Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3206210.17116/terarkh201688950-54Editorial articleПередовая статьяResearch ArticleAssociation of the -844G>A polymorphism in the catalase gene with the increased risk of essential hypertension in smokersАссоциация полиморфизма -844G>A гена каталазы с повышенным риском развития артериальной гипертонии у курильщиковBushuevaO YuБушуеваО ЮIvanovV PИвановВ ПRyzhaevaV NРыжаеваВ НPonomarenkoI VПономаренкоИ ВChurnosovM IЧурносовМ ИPolonikovA VПолониковА ВКурский государственный медицинский университет Минздрава РоссииБелгородский национальный исследовательский университет15092016889VOL 88, NO9 ()ТОМ 88, №9 (2016)505410042020Copyright ©; 2016, Consilium MedicumCopyright ©; 2016, ООО "Консилиум Медикум"2016Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32062

Aim. To investigate whether the functionally relevant -844G>A promotor polymorphism in the catalase (CAT) gene is associated with the development of essential hypertension (EH). Subjects and methods. The investigation enrolled 2,339 unrelated ethnic Russian people, including 1,269 EH patients and 770 apparently healthy individuals. Genotyping of CAT -844G>A (rs769214) polymorphism was performed using a TaqMan real-time polymerase chain reaction assay. Results. The -844A allele (odds ratio (OR)=1.31; 95% confidence interval (CI), 1.04 to 1.64; р=0.02) and the -844AA genotype (OR=1.41; 95% CI, 1.02 to 1.94; р=0.03) were found to be related to a higher risk of EH in the smokers. No association was found between this polymorphism and EH risk in the non-smokers. Conclusion. Smoking is a predisposing factor for development of EH in CAT -844AA genotype carriers.

Резюме Цель исследования. Изучение ассоциации функционально значимого промоторного полиморфизма -844G>A гена каталазы (САТ) с развитием артериальной гипертонии (АГ). Материалы и методы. В исследование включили 2339 неродственных индивидов русской национальности, включая 1269 больных АГ и 770 относительно здоровых индивидуумов. Генотипирование полиморфизма -844G>A (rs769214) гена САТ осуществляли методом полимеразной цепной реакции в реальном времени с использованием зондов TaqMan. Результаты. Обнаружено, что аллель -844А (отношение шансов — 1,31 при 95% доверительном интервале — ДИ от 1,04 до 1,64; р=0,02) и генотип -844АА (ОШ 1,41 при 95% ДИ от 1,02 до 1,94; р=0,03) ассоциированы с повышенным риском развития АГ у курильщиков. У некурящих индивидуумов ассоциация данного полиморфизма с риском развития АГ не обнаружена. Заключение. Курение является провоцирующим фактором риска развития АГ у носителей генотипа -844АА гена каталазы.

