Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3294810.26442/00403660.2018.12.000014Editorial articleПередовая статьяResearch ArticleNotch signal pathway - therapeutic target for regulation of reparative processes in the heartСигнальный путь Notch - терапевтическая мишень для регуляции репаративных процессов в сердцеDergilevK VДергилевКонстантин Владимирович

к.м.н., в.н.с. лаб. ангиогенеза НМИЦ кардиологии

doctorkote@gmail.comZubkovaE SЗубковаЕкатерина Сергеевна

н.с. лаб. ангиогенеза НМИЦ кардиологии

BeloglazovaI BБелоглазоваИрина Борисовна

к.б.н., с.н.с. лаб. ангиогенеза НМИЦ кардиологии

MenshikovM YuМеньшиковМихаил Юрьевич

к.б.н., в.н.с. лаб. ангиогенеза НМИЦ кардиологии

ParfyonovaE VПарфеноваЕлена Викторовна

д.м.н., проф., директор Института экспериментальной кардиологии НМИЦ кардиологии, руководитель лаб. постгеномных технологий в медицине фак-та фундаментальной медицины МГУ им. М.В. Ломоносова

National Medical Research Center for Cardiology of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РоссииM.V. Lomonosov Moscow State UniversitФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»151220189012VOL 90, NO12 (2018)ТОМ 90, №12 (2018)11212111042020Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32948

Notch signaling pathway is a universal regulator of cell fate in embryogenesis and in maintaining the cell homeostasis of adult tissue. Through local cell-cell interactions, he controls neighboring cells behavior and determines their capacity for self-renewal, growth, survival, differentiation, and apoptosis. Recent studies have shown that the control of regenerative processes in the heart is also carried out with the participation of Notch system. At the heart of Notch regulates migration bone marrow progenitors and stimulates the proliferation of cardiomyocytes, cardiac progenitor cell activity, limits cardiomyocyte hypertrophy and fibrosis progression and stimulates angiogenesis. Notch signaling pathway may be regarded as a very promising target for the development of drugs for the stimulation of regeneration in the myocardium.

Сигнальный путь Notch является универсальным регулятором клеточного гомеостаза в эмбриогенезе и поддержании целостности тканей взрослого организма. Через межклеточные взаимодействия он осуществляет контроль направления развития соседних клеток, а также определяет их способности к самообновлению, росту, выживанию, дифференцировке и апоптозу. Недавние исследования показали, что контроль регенеративных процессов в сердце также осуществляется при участии системы Notch. В сердце Notch регулирует миграцию клеток - предшественников костного мозга, стимулирует пролиферацию кардиомиоцитов, активность прогениторных клеток сердца, ограничивает степень гипертрофии кардиомиоцитов и прогрессирование фиброза, а также стимулирует неоваскулогенез. Сигнальный путь Notch можно рассматривать как весьма перспективную мишень для разработки лекарственных средств направленного действия, используемых с целью стимуляции регенеративных процессов в миокарде.

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