(6):782-7. doi: 10.1016/j.semarthrit.2016.09.004Kazzaz N.M, Coit P, Lewis E.E, et al. Systemic lupus erythematosus complicated by diffuse alveolar hemorrhage: Risk factors, therapy and survival. Lupus Sci Med. 2015;2(1):e000117. doi: 10.1136/lupus-2015-000117Mittoo S, Fell C.D. Pulmonary manifestation of systemic lupus erythematosus. Semin Respir Crit Care Med. 2014;35(2):249-54. doi: 10.1055/s-0034-1371537Ednalino C, Yip J, Carsons S.E. Systematic review of diffuse alveolar hemorrhage in systemic lupus erythematosus: Focus on outcome and therapy. J Clin Rheumatol. 2015;21(6):305-10. doi: 10.1097/RHU.0000000000000291Kwok S.K, Moon S.J, Lu J.H, et al. Diffuse alveolar hemorrhage in systemic lupus erythematosus: risk factors and clinical outcome: Results from affiliated hospitals of Catholic University of Korea. Lupus. 2011;20(1):102-7. doi: 10.1177/0961203310381511Picard C, Cadranel J, Porcher R, et al. Alveolar hemorrhage in the immunocompetent host: a scale for early diagnosis of immune cause. Respiration. 2010;80:313-20. doi: 10.1159/000315144Rabe C, Appenrodt B, Hoff C, et al. Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care. J Crit Care. 2010;25(2):230-5. doi: 10.1016/j.jcrc.2009.04.009Jin S.M, Yim J.J, Yoo C.G, et al. Aetiologies and outcomes of diffuse alveolar hemorrhage presenting as acute respiratory failure of uncertain cause. Respirology. 2009;14:290-4. doi: 10.1111/j.1440-1843.2008.01444.xDe Prost N, Parrot A, Picard C, et al. Diffuse alveolar haemorrhage: factors associated with in - hospital and long - term mortality. Eur Respir J. 2010; 35(6):1303-11. doi: 10. 1183/09031936.00075309Schwartz R, Myerson R.M, LawrenceT, et al. Mitral stenosis, massive pulmonary hemorrhage, and emergency valve replacement. N Eng J Med. 1966; 275:755-8. doi: 10.1056/NEJM196610062751404West J.B, Mthieu-Costello O. Volnerability of pulmonary capillaries in heart disease. Circulation. 1995;92:622-31.Spence T.H, Connors J.C. Diffuse alveolar hemorrhage syndrome due to "silent" mitral valve regurgitation. South Med J. 2000;93:65-7.Насонов Е.Л., редактор. Российские клинические рекомендации. Ревматология. М.: ГЭОТАР-Медиа, 2019:464. ISBN: 978-5-9704-4816-8Abal A.T, Nair P.C, Cherian J. Haemoptysis: aetiology, evaluation and outcome - aprospective study in a third - world country. Respir Med. 2001;95(7):548-52. doi: 10.1053/rmed.2001.1053Gillet Y, Issartel B, Vanhems P, et al. Association between Staphylococcus aureus strains carrying gene for Pantone-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet. 2002;359:753-9. doi: 10.1016/S0140-6736(02)07877-7Boussaud V, Parrot A, Mayaud C, et al. Life - threatening hemoptysis in adults with community - acquired pneumonia due to Panton-Valentine leucocidin - secreting Staphylococcus aureus. Intensive Care Med. 2003;29:1840-3. doi: 10.1007/s00134-003-1918-5Johnson V, Stockley J.M, Dockrell D, et al. Fever in returned travellers presenting in the United Kingdom: recommendations for investigation and initial management. J Infect. 2009;59:1-18. doi: 10.1016/j.jinf.2009.05.005Damoiseaux J, et al. EUROPLUS ANCA BIOCHIP mosaic: PR3 and MPO antigen microdots improve the laboratory diagnostics of ANCA-associated vasculitis. J Immunol Methods. 2009;348(1-2):67-73. doi: 10.1016/j.jim.2009.07.0 01Марченков Ю.В., Яковлев В.Н., Коржева И.Ю., Алексеев В.