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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">32848</article-id><article-id pub-id-type="doi">10.26442/terarkh2018902105-111</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Optimizing therapy of liver diseases not associated with viral infection</article-title><trans-title-group xml:lang="ru"><trans-title>Оптимизация терапии заболеваний печени, не ассоциированных с вирусной инфекцией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Svistunov</surname><given-names>A A</given-names></name><name xml:lang="ru"><surname>Свистунов</surname><given-names>Андрей Алексеевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>член-корр. РАН, д.м.н., проф., первый проректор Первого МГМУ им. И.М. Сеченова. https://orcid.org/ 0000-0003-1592-5703</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Osadchuk</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Осадчук</surname><given-names>Михаил Алексеевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. каф. поликлинической терапии лечебного факультета Первого МГМУ им. И.М. Сеченова. http://orcid.org/0000=0003=0485=6802</p></bio><email>osadchuk.mikhail@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kireeva</surname><given-names>N V</given-names></name><name xml:lang="ru"><surname>Киреева</surname><given-names>Наталья Викторовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доц. каф. поликлинической терапии лечебного факультета Первого МГМУ им. И.М. Сеченова. https://orcid.org/0000-0002-3467-886X</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Osadchuk</surname><given-names>M M</given-names></name><name xml:lang="ru"><surname>Осадчук</surname><given-names>Максим Михайлович</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., зав. отд. организационно-методической и клинико-экспертной работы Городской поликлиники №52</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenovskiy University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">City Polyclinic No. 52, Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">ГБУЗ г. Москвы «Городская поликлиника №52» ДЗ г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2018</year></pub-date><volume>90</volume><issue>2</issue><issue-title xml:lang="en">VOL 90, NO2 (2018)</issue-title><issue-title xml:lang="ru">ТОМ 90, №2 (2018)</issue-title><fpage>94</fpage><lpage>99</lpage><history><date date-type="received" iso-8601-date="2020-04-11"><day>11</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/32848">https://ter-arkhiv.ru/0040-3660/article/view/32848</self-uri><abstract xml:lang="en"><p>The review demonstrated results and prospects of non-pharmacological and drug therapy patients with liver disease, not associated with a viral infection. The presented data emphasize the relevance of studying the problem of effective therapy of diseases of the liver and its role in improving the course and outcomes of liver disease.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре продемонстрированы итоги и перспективы нелекарственной и лекарственной терапии больных с заболеваниями печени, не ассоциированными с вирусной инфекцией. Представленные данные подчеркивают актуальность изучения проблемы эффективной терапии заболеваний печени и ее роль в улучшении течения и исходов патологии печени.</p></trans-abstract><kwd-group xml:lang="en"><kwd>non-alcoholic and alcoholic fatty liver disease</kwd><kwd>non-pharmacological and pharmacological therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>неалкогольная и алкогольная жировая болезнь печени</kwd><kwd>немедикаментозная и медикаментозная терапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Mokdad A.H, Marks J.S, Stroup D.F, Gerberding J.L. Actual causes of death in the United States, 2000. JAMA. 2004;291(10):1238-45. doi: 10.1001/jama.291.10.1238</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol - use disorders. Lancet. 2009;373(9682):2223-33. doi: 10.1016/s0140-6736(09)60746-7</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>World Health Organization. Global status report on alcohol and health 2014 [Available from: http://www.who.int/substance_abuse/publications/global_alcohol_report/en/].