<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">33417</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Amiodaron-induced thyroid dysfunction: pathogenesis, diagnosis, treatment</article-title><trans-title-group xml:lang="ru"><trans-title>ИНДУЦИРОВАННАЯ АМИОДАРОНОМ ДИСФУНКЦИЯ ЩИТОВИДНОЙ ЖЕЛЕЗЫ(ПАТОГЕНЕЗ, ДИАГНОСТИКА, ЛЕЧЕНИЕ)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Melnichenko</surname><given-names>G A</given-names></name><name xml:lang="ru"><surname>Мельниченко</surname><given-names>Г А</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эндокринологический научный центр РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sviridenko</surname><given-names>N Yu</given-names></name><name xml:lang="ru"><surname>Свириденко</surname><given-names>Н Ю</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эндокринологический научный центр РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Molaskenko</surname><given-names>N V</given-names></name><name xml:lang="ru"><surname>Молашенко</surname><given-names>Н В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эндокринологический научный центр РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Platonova</surname><given-names>N М</given-names></name><name xml:lang="ru"><surname>Платонова</surname><given-names>Н М</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эндокринологический научный центр РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aleksandrova</surname><given-names>G F</given-names></name><name xml:lang="ru"><surname>Александрова</surname><given-names>Г Ф</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эндокринологический научный центр РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Egorov</surname><given-names>A V</given-names></name><name xml:lang="ru"><surname>Егоров</surname><given-names>А В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эндокринологический научный центр РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Эндокринологический научный центр РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2003-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2003</year></pub-date><volume>78</volume><issue>8</issue><issue-title xml:lang="en">NO8 (2003)</issue-title><issue-title xml:lang="ru">Том 78, №8 (2003)</issue-title><fpage>92</fpage><lpage>96</lpage><history><date date-type="received" iso-8601-date="2020-04-13"><day>13</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2003, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2003, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2003</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/33417">https://ter-arkhiv.ru/0040-3660/article/view/33417</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>review</kwd><kwd>amiodaron</kwd><kwd>iodine</kwd><kwd>thyroid</kwd><kwd>hypothyroidism</kwd><kwd>thyrotoxicosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>амиодарон</kwd><kwd>йод</kwd><kwd>щитовидная железа</kwd><kwd>гипотиреоз</kwd><kwd>тиреотоксикоз</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Connolly S. J. Evidence-based analysis of amiodarone efficacy and safety. Circulation 1999; 100: 2025-2034.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Голицын С. Г. Принципы фармакотерапии желудочковых нарушений ритма сердца. Клин, фармакол. и тер. 1997; 6 (3): 14-16.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Голицын С. П. Грани пользы и риска в лечении желудочковых нарушений ритма сердца. Международ, журн. мед. практики 2000; 10: 56-64.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Singh В. N., Vencatesh N., Kannan R. et al. The historical development, cellular electrophysiology and pharmacology of amiodarone. Progr. Cardiovasc. Dis. 1989; 31 (4): 249-280.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Burkart F., Pfisterer M., Kiowski W. et al. Effect of antiarrhythmic therapy on mortality in survivors of myocardial infarction with asymptomatic complex ventricular arrhythmias: Basel Antiarrhytmic Study on Infarct Survival (BASIS). J. Am. Coll. Cardiol. 1990; 16; 1711-1718.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ceremuzynski L., Kleczar E., Krzeminska-Pacula M. et al. The effect of amiodarone on mortality after myocardial infarction double blind, placebo controlled, pilot study. Ibid. 1992; 20: 1056-1062.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Boutitie F., Boissel J.-P., Connolly S. J. et al. Amiodarone interaction with p-blockers. Analysis of merged EMIAT and CAMIAT databases. Circulation 1999; 99: 2268-2275.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Cairns J. A., Connolly S. J., Roberts R. et al. Randomized trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarization: CAMIAT. Lancet 1997; 349: 675-682.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Braverman Lewis E., Roti E. Disease of the thyroid. Totowa, New Jersy: Humana press; 1997. 401-413.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Wiersinga W. W. Amiodarone and the thyroid. In: Weetman A. P., Grossman A., eds. Pharmacotherapeutics of the thyroid gland. Berlin: Springer-Verlag; 1997. 225-287.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Стокигт Ж. Р. Влияние лекарственных препаратов на функцию щитовидной железы. Thyroid intern. 2000; 2: 4- 13.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Сингер П., Гершман Д. Болезни щитовидной железы. В кн.: Лавин Н. (ред.) Эндокринология. М.: Практика; 1999. 536-550.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Loh К. Amiodarone-induced thyroid disorders: clinical review. Postgrad. Med. J. 2000; 76: 133-140.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Bogazzi F., Bartalena L., Martino E. et al. The various effects of amiodarone on thyroid function. Thyroid 2001; 11 (5): 511-519.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Drexhage H. A., de Wit H. J., Mooij P. Iodine and thyroid autoimmune disease. In: The thyroid and environment: Merck European thyroid symposium. Budapest; 2000. 22-25.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Longer P. Increased iodine intake and autoimmune thyreoiditis: exclamation and question marks, facts and myth. Thyroid Gland 1996; 1: 3-17.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Foresti V., Pepe R., Parisio E. et al. Antithyroid antibodies during amiodarone treatment. Acta Endocrinol. (Kbh.). 1989; 121: 203-206.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Safran M., Martino E., Aghini-Lombardi F. et al. Effect of amiodarone on circulating antithyroid antibodies. Br. Med. J. 1988; 297: 456-457.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Di Matola Т., D'Ascoli F., Fenzi G. et al. Amiodarone induces cytochrome С release and apoptosis through an iodine-independent mechanism. J. Clin. Endocrinol. Metab. 2000; 85 (11): 4323-4330.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Di Matola Т., Vitale M., Fenzi G. et al. Iodine excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress. J. Endocrinol. 2000; 141 (2): 598-605.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Chiovato E., Santiti F., Pinchera А. Лечение гипертиреоза. Тироид Россия 1997; 1: 27-38.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Newman С. М., Price A., Davies D. W. et al. Amiodarone and the thyroid: a practical guide to the management of thyroid dysfunction induced by amiodarone therapy. Heart 1998; 79: 121-127.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Beddows S. A., Page S. R., Taylor A. H. et al. Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes. Biochem. Pharmacol. 1989; 38: 4397-4403.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Cappiello E., Boldorini R., Tosoni A. et al. Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis. J. Endocrinol. Invest. 1995; 18 (11): 862-868.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Bartalena E., Grasso E., Brogioni S. et al. Serum interleukin-6 in amiodarone-induced thyrotoxicosis. J. Clin. Endocrinol. Metab. 1994; 78 (2): 423-427.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Bauters С., d'Herbomes М., Nocaudie M. et al. IL-6 and radioactive iodine uptake in patiens with amiodaron-induced thyrotoxicosis. J. Endocrinol. Invest. 1999; 22 (6, suppl.): 94.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Wolff J. Perchlorate and the thyroid gland. Pharmacol. Rev. 1998; 50: 89-105.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Dikstein G., Shechner C., Adai F. et al. Lithium treatment in amiodarone-induced thyrotoxicosis. Am. J. Med. 1997; 102: 454-458.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Meurisse M., Hamoir E., D'Silva M. et al. Amiodarone - induced thyrotoxicosis: is there a place for surgery? Wld J. Surg. 1993; 17: 622-621.</mixed-citation></ref></ref-list></back></article>