Г., Мороз В.В. Алгоритмы диагностики и лечения легочных кровотечений. Общая реаниматология. 2013;9(2):45. doi.org/10.15360/1813-9779-2013-2-45Johnson J.P, Moore J.Jr, Austin H.R 3rd, et al. Therapy of anti - glomerular basement membrane antibody disease: analysis of prognostic significance of clinical, pathologic and treatment factors. Medicine (Baltimore). 1985;64:219-27.Betensley A.D, Yankaskas J.R. Factor VIIA for alveolar hemorrhage in microscopic polyangiitis. Am J Respir Crit Care Med. 2002;166(9):1291-2. doi: 10.1164/ajrccm.166.9.267dHenke D, Falk R.J, Gabriel D.A. Successful treatment of diffuse alveolar hemorrhage with activated factor VII. Ann Intern Med. 2004;140(6):493-4.Pathak V, Kuhn J, Gabriel D, Barrow J, Jennette J.C, Henke D.C. Use of activated factor VII in patients with diffuse alveolar hemorrhage: A 10 years institutional experience. Lung. 2015;193(3):375-9. doi: 10.1007/s00408-015-9720-zBaker M.C, Diab K.J, Carlos W.J, Mathur P. Intrapulmonary recombinant factor VII as an effective treatment for diffuse alveolar hemorrhage: A case series. J Bronchology Interv Pulmonol. 2016;23(3):255-8. doi: 10.1097/LBR.0000000000 000286Schmidt M, Bailey M, Sheldrake J, Hodgson C, Aubron C, Rycus P.T, Scheinkestel C, Cooper D.J, Brodie D, Pellegrino V, Combes A, Pilcher D. Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score. Am J Respir Crit Care Med. 2014;189:1374-82. doi: 10.1164/rccm.201311-2023OCYusuff H, Malagon I, Robson K, Parmar J, Hamilton P, Falter F. Extracorporeal membrane oxygenation for life - threatening ANCA-positive pulmonary capillaritis. A review of UK experience. Heart Lung Vessel. 2015; 7(2):159-67.Лысенко М.А., Фролова Н.Ф., Кецкало М.В., Дьякова Е.Н., Сысоева И.Л., Жилинская Т.Р., Котенко О.Н., Волгина Г.В. Экстракорпоральная мембранная оксигенация при жизнеугрожающем ANCA-позитивном диффузном некротизирующем геморрагическом альвеолите. Клиническая нефрология. 2018;3:57-62. doi: https://dx.doi. org/10.18565/nephrology.2018.3.57-62Булач Т.П., Ершов А.Л. Подходы к выбору стратегии респираторной поддержки при респираторном дистресс - синдроме взрослых (научный обзор). Профилактическая и клиническая медицина. 2017;4(65):35-40.Левин А.В., Цеймах Е.А., Ананко О.Н. и др. Применение клапанной бронхоблокации у больных с легочным кровотечением при распространенном туберкулезе. Грудная и сердечно - сосудистая хирургия. 2005;(3):39-43 [.Hayakawa K, Tanaka F, Torizuka T, Mitsumori M, Okuno Y, Matsui A, Satoh Y, Fujiwara K, Misaki T. Bronchial artery embolization for hemoptysis: immediate and long - term results. Cardiovasc Intervent Radiol. 1992;15(3):154-8.Tamashiro A, Miceli M.H, Rando C, Tamashiro G.A, Villegas M.O, Dini A.E, Balestrin A.E, Diaz J.A. Pulmonary artery access embolization in patients with massive hemoptysis in whom bronchial and/or non bronchial systemic artery embolization is contraindicated. Cardiovasc Intervent Radiol. 2008;31(3): 633-7. doi: 10.1007/s00270-007-9265-5Ramakantan R, Bandekar V.G, Gandhi M.S, Aulakh B.G, Deshmukh H.L. Massive hemoptysis due to pulmonary tuberculosis: control with bronchial artery embolization. Radiology. 1996;200(3):691-4. doi: 10.1148/radiology.200.3.87569 16Mesurolle B, Lacombe P, Barre O, Qanadli S, Mulot R.O, Chagnon S. [Failures and complications of bronchial artery embolization]. Rev Mal Respir. 1996;13(3):217-25.