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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">33021</article-id><article-id pub-id-type="doi">10.26442/00403660.2019.03.000077</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Multidisciplinary approach in the diagnosis of idiopathic nonspecific interstitial pneumonia</article-title><trans-title-group xml:lang="ru"><trans-title>Мультидисциплинарный подход в диагностике идиопатической неспецифической интерстициальной пневмонии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ovcharenko</surname><given-names>S I</given-names></name><name xml:lang="ru"><surname>Овчаренко</surname><given-names>Светлана Ивановна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., проф. каф. факультетской терапии №1 лечебного фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский Университет); ORCID: 0000-0002-8264-6635</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Son</surname><given-names>E A</given-names></name><name xml:lang="ru"><surname>Сон</surname><given-names>Елена Алексеевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент каф. факультетской терапии №1 лечебного фак-та; ORCID: 0000-0002-5168-8752</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kapustina</surname><given-names>V A</given-names></name><name xml:lang="ru"><surname>Капустина</surname><given-names>Валентина Андреевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ассистент каф. факультетской терапии №1 лечебного фак-та; ORCID: 0000-0001-6512-1629</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2019</year></pub-date><volume>91</volume><issue>3</issue><issue-title xml:lang="en">VOL 91, NO3 (2019)</issue-title><issue-title xml:lang="ru">ТОМ 91, №3 (2019)</issue-title><fpage>101</fpage><lpage>106</lpage><history><date date-type="received" iso-8601-date="2020-04-11"><day>11</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/33021">https://ter-arkhiv.ru/0040-3660/article/view/33021</self-uri><abstract xml:lang="en"><p>The article provides a modern classification of interstitial lung diseases. The focus is on the poorly studied and difficult to diagnose idiopathic nonspecific interstitial pneumonia, isolated in a separate nosological form and included in the classification only in 2002. The paper presents the features of the clinical, radiological, histological picture of idiopathic nonspecific interstitial pneumonia in comparison with idiopathic pulmonary fibrosis. The presented materials are based on the results of the largest study conducted by the working group of the American Thoracic Society, which shows the importance of the interaction of specialists in the diagnosis of idiopathic nonspecific interstitial pneumonia. A comprehensive assessment of the examination of patients conducted in collaboration with the clinician and radiologist, after their cooperative discussion, in many cases can help to avoid lung biopsy, and the study of morphological material is more often necessary only in difficult diagnostic situations.</p></abstract><trans-abstract xml:lang="ru"><p>В статье дается современная классификация интерстициальных заболеваний легких. Основное внимание уделяется малоизученной и трудно диагностируемой идиопатической неспецифической интерстициальной пневмонии, выделенной в отдельную нозологическую форму и включенной в классификацию лишь в 2002 г. В работе представлены особенности клинической, рентгенологической, гистологической картины идиопатической неспецифической интерстициальной пневмонии в сравнении с идиопатическим легочным фиброзом. Представленные материалы базируются на результатах самого крупного исследования, проведенного рабочей группой Американского торакального общества, в котором показана важность взаимодействия специалистов в диагностике идиопатической неспецифической интерстициальной пневмонии. Комплексная оценка обследования пациентов, проводимого в содружестве клинициста и рентгенолога, после их совместного обсуждения во многих случаях может помочь избежать проведения биопсии легких, а исследование морфологического материала чаще бывает необходимо лишь в сложных для диагностики ситуациях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>interstitial lung diseases</kwd><kwd>idiopathic interstitial pneumonia</kwd><kwd>idiopathic nonspecific interstitial pneumonia</kwd><kwd>idiopathic pulmonary fibrosis</kwd><kwd>multidisciplinary approach</kwd><kwd>high resolution computed tomography</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>интерстициальные заболевания легких</kwd><kwd>идиопатическая интерстициальная пневмония</kwd><kwd>идиопатическая неспецифическая интерстициальная пневмония</kwd><kwd>идиопатический легочный фиброз</kwd><kwd>мультидисциплинарный подход</kwd><kwd>компьютерная томография высокого разрешения</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Amer J Respiratory and Critical Care Medicine. 2002;165:277-304. https://doi.org/10.1164/ajrccm.165.2.ats01</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Travis W.D, et al. Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project. Amer J Respiratory and Critical Care Medicine. 2008;177:1338-47. https://doi.org/10.1164/rccm.2006 11-1685OC</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Nicholson A.G, Colby T.V, Wells A.U. Histopathological approach to patterns of interstitial pneumonia in patient with connective tissue disorders. Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2002;19:10-7.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Fujita J, Yoshinouchi T, Ohtsuki Y, Tokuda M, Yang Y, Yamadori I, Bandoh S, Ishida T, Takaharaa J, Ueda R. Non - specific interstitial pneumonia as pulmonary involvement of systemic sclerosis. Annals of the Rheumatic Diseases. 2001;60:281-3. https://doi.org/10.1136/ard.60.3.281</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Desai S.R, Veeraraghavan S, Hansell D.M, Nikolakopolou A, Goh N.S.L, Nicholson A.G, Colby T.V, Denton C.P, Black C.M, du Bois R.M, Wells A.U. CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. Radiology. 2004;232:560-7. https://doi.org/10.1148/radiol.2322031223</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Bouros D, Wells A.U, Nicholson A.G, Colby T.V, Polychronopoulos V, Pantelidis P, Haslam P.L, Vassilakis D.A, Black C.M, du Bois R.M. Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Amer J Respiratory and Critical Care Medicine. 2002;165:1581-6. https://doi.org/10.1164/rccm.2106012</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Tansey D, Wells A.U, Colby T.V, Ip S, Nikolakoupolou A, du Bois R.M, Hansell D.M, Nicholson A.G. Variations in histological patterns of interstitial pneumonia between connective tissue disorders and their relationship to prognosis. Histopathology. 2004;44:585-96. https://doi.org/10.1111/j.1365-255 9.2004.01896.x</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kim D.S, Yoo B, Lee J.S, Kim E.K, Lim C.M, Lee S.D, Koh Y, Kim W.S, Kim W.D, Colby T.V, Kitiaichi M. The major histopathologic pattern of pulmonary fibrosis in scleroderma in nonspecific interstitial pneumonia. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 2002;19:121-7.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Flieder D.B, Travis W.D. Pathologic characteristics of drug - induced lung disease. Clinics in Chest Medicine. 2004;25:37-45. https://doi.org/10.1016/ s0272-5231(03)00138-2</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Rossi S.E, Erasmus J.J, Mc Adams H.P, Sporn T.A, Goodman P.C. Pulmonary drug toxicity: radiologic and pathologic manifestations. Radiographics. 2000;20:1245-59. https://doi.org/10.1148/radiographics.20.5.g0 0se081245</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Pesenti S, Lauque D, Daste G, Boulay V, Pujazon M-C, Carles P. Diffuse infiltrative lung disease associated with flecainide: report of two cases. Respiration. 2002;69:182-5. https://doi.org/10.1159/000056325</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Nishiyama O, Kondoh Y, Taniguchi H, Yamaki K, Suzuki R, Yokoi T, Takagi K. Serial high resolution CT findings in nonspecific interstitial pneumonia/fibrosis. J Computer Assisted Tomography. 2000;24:41-6. https:// doi.org/10.1097/00004728-200001000-00008</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Schwaiblmair M, Behr W, Haeckel T, Märk B, Foerg W, Berghaus T. Drug induced interstitial lung disease. The Open Respiratory Medicine J. 2012;6:63-74. https://doi.org/10.2174/1874306401206010063</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Amer J Respiratory and Critical Care Medicine. 2013;188(6):733-48. https://doi.org/10.1164/rccm.201308-148 3ST</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>An Official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence - based guidelines for diagnosis and management. Amer J Respiratory and Critical Care Medicine. 2011;183:788-824. https://doi.org/10.1164/rccm.201308-1483ST</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>ATS/ERS/JRS/ALAT Clinical Practice Guideline: treatment of idiopathic pulmonary fibrosis. Amer J Respiratory and Critical Care Medicine. 2015;192(2):e3-e19. https://doi.org/10.1164/rccm.201506-1063ST</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Matsushima H, Takayanagi N, Sakamoto T, et al. Pathologic findings both before and after steroid therapy in a case of desquamative interstitial pneumonia [article in Japanese]. Nihon Kokyuki Gakkai Zasshi. 2001;39:609-14.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Ryerson C.J, Urbania T.H, Richeldi L, Mooney J.J, Lee J.S, Jones K.D, Elicker B.M, Koth L.L, King T.E.Jr, Wolters P.J, Collard H.R. Prevalence and prognosis of unclassifiable interstitial lung disease. European Respiratory J. 2013;42(3):750-7. https://doi.org/10.1183/09031936.00131912</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Johkoh T, Müller N.L, Colby T.V, Ichikado K, Taniguchi H, Kondoh Y, Fujimoto K, Kinoshita M, Arakawa H, Yamada H, Suga M, Ando M, Koyama M, Nakamura H. Nonspecific interstitial pneumonia: correlation between thin - section CT findings and pathologic subgroups in 55 patients. Radiology. 