</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Poynard T, Mathurin P, Lai C, Guyader D, Poupon R, Tainturier M.H, Myers R, Muntenau M, Ratziu V, Manns M, et al. A comparison of fibrosis progression in chronic liver diseases. J Hepatol. 2003;38:257-65. doi: 10.1016/s0168-8278(02)00413-0</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Younossi Z.M, Koenig A.B, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease - Meta - analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73-84. doi: 10.1002/hep.28431</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ballestri S, Zona S, Targher G, Romagnoli D, Baldelli E, Nascimbeni F, Roverato A, Guaraldi G, Lonardo A. Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta - analysis. J Gastroenterol Hepatol. 2016;31:936-44. doi: 10.1111/ jgh.13264</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Lonardo A, Ballestri S, Guaraldi G, Nascimbeni F, Romagnoli D, Zona S, Targher G. Fatty liver is associated with an increased risk of diabetes and cardiovascular disease - Evidence from three different disease models: NAFLD, HCV and HIV. World J Gastroenterol. 2016;22:9674-93. doi: 10.3748/wjg.v22.i44.9674</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Rowell R, Anstee Q. An overview of the genetics, mechanisms and management of NAFLD and ALD. Clin Med. 2015;15 Suppl 6:s77-s82. doi: 10.7861/clinmedicine.15-6-s77</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Charlton M.R, Burns J.M, Pedersen R.A, Watt K.D, Heimbach J.K, Dierkhising R.A. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 2011;141(4):1249-53. doi: 10.1053/j.gastro.2011.06.061</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Day C, Anstee Q. The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2. Semin Liver Dis. 2015;35:270-90. doi: 10.1055/s-0035-1562947</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Chamorro A, Torres J, Mirón-Canelo J, González-Sarmiento R, Laso F, Marcos M. Systematic review with meta - analysis: the I148M variant of patatin - like phospholipase domain - containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis. Alimentary Pharmacol Therapeut. 2014;40:571-81. doi: 10.1111/apt.12890</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Sookoian S, Pirola C.J. Meta - analysis of the influence of I148M variant of patatin - like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology. 2011;53(6):1883-94. doi: 10.1002/hep.24283</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Trépo E, Nahon P, Bontempi G, Valenti L, Falleti E, Nischalke H, Hamza S, Corradini S, Burza M, Guyot E, et al. Association between the PNPLA3 (rs738409 C&gt;G) variant and hepatocellular carcinoma: Evidence from a meta - analysis of individual participant data. Hepatology. 2014;59(6):2170-7. doi: 10.1002/hep.26767</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Issa D, Wattacheril J, Sanyal A.J. Treatment options for nonalcoholic steatohepatitis - a safety evaluation. Expert Opin Drug Safety. 2017 Aug;16(8):903-13. doi: 10.1080/14740338.2017.1343299</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Mathurin P, O’Grady J, Carithers R, Phillips M, Louvet A, Mendenhall C, Ramond M, Naveau S, Maddrey W, Morgan T. Corticosteroids improve short - term survival in patients with severe alcoholic hepatitis: meta - analysis of individual patient data. Gut. 2010;60(2):255-60. doi: 10.1136/gut.2010.224097</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Fialla A, Israelsen M, Hamberg O, Krag A, Gluud L. Nutritional therapy in cirrhosis or alcoholic hepatitis: a systematic review and meta - analysis. Liver Intern. 2015;35(9):2072-8. doi: 10.1111/liv.12798</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Naveau S, Giraud V, Borotto E, Aubert A, Capron F, Chaput J. Excess weight risk factor for alcoholic liver disease. Hepatology. 1997;25(1): 108-11. doi: 10.1002/hep.510250120</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Hutchinson S, Bird S, Goldberg D. Influence of alcohol on the progression of hepatitis C virus infection: A meta - analysis. Clin Gastroenterol Hepatol. 