Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya3237210.17116/terarkh20178912211-215Short CommunicationCommon variable immune deficiency in adults: focus on pulmonary complicationsFominaD S-BobrikovaE N-SinyavkinD O-ParshinV V-201220178912-221121510042020Copyright © 2017, Consilium Medicum2017Common variable immune deficiency is the most common form of a group of primary immunodeficiencies in adult patients. Pulmonary complications occupy leading positions. It is the development of recurrent bronchopulmonary inflammatory diseases that is considered to be one of the main causes of death and disability in patients with this disease. By presenting two clinical cases with long diagnostic delays, the authors try to attract the attention of specialists of related professions, which will minimize the development of irreversible complications in the patients.common variable immune deficiencyprimary immunodeficienciespulmonary complicationsintravenous immunoglobulinsобщая вариабельная иммунная недостаточностьпервичные иммунодефицитыпульмонологические осложненияиммуноглобулины для внутривенного введения[ESID Registry — Working definitions for clinical diagnosis of PID august 2016.][Латышева Е.А. Первичные иммунодефициты: состояние проблемы на сегодняшний день. JMF-центры в России. Вопросы современной педиатрии. 2013;12(6):73-77.][Dantas EO, Aranda CS, Nobre FA, Fahl K, et al. Medical awareness concerning primary immunodeficiency diseases in the city of São Paulo, Brazil. Journal of Allergy and Clinical Immunology 2012;129 iss 2 AB86. https://doi.org/10.1016/j.jaci.2011.12.648][Chapel Н, Prevot J, Gaspar H, Español T. Primary immune deficiencies — principles of care Frontiers in immunology. Front Immunol. 2014;5:627. https://doi.org/10.3389/fimmu.2014.00627][Кондратенко И.В. Первичные иммунодефициты. Медицинская иммунология. 2005;56(7):467-476 © 2005, СПб РО РААКИ.][Liesch Z, Hаnck C, Werth B, Kuhn M, et al. Diarrhea and weight loss in common variable immunodeficiency. Z Gastroenterol. 2004;42:599-603. https://doi.org/10.1055/s-2004-813184][Kalha I, Sellin JH. Common variable immunodeficiency and the gastrointestinal tract. Curr Gastroenterol Rep. 2004;6:377-383. https://doi.org/10.1007/s11894-004-0053-y][Chapel H, Lucas M, Lee M, Bjorkander J, et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood. 2008;112:277-286. https://doi.org/10.1182/blood-2007-11-124545][Guillaume B, Julien B. Cindy Barnig, et al. Thoracic Manifestations of Primary Humoral Immunodeficiency: A Comprehensive Review. RadioGraphics. 2009;29:1909-1920. https://doi.org/10.1148/rg.297095717][Agarwal S, Mayer L. Pathogenesis and treatment of gastrointestinal disease in antibody deficiency syndromes. J Allergy Clin Immunol. 2009;124:658-664. https://doi.org/10.1016/j.jaci.2009.06.018][Jolles S, Orange S, Gardulf A. Current treatment options with immunoglobulin G for the individualization of care in patients with primary immunodeficiency disease. British Society for Immunology. Clinical and Experimental Immunology. 2014;179:146-160. https://doi.org/10.1111/cei.12485][Cunningham — Rundles C. How I treat common variable immune deficiency. Blood .2010;116:7-15. https://doi.org/10.1182/blood-2010-01-254417][Латышева Т.В., Латышева Е.А., Мартынова И.А. Место иммуноглобулинов для внутривенного введения в современной клинической практике: Привиджен — новый 10% иммуноглобулин. Терапевтический архив. 2016;88(4):82-87.]