Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3297510.26442/00403660.2019.02.000042Editorial articleПередовая статьяReview ArticleGene therapy of type 2 diabetes mellitus: state of artГенная терапия сахарного диабета 2-го типа: состояние и перспективыStafeevYu SСтафеевЮрий Сергеевич

м.н.с. лаб. ангиогенеза НИИЭК ФГБУ НМИЦ кардиологии, аспирант кафедры биохимии и молекулярной медицины факультета фундаментальной медицины ФГБОУ ВО «МГУ им. М.В. Ломоносова»

yuristafeev@gmail.comMenshikovM YuМеньшиковМихаил Юрьевич

д.б.н., в.н.с. лаб. ангиогенеза НИИЭК ФГБУ «НМИЦ кардиологии»

ParfyonovaYe VПарфеноваЕлена Викторовна

д.м.н., зав. лаб. ангиогенеза и директор НИИЭК «ФГБУ НМИЦ кардиологии», зав. лаб. постгеномных технологий в медицине факультета фундаментальной медицины ФГБОУ ВО «МГУ им. М.В. Ломоносова»

National Medical Research Centre for Cardiology of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РоссииM.V. Lomonosov Moscow State UniversityФГБУ ВО «Московский государственный университет им. М.В. Ломоносова»15022019912VOL 91, NO2 (2019)ТОМ 91, №2 (2019)14915211042020Copyright ©; 2019, Consilium MedicumCopyright ©; 2019, ООО "Консилиум Медикум"2019Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32975

Type 2 diabetes mellitus (T2DM) and other metabolic diseases are essential links in the structure of morbidity and mortality in the modern world. The accepted strategy for the correction of T2DM and insulin resistance is drug therapy aimed at delivering insulin from the outside, stimulating the secretion of own insulin and reducing the concentration of blood glucose. However, modern studies demonstrate a great potential for the use of gene therapy approaches for the correction of T2DM and insulin resistance. In the present review, the main variants of plasmid gene therapy of T2DM using the genes of adiponectin and type 1 glucagon-like peptide, as well as the main variants of viral gene therapy of T2DM using the genes of type 1 and leptin are considered. T2DM gene therapy is currently not ready to enter into routine clinical practice, but, subject to improvements in delivery systems, it can be a powerful link in combination therapy for diabetes.

Сахарный диабет 2-го типа (СД2Т) и другие метаболические заболевания представляют собой существенное звено в структуре заболеваемости и смертности в современном мире. Принятой стратегией коррекции СД2Т и инсулинорезистентности является медикаментозная терапия, направленная на доставку инсулина извне, на стимуляцию секреции собственного инсулина и снижение концентрации глюкозы крови. Однако современные исследования демонстрируют большой потенциал применения генно-терапевтических подходов для коррекции СД2Т и инсулинорезистентности. В представленном обзоре рассмотрены основные варианты плазмидной генной терапии СД2Т с использованием генов адипонектина и глюкагон-подобного пептида 1-го типа, а также основные варианты вирусной генной терапии СД2Т с использованием генов глюкагон-подобного пептида 1-го типа и лептина. Генная терапия СД2Т к настоящему времени не готова войти в рутинную клиническую практику, но, при условии совершенствования средств доставки, может стать мощным звеном комбинированной терапии СД2Т.

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