2005;3(11):1150-9. doi: 10.1016/s1542-3565(05)00407-6</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Chen C, Yoon Y, Yi H, Lucas D. Alcohol and hepatitis C mortality among males and females in the United States: a life table analysis. Alcoholism: Clin Exper Res. 2007;31(2):285-92. doi: 10.1111/j.1530-0277.2006.00304.x</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Harris D, Gonin R, Alter H, Wright E, Buskell Z, Hollinger F, Seeff L. The Relationship of Acute Transfusion-Associated Hepatitis to the Development of Cirrhosis in the Presence of Alcohol Abuse. Ann Intern Med. 2001;134(2):120-4. doi: 10.7326/0003-4819-134-2-200101160-00012</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Tsui J, Pletcher M, Vittinghoff E, Seal K, Gonzales R. Hepatitis C and hospital outcomes in patients admitted with alcohol - related problems. J Hepatol. 2006;44(2):262-6. doi: 10.1016/j.jhep.2005.07.027</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Lucey M, Mathurin P, Morgan T. Alcoholic hepatitis. New Engl J Med. 2009;360(26):2758-69. doi: 10.1056/nejmra0805786</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Mathurin P, Mendenhall C.L, Carithers R.L. Jr, Ramond M.J, Maddrey W.C, Garstide P, Rueff B, Naveau S, Chaput J.C, Poynard T. Corticosteroids improve short - term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J Hepatol. 2002;36(4):480-7. doi: 10.1016/s0168-8278(01)00289-6</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Raetsch C, Jia J, Boigk G, Bauer M, Hahn E, Riecken E, Schuppan D. Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis. Gut. 2002;50(2):241-7. doi: 10.1136/gut.50.2.241</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Assimakopoulos S, Thomopoulos K, Labropoulou-Karatza C. Pentoxifylline: A first line treatment option for severe alcoholic hepatitis and hepatorenal syndrome? World J Gastroenterol. 2009;15(25):3194-5. doi: 10.3748/wjg.15.3194</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Mc Clain C, Hill D, Barve S. Infliximab and prednisolone: Too much of a good thing? Hepatology. 2004;39(6):1488-90. doi: 10.1002/ hep.20267</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Felver M, Mezey E, Mc Guire M, Mitchell M, Herlong H, Veech G, Veech R. Plasma Tumor Necrosis Factor alpha Predicts Decreased Long-Term Survival in Severe Alcoholic Hepatitis. Alcoholism: Clin Exper Res. 1990;14(2):255-9. doi: 10.1111/j.1530-0277.1990.tb00482.x</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Yin M, Wheeler M, Kono H, Bradford B, Gallucci R, Luster M, Thurman R. Essential role of tumor necrosis factor alpha in alcohol - induced liver injury in mice. Gastroenterology. 1999;117(4):942-52. doi: 10.1016/s0016-5085(99)70354-9</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Naveau S, Chollet-Martin S, Dharancy S, Mathurin P, Jouet P, Piquet M, Davion T, Oberti F, Broët P, Emilie D. A double - blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology. 2004;39(5):1390-7. doi: 10.1002/hep.20206</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Stadlbauer V, Mookerjee R, Hodges S, Wright G, Davies N, Jalan R. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J Hepatol. 2008;48(6):945-51. doi: 10.1016/j.jhep.2008.02.015</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Kirpich I, Solovieva N, Leikhter S, Shidakova N, Lebedeva O, Sidorov P, Bazhukova T, Soloviev A, Barve S, Mc Clain C, Cave M. Probiotics restore bowel flora and improve liver enzymes in human alcohol - induced liver injury: a pilot study. Alcohol. 2008;42(8):675-82. doi: 10.1016/j.alcohol.2008.08.006</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Vlachogiannakos J, Saveriadis A, Viazis N, Theodoropoulos I, Foudoulis K, Manolakopoulos S, Raptis S, Karamanolis D. Intestinal decontamination improves liver haemodynamics in patients with alcohol - related decompensated cirrhosis. Aliment Pharmacol Ther. 2009;29(9):992-9. doi: 10.1111/j.1365-2036.2009.03958.x</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Michelena J, Altamirano J, Abraldes J, Affò S, Morales-Ibanez O, Sancho-Bru P, Dominguez M, García-Pagán J, Fernández J, Arroyo V, et al. Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis. Hepatology. 2015;62(3):762-72. doi: 10.1002/hep.27779</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Zhang Z, Wang F. Stem cell therapies for liver failure and cirrhosis. J Hepatol. 2013;59(1):183-5. doi: 10.1016/j.jhep.2013.01.018</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Akiyama K, Chen C, Wang D, Xu X, Qu C, Yamaza T, Cai T, Chen W, Sun L, Shi S. Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis. Cell Stem Cell. 2012;10(5):544-55. doi: 10.1016/j.stem.2012.03.007</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Aurich H, Sgodda M, Kaltwasser P, Vetter M, Weise A, Liehr T, Brulport M, Hengstler J, Dollinger M, Fleig W, Christ B. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut. 2009;58(4):570-81. doi: 10.1136/gut.2008.154880</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Kuo T, Hung S, Chuang C, Chen C, Shih Y, Fang S, Yang V, Lee O. Stem Cell Therapy for Liver Disease: Parameters Governing the Success of Using Bone Marrow Mesenchymal Stem Cells. Gastroenterology. 2008;134(7):2111-21.e3. doi: 10.1053/j.gastro.2008.03.015</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Jang Y, Kim Y, Baik S, Kim M, Eom Y, Cho M, Park H, Park S, Kim B, Kim J, et al. Histological improvement following administration of autologous bone marrow - derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study. Liver International. 2014;34(1):33-41. doi: 10.1111/liv.12218</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y, Uchida K, Yamasaki T, Fujii Y, et al. Improved Liver Function in Patients with Liver Cirrhosis After Autologous Bone Marrow Cell Infusion Therapy. Stem Cells. 2006;24(10):2292-8. doi: 10.1634/stemcells.2005-0542</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Ismail A, Fouad O, Abdelnasser A, Chowdhury A, Selim A. Stem Cell Therapy Improves the Outcome of Liver Resection in Cirrhotics. J Gastrointestin Cancer. 2010;41(1):17-23. doi: 10.1007/s12029-009-9092-9</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Singh S, Osna N, Kharbanda K. Treatment options for alcoholic and non - alcoholic fatty liver disease: A review. World J Gastroenterol. 2017;23(36):6549-70. doi: 10.3748/wjg.v23.i36.6549</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>EASL-EASD-EASO Clinical Practice Guidelines for the management of non - alcoholic fatty liver disease. Diabetologia. 2016 Jun; 59(6):1121-40. doi: 10.1007/s00125-016-3902-y</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Ивашкин В.Т., Маевская М.В., Павлов Ч.С., Тихонов И.Н., Широкова Е.Н., Буеверов А.О., Драпкина О.М., Шульпекова Ю.О., Цуканов В.В., Маммаев С.Н., Маев И.В., Пальгова Л.К. Клинические рекомендации по диагностике и лечению неалкогольной жировой болезни печени Российского общества по изучению печени и Российской гастроэнтерологической ассоциации. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2016;26(2): 24-42.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Takahashi Y, Sugimoto K, Inui H, Fukusato T.Current pharmacological therapies for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol. 2015;21(13):3777-85. doi: 10.3748/wjg. v21.i13.3777</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Chalasani N, Younossi Z, Lavine J, Diehl A, Brunt E, Cusi K, Charlton M, Sanyal A. The diagnosis and management of non - alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012; 55(6):2005-23. doi: 10.1002/hep.25762</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Lewis J.D, Ferrara A, Peng T, Hedderson M, Bilker W, Quesenberry C, Vaughn D, Nessel L, Selby J, Strom B. Risk of Bladder Cancer Among Diabetic Patients Treated With Pioglitazone: Interim report of a longitudinal cohort study. Diabetes Care. 2011;34(4):916-22. doi: 10.2337/ dc10-1068</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Lomonaco R, Sunny N, Bril F, Cusi K. Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches. Drugs. 