essential hypertensionoxidative stresscatalasegenetic polymorphismgene-environment interactionsартериальная гипертонияокислительный стресскаталазагенетический полиморфизмгенно-средовые взаимодействияDeStefano A, Gavras H, Heard-Costa N, Bursztyn M, Manolis A, Farrer L, Baldwin C, Gavras I, Schwartz F. Maternal component in the familial aggregation of hypertension. Clin Genet. 2001;60(1):13-21.Binder A. A review of the genetics of essential hypertension. CurOpin Cardiol. 2007;22(3):176-184.Rafiq S, Anand S, Roberts R. Genome-wide association studies of hypertension: have they been fruitful? J Cardiovasc Translational Res. 2010;3(3):189-196. doi:10.1007/s12265-010-9183-9Harrap SB. Hypertension: genes versus environment. Lancet. 1994;344(8916):169-171.Lacy F, O’Connor DT, Schmid-Schönbein GW. Plasma hydrogen peroxide production in hypertensives and normotensive subjects at genetic risk of hypertension. J Hypertens. 1998;16(3):291-303.Schulz E, Jansen T, Wenzel P, Daiber A, Münzel T. Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxidants Redox Signaling. 2008;10(6):1115-1126. doi:10.1089/ars.2007.1989Baradaran A, Nasri H, Rafieian-Kopaei M. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. J Res Med Scie. 2014;19(4).Dikalov S, Nazarewicz R, Bikineyeva A, Hilenski L, Lassègue B, Griendling K, Harrison D, Dikalova A. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxidants Redox Signaling. 2014;20(2):281-294. doi:10.1089/ars.2012.4918Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 4th ed. New York: Oxford University Press Inc.; 2007.van Remmen H, Williams M, Yang H, Walter C, Richardson A. Analysis of the transcriptional activity of the 5′flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice. J Cell Physiol. 1998;174(1):18-26.Hebert-Schuster M, Fabre EE, Nivet-Antoine V. Catalase polymorphisms and metabolic diseases. Cur Opin Clin Nutrition Metab Care. 2012;15(4):397-402. doi:10.1097/MCO.0b013e328354a326Jiang Z, Akey J, Shi J, Xiong M, Wang Y, Shen Y, Xu X, Chen H, Wu H, Xiao J, Lu D, Huang W, Jin L. A polymorphism in the promoter region of catalase is associated with blood pressure levels. Human Genet. 2001;109(1):95-98.Watanabe Y Metoki, H Ohkubo T, Katsuya T, Tabara Y, Kikuya M, Hirose T, Sugimoto K, Asayama K, Inoue R, Hara A, Obara T, Nakura J, Kohara K, Totsune K, Ogihara T, Rakugi H, Miki Τ, Imai Y. Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study. Hypertens Res. 2010;33(2):129-134. doi:10.1038/hr.2009.193Polonikov A, Ivanov V, Solodilova M, Khoroshaya I, Kozhuhov M, Ivakin V, Katargina L, Kolesnikova O. A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population. Disease Markers. 2008;24(2):119-126.Polonikov A, Ushachev D, Ivanov V, Churnosov M, Freidin M, Ataman A, Harbuzova V, Bykanova M, Bushueva O, Solodilova M. Altered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesis. J Hypertens. 2015;33(11):2265-2277. doi:10.1097/HJH.0000000000000699Bushueva O, Solodilova M, Churnosov M, Ivanov V, Polonikov A. The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility. Int J Hypertens. 2014. doi:10.1155/2014/712169Bushueva O, Solodilova M, Ivanov V, Polonikov A. Gender-specific protective effect of the −463G>A polymorphism of myeloperoxidase gene against the risk of essential hypertension in Russians. J Am Soc Hypertens. 2015;9(11):902-906. doi:10.1016/j.jash.2015.08.006Packer BR, Yeager M, Burdett L et al. SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res. 2006;34(suppl 1):D617-D621.Васильева Ю.И., Бушуева О.Ю., Жабин С.Н., Иванов С.В., Полоников А.В. Курение как провоцирующий фактор развития диабетической ангиопатии нижних конечностей у мужчин с генотипом 677ТТ гена метилентетрагидрофолатредуктазы. Клиническая медицина. 2015;93(7):45-49.Бушуева О.Ю., Стецкая Т.А., Корогодина Т.В., Иванов В.П., Полоников А.В. Влияние полиморфизма E298D гена эндотелиальной синтазы оксида азота на риск развития мозгового инсульта в зависимости от статуса курения. Генетика. 2015;51(2):256-262.Polonikov AV, Ivanov VP, Solodilova MA, Kozhuhov MA, Panfilov VI. Tobacco smoking, fruit and vegetable intake modify association between -21A>T polymorphism of catalase gene and risk of bronchial asthma. J Asthma. 2009;46(3):217-224. doi:10.1080/02770900802492103Pryor WA, Stone K, Zang LY, Bermúdez E. Fractionation of aqueous cigarette tar extracts: fractions that contain the tar radical cause DNA damage. Chem Res Toxicol. 1998;11(5):441-448.Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature molecular and cellular mechanisms. Hypertension. 2003;42(6):1075-1081.Sorokin AV, Kotani K, Bushueva OY, Polonikov AV. Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russian. Cardiol Young. 2015:1-6.Reiter RJ. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J. 1995;9(7):526-533.Redón J, Oliva MR, Tormos C, Giner V, Chaves J, Iradi A, Sáez GT. Antioxidant activities and oxidative stress byproducts in human hypertension. Hypertension. 2003;41(5):1096-1101.Quan F, Korneluk RG, Tropak MB, Gravel RA. Isolation and characterization of the human catalase gene. Nucleic Acids Res. 1986;14(13):5321-5335.Crawford A, Fassett RG, Geraghty DP, Kunde DA, Ball MJ, Robertson IK, Coombes JS. Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease. Gene. 2012;501(2):89-103. doi:10.1016/j.gene.2012.04.011Hebert-Schuster M, Cottart CH, Laguillier-Morizot C, Raynaud-Simon A, Golmard JL, Cynober L, Beaudeux JL, Fabre EE, Nivet-Antoine V. Catalase rs769214 SNP in elderly malnutrition and during renutrition: is glucagon to blame? Free Radical Biol Med. 2011;51(8):1583-1588. doi:10.1016/j.freeradbiomed.2011.07.016Nadif R, Mintz M, Jedlicka A, Bertrand JP, Kleeberger SR, Kauffmann F. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. Free Radical Res. 2005;39(12):1345-1350.