Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya3295010.26442/00403660.2019.02.000152Research ArticleCeliac disease associated with ulcerative colitisKrumsL M-BabaianA F-BykovaS V-LishchinskaiaA A-KhomerikiS G-GudkovaR B-Sabel'nikovaE A-KniazevO V-ParfenovA Iasfold@mail.ruA.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of Moscow15022019912879011042020Copyright © 2019, Consilium Medicum2019The article provides clinical observation of a patient who was diagnosed with celiac disease when he was 52 years (Marsh stage IIIB). Following gluten-free diet (GFD) clinical remission and restoration of small intestinal mucosa (SIM) structure occurred, however in 6 years ulcerative colitis developed and an impairment of SIM morphological structure was identified (Marsh stage IIIA). Ulcerative colitis and celiac disease remission is supported by GFD, anti-cytokine therapy (adalimumab) in combination with mesalazine.celiac diseaseulcerative colitisgluten-free dietanti-cytokine therapyцелиакияязвенный колитаглютеновая диетаантицитокиновая терапия[Paskual V, Dieli-Crimi R, Lopez-Palacios N, Bodas A, Medrano L, Nunez C. Inflammatory bowel disease and celiac disease: Overlaps and differences. World J Gastroennterol. 2014;20(17):4846-56. doi: 10.3748/wig.20i17.4846][Kocsis D, Toth Z, Csontos A.A, Miheller P, Pak P, Herszenyi L, Toth M, Tulassay Z, Juhasz M. Prevalence of inflammatory bowel disease among celiac disease patients in a Hungarian celiac centre. BMC Gastroenterol. 2015;15:141. doi: 101186\s12876-015-0370-7][Jandaghi E, Hojatnia M, Vahedi H, Shahbaz-Khani B. Is the Prevalence of celiac disease Higher than general population in inflammatory bowel disease? Middle East J Dig Dis. 2015;7(2):82-7. PMCID: PMC4430796.][Casella G, Di Bella C, Salemme M, Villanacci V, Antonelli E, Baldini V, Bassotti G. Celiac disease. Non - celiac gluten sensitivity and inflammatory bowel disease. Minevra Gastroenterol Dietol. 2015;61(4):267-71.][Быкова С.В., Сабельникова Е.А., Гудкова Р.Б., Дроздов В.Н., Щербаков П.Л., Кирова М.В., Хомерики С.Г., Варванина Г.Г., Беляева А.А., Парфенов А.И. Частота выявления целиакии у больных гастроэнтерологического профиля. Терапевтический архив. 2016;88(2):39-43. doi: 101716/terarkh201688239-43][Casella G, D’Inca R, Oliva L, Daperno M, Salalino V, Zoli G, Vatall A. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicenter stude. Dig Liver Dis. 2010;42(3):175-8. doi: 10.1016/j.2009.08.005][Cytng S.X, Raizner A, Phatak U.P, Cho J.Y, Panshankar D.S. Celiac disease in child with ulcerative colitis. A possible genetic association. J Clin Gastroenntrol. 2013;47(2):127-9. doi: 10.1097/МСG/0b013e318250e468][Eogamrani Y, Errami A.A, Krati K. A rare association: celiac disease and ulcerative colitis. J Med Diagn Meth. 2016;5:223. doi: 10.4172/2168-9784.1000223][Krawiec P, Pawlowska-Kamienak F, Pac-Kozuchpwska E, Mroczkowska-Juchkiwcz A, Kominek K. Coexistencen of celiac disease and inflammatory bowel disease in children. Pol Merkur Lekarski. 2016;40(235):53-5.]