Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya32009Editorial articleПередовая статьяReview ArticleInterleukin-6 inhibition and cardiovascular disease in patients with rheumatoid arthritisИнгибирование интерлейкина-6 и сердечно-сосудистая патология у больных ревматоидным артритомPopkovaT VПопковаТ ВNovikovaD SНовиковаД СNasonovE LНасоновЕ ЛНаучно-исследовательский институт ревматологии им. В.А. Насоновой15052016885VOL 88, NO5 ()ТОМ 88, №5 (2016)9310110042020Copyright ©; 2016, Consilium MedicumCopyright ©; 2016, ООО "Консилиум Медикум"2016Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/32009

Rheumatoid arthritis (RA) is a disease conferring a high risk for cardiovascular events (CVE). Systemic inflammation underlying RA favors the development of CVE. The safety of biological agents acting on the cardiovascular system has been inadequately investigated. On the one hand, they decrease RA activity and, on the other, may increase the risk of CVE. This review analyzes the literature data predominantly published in recent years on the effect of an IL-6 receptor inhibitor on the cardiovascular system. Tocilizumab is shown to be a promising agent to reduce cardiovascular risk. The findings need to be clinically verified. Long-term prospective investigations should be conducted to determine more exactly the impact of IL-6 receptor inhibition on the development of CVE.

Ревматоидный артрит (РА) — заболевание с высоким риском развития сердечно-сосудистых осложнений (ССО). Системное воспаление, лежащее в основе РА, способствует развитию ССО. Безопасность генно-инженерных биологических препаратов в отношении влияния на сердечно-сосудистую систему изучена недостаточно. С одной стороны, они уменьшают активность РА, с другой, могут увеличивать риск развития ССО. В настоящем обзоре проанализированы данные литературы, преимущественно последних лет, касающиеся влияния ингибитора рецепторов интерлейкина-6 (рИЛ-6) на сердечно-сосудистую систему. Показано, что тоцилизумаб является перспективным средством для снижения кардиоваскулярного риска. Полученные результаты нуждаются в клиническом подтверждении. Необходимо проведение проспективных долгосрочных исследований, которые позволят более точно определить влияние ингибирования рИЛ-6 на развитие ССО.

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