Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3212110.17116/terarkh20168812109-115Editorial articleПередовая статьяReview ArticleEnoxaparin is a low-molecular-weight heparin with a complex chemical structure and various non-anticoagulant propertiesЭноксапарин — низкомолекулярный гепарин со сложной химической структурой и разнообразными неантикоагулянтными свойствамиZyryanovS KЗыряновС КUshkalovaE AУшкаловаЕ АРоссийский университет дружбы народов151220168812VOL 88, NO12 (2016)ТОМ 88, №12 (2016)10911510042020Copyright ©; 2016, Consilium MedicumCopyright ©; 2016, ООО "Консилиум Медикум"2016Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32121

The paper discusses the non-anticoagulant properties of unfractionated heparin and enoxaparin and their relation to their chemical structures. It is emphasized that enoxaparin has multiple, often interrelated, non-anticoagulant effects that can complement its antithrombotic activity and enhance the efficiency of therapy in patients receiving the drug for various indications. The realization of these effects requires the complex structure with the standard distribution of molecular weight (Mw) (average Mw, about 4500 Da, as well as Mw of less than 2000 Da (<20%), 2000 to 8000 Da (>68%), and more than 8000 Da (<18%), and with the standard content of 1.6-anhidro rings (15—25%), which is determined by the source of raw materials and by the production technology of the original drug and cannot be fully reproduced when designing its bioanalogues.

Аннотация В статье обсуждаются неантикоагулянтные свойства нефракционированного гепарина и эноксапарина и их зависимость от химической структуры. Подчеркивается, что эноксапарин дает множественные, часто взаимосвязанные, неантикоагулянтные эффекты, которые могут дополнять его антитромботическое действие и способствовать повышению эффективности терапии у пациентов, получающих препарат по разным показаниям. Для реализации этих эффектов необходима комплексная структура со стандартным распределением молекулярной массы (средняя около 4500 Да, в том числе менее 2000 Да <20%, от 2000 до 8000 Да >68%, более 8000 Да <18%) и стандартным содержанием 1,6-ангидроколец (15—25%), которая определяется источником сырья и технологией получения оригинального препарата и не может быть полностью воспроизведена в процессе разработки его биоаналогов.

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