Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya3235810.17116/terarkh2017899120-127Review ArticleNon-vitamin K antagonist oral anticoagulants for heart diseasesKondratievaT B-PopovaL V-BokarevI N-1509201789912012710042020Copyright © 2017, Consilium Medicum2017Non-vitamin K antagonist oral anticoagulants (NОАСs) are highly effective drugs that prevent venous thrombosis and stroke in atrial fibrillation. Their use has difficulties that are associated with the need for laboratory control and with the influence of many factors on the activity of these medications. The emerged direct oral anticoagulants have some advantages over NOACs. Nevertheless, there are a number of pathological conditions, in which NOACs remain first-line drugs. 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