Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3282210.26442/terarkh201890253-58Editorial articleПередовая статьяResearch ArticleUltrasound examination with contrast in the diagnosis of inflammatory bowel disease. The results of the pilot studyУльтразвуковое исследование с контрастированием в диагностике воспалительных заболеваний кишечника. Результаты пилотного исследованияFominV VФоминВиктор Викторович

член-корр. РАН, д.м.н., проф., проректор по лечебной работе, зав. каф. факультетской терапии №1 лечебного факультета

TernovoyS KТерновойСергей Константинович

академик РАН, д.м.н., проф., зав. каф. лучевой диагностики и лучевой терапии лечебного факультета

MakhovV MМаховВалерий Михайлович

д.м.н., проф. каф. факультетской терапии №1 лечебного факультета

IsaykinaM AИсайкинаМария Алексеевна

аспирант каф. факультетской терапии №1 лечебного факультета

manon_17@mail.ruDzhenzheraN AДженжераНадежда Александровна

к.м.н., зав. отд-нием ультразвуковой диагностики Университетской клинической больницы №1

TurkoT VТуркоТатьяна Васильевна

к.м.н., врач гастроэнтерологического отд-ния №2 Университетской клинической больницы

UgryumovaL NУгрюмоваЛидия Николаевна

к.м.н., зав. гастроэнтерологическим отде-нием №2 Университетской клинической больницы №1

BabenkoO VБабенкоОлег Васильевич

к.м.н., доц., гл. врач Университетской клинической больницы №1

I. M. Sechenov First Moscow state medical University, Ministry of Health of Russia (Sechenovskiy University)ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)15022018902VOL 90, NO2 (2018)ТОМ 90, №2 (2018)535811042020Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32822

Aim. Assessment of diagnostic significance of informativeness and security of ultrasonography with contrast enhancement drug SonoVue in the diagnosis of Crohn's disease (CD) and ulcerative colitis (UC). Materials and methods. The pilot conducted a prospective study which involved 15 patients with inflammatory bowel disease (IBD). All patients gave written consent to participate in the study and processing of personal data. The study included adult patients with an established diagnosis of UC and CD, with proven clinical activity of the disease. Activity was evaluated based on clinical and laboratory data on the scale of best (CDAI >150) for patients with CD and on a scale of Trulove-Witts (2-3 stage) and the Mayo index (DAI) for patients with UC. All the patients underwent colonoscopy with biopsy, ultrasound examination of abdominal cavity organs with the study of the vascularization of the intestinal wall (color Doppler, power Doppler, contrast study). Results. The use of contrast showed additional features in the instrumental evaluation of activity of inflammatory process, identification of complications and assessment of prognosis. Conclusion. The results of ultrasound of the bowel with contrast can be used to assess the activity and stage of disease in patients with UC or CD.

Цель исследования. Оценка диагностической значимости, информативности и безопасности ультразвукового исследования (УЗИ) с контрастным усилением препаратом Соновью (SonoVue) в диагностике болезни Крона (БК) и язвенного колита (ЯК). Материалы и методы. Проведено пилотное проспективное исследование, в котором приняли участие 15 пациентов с воспалительными заболеваниями кишечника (ВЗК). Все пациенты дали письменное согласие на участие в исследовании и обработку персональных данных. В исследование включали взрослых пациентов с установленным диагнозом ЯК и БК, с доказанной клинической активностью заболевания. Активность оценивалась на основании клинико-лабораторных данных по шкале Беста (CDAI >150) для пациентов с БК и по шкале Trulove-Witts (2-3-я стадия) и индексу Мейо (DAI) для пациентов с ЯК. Всем больным проведены колоноскопия с биопсией, УЗИ органов брюшной полости с исследованием васкуляризации стенки кишечника (цветной допплер, энергетический допплер, контрастное исследование). Результаты. Применение контрастирования продемонстрировало дополнительные возможности в инструментальной оценке активности воспалительного процесса, в выявлении осложнений и оценке прогноза заболевания. Заключение. Результаты УЗИ кишечника с контрастированием могут использоваться для оценки активности и стадии болезни у пациентов с БК и ЯК.

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