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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="brief-report" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">32304</article-id><article-id pub-id-type="doi">10.17116/terarkh201789872-76</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Short Communication</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Giant cell arteritis: Genetic and epigenetic aspects</article-title><trans-title-group xml:lang="ru"><trans-title>Гигантоклеточный артериит: генетические и эпигенетические аспекты</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Guliaev</surname><given-names>S V</given-names></name><name xml:lang="ru"><surname>Гуляев</surname><given-names>С В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Strizhakov</surname><given-names>L A</given-names></name><name xml:lang="ru"><surname>Стрижаков</surname><given-names>Л А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Novikov</surname><given-names>P I</given-names></name><name xml:lang="ru"><surname>Новиков</surname><given-names>П И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mukhin</surname><given-names>N A</given-names></name><name xml:lang="ru"><surname>Мухин</surname><given-names>Н А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fomin</surname><given-names>V V</given-names></name><name xml:lang="ru"><surname>Фомин</surname><given-names>В В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2017</year></pub-date><volume>89</volume><issue>8</issue><issue-title xml:lang="en">VOL 89, NO8 ()</issue-title><issue-title xml:lang="ru">ТОМ 89, №8 (2017)</issue-title><fpage>72</fpage><lpage>76</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/32304">https://ter-arkhiv.ru/0040-3660/article/view/32304</self-uri><abstract xml:lang="en"><p>The paper describes clinical cases in 2 patients (brothers) with giant cell arteritis. It analyzes the genetic and epigenetic aspects of the disease. The data available in the Russian and foreign literature are given.</p></abstract><trans-abstract xml:lang="ru"><p>Аннотация Представлены клинические наблюдения 2 больных (родные братья) с гигантоклеточным артериитом. Анализируются генетические и эпигенетические аспекты заболевания. Приводятся данные отечественной и зарубежной литературы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>systemic vasculitides</kwd><kwd>giant cell arteritis</kwd><kwd>Horton disease</kwd><kwd>temporal arteritis</kwd><kwd>genetic aspects</kwd><kwd>epigenetics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>системные васкулиты</kwd><kwd>гигантоклеточный артериит</kwd><kwd>болезнь Хортона</kwd><kwd>височный артериит</kwd><kwd>генетические аспекты</kwd><kwd>эпигенетика</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CGM, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DGI, Specks U, Stone JH, Takahashi K, Watts RA. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. 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