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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">32378</article-id><article-id pub-id-type="doi">10.17116/terarkh20178912233-237</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A rationally grounded approach to treating gout with regard to its onset and course and the presence of comorbidity according to the European League against Rheumatism (EULAR 2016) recommendations</article-title><trans-title-group xml:lang="ru"><trans-title>Рационально-обоснованный подход к лечению подагры с учетом дебюта, течения и сочетанной патологии по материалам рекомендаций Европейской антиревматической лиги (EULAR 2016 г.)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tsurko</surname><given-names>V V</given-names></name><name xml:lang="ru"><surname>Цурко</surname><given-names>В В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gromova</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Громова</surname><given-names>М А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="ru">ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff id="aff3"><institution>ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России</institution></aff><pub-date date-type="pub" iso-8601-date="2017-12-20" publication-format="electronic"><day>20</day><month>12</month><year>2017</year></pub-date><volume>89</volume><issue>12-2</issue><issue-title xml:lang="en">VOL 89, NO12 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 89, №12-2 (2017)</issue-title><fpage>233</fpage><lpage>237</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/32378">https://ter-arkhiv.ru/0040-3660/article/view/32378</self-uri><abstract xml:lang="en"><p>The review analyzes in detail the management of gout, which takes into account its onset and course and the presence of comorbidity. Emphasis is placed on drug and non-drug treatments and urate-lowering therapy in patients with kidney dysfunction. Along with allopurinol, the urate-lowering drug febuxostat is first recommended in Russia. The purpose of this review is to notify physicians of the possibility of achieving the target uric acid levels when treating gout with hyperuricemia.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре подробно проанализировано ведение пациентов с подагрой, учитывающее дебют заболевания, течение и наличие сочетанной патологии. Основное внимание уделено фармакологическим, нефармакологическим методам лечения и применению уратснижающих препаратов у пациентов с нарушением функции почек. В России наряду с аллопуринолом впервые рекомендуется препарат с уратснижающим эффектом — фебуксостат. Цель обзора — довести до врачей информацию о возможности достижения целевого уровня мочевой кислоты при лечении подагры с гиперурикемией.</p></trans-abstract><kwd-group xml:lang="en"><kwd>gout</kwd><kwd>hyperuricemia</kwd><kwd>treatment</kwd><kwd>febuxostat</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>подагра</kwd><kwd>гиперурикемия</kwd><kwd>лечение</kwd><kwd>фебуксостат</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Hootman JM, Helmick CG. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum. 2006;54(1):226-229.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Насонова В.А., Барскова В.Г. Ранние диагностика и лечение подагры — научно обоснованное требование улучшения трудового и жизненного прогноза больных. Научно-практическая ревматология. 2004;1:5-7.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Luk AJ, Simkin PA. 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