Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3220610.17116/terarkh201789172-77Editorial articleПередовая статьяShort CommunicationMyeloproliferative masks of multiple myeloma: A review of literature and clinical case reportsМиелопролиферативные «маски» множественной миеломы (обзор литературы и описание клинических наблюдений)RyzhkoV VРыжкоВ ВGrachevA EГрачевА ЕKlodzinskyA AКлодзинскийА АIvanovaT VИвановаТ ВSataevaM SСатаеваМ СGribanovaE OГрибановаЕ ОГематологический научный центр Минздрава России15012017891VOL 89, NO1 ()ТОМ 89, №1 (2017)727710042020Copyright ©; 2017, Consilium MedicumCopyright ©; 2017, ООО "Консилиум Медикум"2017Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32206

Concurrences of multiple myeloma with myeloproliferative diseases or secondary myeloid leukemoid reactions are rather rare. The paper describes 3 cases of multiple myeloma: the first case concurrent with neutrophilic leukocytosis; the second case with secondary erythropoetin-dependent erythrocytosis, and the third case with chronic myeloid leukemia. In such cases, an accurate diagnosis requires molecular testing, besides routine clinical and laboratory studies. The paper discusses therapeutic strategy in cases of a concurrence of 2 competing tumors of the blood system: to treat them simultaneously or the most aggressive tumor now, as well as a relationship between multiple myeloma and chronic myeloid leukemia, other myeloproliferative disorders, and secondary myeloid leukemoid reactions.

Аннотация Сочетания множественной миеломы с миелопролиферативными заболеваниями или вторичными лейкемоидными реакциями миелоидного типа достаточно редки. В статье описаны 3 случая множественной миеломы: один в сочетании с нейтрофильным лейкоцитозом, второй с вторичным эритропоэтинзависимым эритроцитозом и третий с хроническим миелолейкозом. Для установления точного диагноза в таких случаях, кроме стандартных клинических и лабораторных исследований, обязательными являются молекулярные исследования. Обсуждается терапевтическая стратегия в случаях сочетания 2 конкурирующих опухолей системы крови: лечить одновременно или наиболее агрессивную в настоящее время. Обсуждена взаимосвязь множественной миеломы и хронического миелоидного лейкоза, других миелопролиферативных заболеваний, лейкемоидных реакцих миелоидного типа.

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