2002;225:199-204. https://doi.org/10.1148/radiol.2251011555</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Park J.S, Lee K.S, Kim J.S, Park C.S, Suh Y.L, Choi D.L, Kim K.J. Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients. Radiology. 1995;195:645-8. https://doi.org/10.1148/ radiology.195.3.7753988</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Katzenstein A.L, Fiorelli R.F. Nonspecific interstitial pneumonia/fibrosis: histologic features and significance. Am J Surg Pathol. 1994;18:136-47. https://doi.org/10.1097/00000478-199402000-00003</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Do K.H, Lee J.S, Colby T.V, Kitaichi M, Kim D.S. Nonspecific interstitial pneumonia versus usual interstitial pneumonia: differences in the density histogram of high - resolution CT. J Computer Assisted Tomography. 2005;29:544-8. https://doi.org/10.1097/01.rct.0000164255.43859.96</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Jegal Y, Kim D.S, Shim T.S, Lim C-M, Lee S.D, Koh Y, Kim W.S, Kim W.D, Lee J.S, Travis W.D, Kitaichi M, Colby T.V. Physiology is a stronger predictor of survival than pathology in fibrotic interstitial pneumonia. Amer J Respiratory and Critical Care Medicine. 2005;171:639-44. http://doi.org/10.1164/rccm.200403-331oc</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Nagai S, Kitaichi M, Itoh H, Nishimura K, Izumi T, Colby T.V. Idiopathic nonspecific interstitial pneumonia/fibrosis: comparison with idiopathic pulmonary fibrosis and BOOP. European Respiratory J. 1998;12:1010-9. https://doi.org/10.1183/09031936.98.12051010</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Daniil Z.D, Gilchrist F.C, Nicholson A.G, Hansell D.M, Harris J, Colby T.V, du Bois R.M. histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. Amer J Respiratory and Critical Care Medicine. 1999;160:899-905. https://doi.org/10.1164/ajrccm.16 0.3.9903021</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Cottin V, Donsbeck A-V, Revel D, Loire R, Cordier J-F. Nonspecific interstitial pneumonia. Individualization of a clinicopathologic entity in a series of 12 patients. Amer J Respiratory and Critical Care Medicine. 1998;158:1286-93. https://doi.org/10.1164/ajrccm.158.4.9802119</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Travis W.D, Matsui K, Moss J, Ferrans V.J. Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia. Amer J Surgical Pathology. 2000;24:19-33.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Bjoraker J.A, Ryu J.H, Edwin M.K, Myers J.L, Tazelaar H.D, Schroeder D.R, Offord K.P. Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Amer J Respiratory and Critical Care Medicine. 1998;157:199-203. https://doi.org/10.1164/ajrccm.157.1.9704130</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Padley S.P, Adler B, Müller N.L. High - resolution computed tomography of the chest: current indications. J Thoracic Imaging. 1993;8:189-99. https://doi.org/10.1007/978-3-642-79887-0_11</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Lynch D.A, Rose C.S, Way D, King T.E. Hypersensitivity pneumonitis: sensitivity of high - resolution CT in a population - based study. Amer J Roentgenology. 1992;159:469-72. https://doi.org/10.2214/ajr.159.3.1503007</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Orens J.B, Kazerooni E.A, Martinez F.J, Curtis J.L, Gross B.H, Flint A, Lynch J.P. The sensitivity of high - resolution CT in detecting idiopathic pulmonary fibrosis proved by open lung biopsy. A prospective study. Chest. 1995;108:109-15. https://doi.org/10.1378/chest.108.1.109</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Чучалин А.Г., Авдеев С.Н., Айсанов З.Р., Белевский А.С., Демура С.А., Илькович М.М., Коган Е.А., Самсонова М.В., Сперанская А.А., Тюрин И.Е., Черняев А.Л., Черняк Б.А., Черняк А.В., Шмелев Е.И. Диагностика и лечение идиопатического легочного фиброза. Федеральные клинические рекомендации. Пульмонология. 2016;26(4):399-419. http://dx.doi.org/10.18093/0869-0189-2016-26-4-399-419.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Hansell D.M, Bankier A.A, Mac Mahon H, Mc Loud T.C, Müller N.L, Remy J. Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246;697-722. https://doi.org/10.1148/radiol.2462070712</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Grenier P, Chevret S, Beigelman C, Brauner M.W, Chastang C, Valeyre D. Chronic diffuse infiltrative lung disease: determination of the diagnostic value of clinical data, chest radiography, and CT and Bayesian analysis. Radiology. 1994;191:383-90. https://doi.org/10.1148/radiology.191.2.8153310</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Hartman T.E, Swensen S.J, Hansell D.M, Colby T.V, Myers J.L, Tazelaar H.D, Nicholson A.G, Wells A.U, Ryu J.H, Midthun D.E, du Bois R.M, Müller N.L. Nonspecific interstitial pneumonia: variable appearance at high - resolution chest CT. Radiology. 2000;217:701-5. https://doi.org/10.1148/radiology.217.3.r00 nv31701</mixed-citation></ref></ref-list></back></article>