2013;73(1):1-14. doi: 10.1007/s40265-012-0004-0</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Haukeland J, Konopski Z, Eggesbø H, von Volkmann H, Raschpichler G, Bjøro K, Haaland T, Løberg E, Birkeland K. Metformin in patients with non - alcoholic fatty liver disease: A randomized, controlled trial. Scand J Gastroenterol. 2009;44(7):853-60. doi: 10.1080/ 00365520902845268</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Lavine J, Schwimmer J, van Natta M, Molleston J, Murray K, Rosenthal P, Abrams S, Scheimann A, Sanyal A, Chalasani N, et al. Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents. JAMA. 2011;305(16):1659-68. doi: 10.1001/jama.2011.520</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Strange R, Shipman K, Ramachandran S. Metabolic syndrome: A review of the role of vitamin D in mediating susceptibility and outcome. World J Diabetes. 2015;6(7):896-911. doi: 10.4239/wjd.v6.i7.896</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Katiyar S.K. Silymarin and skin cancer prevention: Anti - inflammatory, antioxidant and immunomodulatory effects (Review). Intern J Oncol. 2005;26:169-76. doi: 10.3892/ijo.26.1.169</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Deep G, Agarwal R. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev. 2010;29(3):447-63. doi: 10.1007/s10555-010-9237-0</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Lee J, Kim S, Kim H, Lee T, Jeong Y, Lee C, Yoon M, Na Y, Suh D, Park N, et al. Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells. J Cell Physiol. 2007;210(2):385-97. doi: 10.1002/jcp.20852</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Anon (2017) [online]. Available at: http://Al-Jassabi S, Saad A, Azirun M.S, Al-Omari A. The role of Silymarin in prevention of Alloxan - induced diabetes mellitus in Balb/C mice. American-Eurasian J Toxicol Sci. 2011;3(3):172-6 [Accessed 29 Nov. 2017].</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Anon (2017) [online]. Available at: http://WHO monographs on selected medicinal plants. Fructus Silybi Mariae. Vol. 2. Geneva: World Health Organization; 2002. P. 300-16 [Accessed 29 Nov. 2017].</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Malihi F, Hosseini-Tabatabaei A, Esmaily H, Khorasani R, Baeeri M, Abdollahi M. Improvement of inflammatory and toxic stress biomarkers by silymarin in a murine model of type one diabetes mellitus. Open Life Sci. 2009;4(3):369-80. doi: 10.2478/s11535-009-0014-4</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Liu J, Zhang M, Wang W, Grimsgaard S. Chinese herbal medicines for type 2 diabetes mellitus. Cochrane Database System Rev. 2002. doi: 10.1002/14651858.cd003642.pub2</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Del Ben M, Polimeni L, Baratta F, Pastori D, Loffredo L, Angelico F. Modern approach to the clinical management of non - alcoholic fatty liver disease. World J Gastroenterol. 2014;20(26):8341-50. doi: 10.3748/ wjg.v20.i26.8341</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial. Free Radical Biol Med. 2012;52(9):1658-65. doi: 10.1016/j.freeradbiomed.2012.02.008</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Marin V, Gazzin S, Gambaro S, Dal Ben M, Calligaris S, Anese M, Raseni A, Avellini C, Giraudi P, Tiribelli C, Rosso N. Effects of Oral Administration of Silymarin in a Juvenile Murine Model of Non - alcoholic Steatohepatitis. Nutrients. 2017;9(9):1006. doi: 10.3390/ nu9091006</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Hermann R, von Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Medica. 2012;78(13):1458-77. doi: 10.1055/s-0032-1315117</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Fan J, Jia J, Li Y, et al. Guidelines for the diagnosis and management of nonalcoholic fatty liver disease: Update 2010. J Digest Dis. 2011;12(1):38-44. doi: 10.1111/j.1751-2980.2010.00476.x</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Charlton M, Kasparova P, Weston S, Lindor K, Maor-Kendler Y, Wiesner R.H, Rosen C.B, Batts K.P. Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease. Liver Transplantation. 2001;7(7):608-14. doi: 10.1053/jlts.2001.25453</mixed-citation></ref></ref-list></back></article>
