Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3284010.26442/terarkh201890285-88Editorial articleПередовая статьяResearch ArticleClinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver diseaseКлинико-морфологические параллели полиморфизма гена PNPLA3 у пациентов с неалкогольной жировой болезнью печениTikhomirovaA SТихомироваАнна Сергеевна

аспирант каф. госпитальной терапии №2 лечебного факультета РНИМУ им. Н.И. Пирогова

dr.tikhomirovaas@gmail.comKislyakovV AКисляковВладимир Аркадьевич

к.м.н., доц. каф. госпитальной терапии №2 лечебного факультета РНИМУ им. Н.И. Пирогова

BaykovaI EБайковаИрина Евгеньевна

к.м.н., доц. каф. госпитальной терапии №2 лечебного факультета РНИМУ им. Н.И. Пирогова

NikitinI GНикитинИгорь Геннадиевич

д.м.н., проф., зав. каф. госпитальной терапии №2 лечебного факультета РНИМУ им. Н.И. Пирогова; директор ФГАУ «Лечебно-реабилитационный центр» Минздрава России

N.I. Pirogov Russian national research medical University, Ministry of health of RussiaФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииHigher Medical rehabilitation center, Ministry of health of RussiaФГАУ «Лечебно-реабилитационный центр» Минздрава России15022018902VOL 90, NO2 (2018)ТОМ 90, №2 (2018)858811042020Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32840

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its detection in the general population has reached a global scale. Despite the fact that in the early stages the disease is characterized by a relatively mild period, the development during its natural course of nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma causes deterioration of long-term forecast. Growing evidence indicates that NAFLD is a complex, multifaceted etiology, involving many factors, including genetic. In the present review, we focused on the genetic component of NAFLD, namely, the role of the PNPLA3 gene polymorphism in the development and course of the disease, and States its progression, such as non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma.

Неалкогольная жировая болезнь печени (НАЖБП) - наиболее распространенное хроническое заболевание печени; ее выявление в общей популяции достигло глобальных масштабов. Несмотря на то что на ранних стадиях заболевание характеризуется относительно мягким течением, развитие в ходе его естественного течения неалкогольного стеатогепатита, цирроза печени и гепатоцеллюлярной карциномы приводит к ухудшению долгосрочного прогноза. Все больше данных указывает на то, что НАЖБП имеет сложную, многогранную этиологию, включающую множество факторов, в том числе и генетические. В представленном обзоре мы сосредоточились на генетической составляющей НАЖБП, а именно - на роли полиморфизма гена PNPLA3 в развитии и течении заболевания, а также состояний ее прогрессирования, таких как неалкогольный стеатогепатит, цирроз печени и гепатоцеллюлярная карцинома.

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