Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya33382Analysis of the gene polymorphism of matrix metalloproteinase-2 and -9 in patients with coronary heart diseaseShevchenkoAlla Vladimirovnashalla64@mail.ruGolovanovaOl'ga Valer'evnagolovanova_olga@mail.ruKonenkovVladimir Iosifovichkonen@soramn.ruTolkachevaOl'ga Mikhaylovnatolkacheva-olga@mail.ruMaksimovVladimir Nikolaevichmedik11@mail.ruVoevodaMikhail Ivanovichvoevoda@iimed.ruRomashchenkoAida Gerasimovnaromasch@bionet.nsc.ruShevchenkoA VClinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences-GolovanovaO VClinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences-KonenkovV IClinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences-TolkachevaO MTown Clinical Hospital Twenty-Nine-MaksimovV NResearch Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences-VoyevodaM IResearch Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences-RomashchenkoA GInstitute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences-Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical SciencesTown Clinical Hospital Twenty-NineResearch Institute of Therapy, Siberian Branch, Russian Academy of Medical SciencesInstitute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences15012010821313413042020Copyright © 2010, Consilium Medicum2010Aim. To analyze the gene polymorphisms of matrix metalloproteinase-2 and -9 in patients with coronary heart disease (CHD).
Materials and methods. The influence of single nucleotide polymorphism in the promoter region of the gene of matrix metalloproteinase (MMP)-2 at position -1306 and that of MMP-9 at position -1562 on the development of complications was studied in 181 patients with atherosclerosis by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of amplification products.
Results. A significant genotype increase with enhanced MMP-9 gene transcriptional activity was found in the patients aged 55 years inclusively who had been diagnosed as having myocardial infarction as compared with an older age group and, on the contrary, a rise in the MMP-2 genotype with a high promoter activity in the older age group.
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