Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya3272410.26442/terarkh201890333-37Research ArticleVerification of zinc role in pathophysiology of chronic obstructive pulmonary diseaseShevcovaV IshevVI17@yandex.ruZujkovaA A-PashkovA N-KotovaJu A-ShevcovA N-Burdenko Voronezh State Medical University15032018903333711042020Copyright © 2018, Consilium Medicum2018Aim. Determination of the level of zinc and its fractions, as well as the enzyme neutrophilic elastase and albumin in persons suffering from chronic obstructive pulmonary disease (COPD), as well as smoking actively and passively. Materials and methods. The study involved 30 patients with a diagnosis of COPD and 90 healthy persons (60 of them smoking at the present time, 30 - no) who underwent spirometry and determination of zinc levels and its pools, albumin, and neutrophil elastase. All data are subject to statistical processing. Results. It is determined that the studied parameters differ significantly in the groups of smokers with COPD, healthy smokers and non-smokers, and correlate with the volume of forced exhalation for 1 second as a percentage of the due. Conclusion. The revealed regularities make it possible to consider the indicator "share of bound zinc fraction" introduced in the study as a screening criterion in diagnosing COPD in smokers.chronic obstructive pulmonary diseasescreening diagnosticssmokingzincхроническая обструктивная болезнь легкихскрининговая диагностикакурениецинк[Айсанов З.Р., Черняк А.В., Калманова Е.Н. Спирометрия в диагностике и оценке терапии хронической обструктивной болезни легких в общеврачебной практике. Пульмонология. 2014; 5: 101-110. http://doi.org/10.18093/0869-0189-2014-0-5-101-110][Agusti A, Sobradillo P, Celli B. Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale free networks, systems biology, and medicine. American Journal of Respiratory and Critical Care Medicine. 2011; 183:1129-1137.][Синцова С.В., Чичерина Е.Н. Табакокурение - эпидемия XXI века. Туберкулез и болезни легких. 2011; 3:8-11.][Черняев А.Л., Самсонова М.В. Воспаление при хронической обструктивной болезни легких: молекулярные основы патогенеза. Consilium medicinum. 2011; 5 (1): 9-14.][Gaur S.N, Goel N. Systemic Manifestations of COPD. Medicine Update. 2012; 22: 386-389.][Prasad A.S. Zinc is an oxidant and anti - inflammatory agent: its role in human health. Frontiers in nutrition. 2014;1(14): 1-10. https://doi.org/ 10.3389/fnut.2014.00014][Котова Ю.А., Зуйкова А.А., Страхова Н.В., Чернов А.В. Влияние цинка сульфата на состояние антиоксидантной системы у больных с артериальной гипертензией. Кардиоваскулярная терапия и профилактика. 2015; 14(S2): 142.][Щупакова А.Н., Окулич В.К., Беляева Л.Е., Прудников А.Р. Протеолитическая активность нейтрофильной эластазы как прогностический фактор развития заболеваний сердечно - сосудистой системы. Вестник ВГМУ. 2016: 15 (2): 17-26. https://doi.org/ 10.22263/2312-4156.2016.2.17]