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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31937</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Successes and unsolved problems in the study of celiac disease</article-title><trans-title-group xml:lang="ru"><trans-title>Успехи и нерешенные проблемы в изучении целиакии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Osipenko</surname><given-names>M F</given-names></name><name xml:lang="ru"><surname>Осипенко</surname><given-names>М Ф</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shrainer</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Шрайнер</surname><given-names>Е В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Parfenov</surname><given-names>A I</given-names></name><name xml:lang="ru"><surname>Парфенов</surname><given-names>А И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">«Новосибирский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Институт химической биологии и фундаментальной медицины СО РАН</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">«Московский клинический научно-практический центр» Департамента здравоохранения Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2016</year></pub-date><volume>88</volume><issue>2</issue><issue-title xml:lang="en">VOL 88, NO2 ()</issue-title><issue-title xml:lang="ru">ТОМ 88, №2 (2016)</issue-title><fpage>97</fpage><lpage>100</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31937">https://ter-arkhiv.ru/0040-3660/article/view/31937</self-uri><abstract xml:lang="en"><p>The review gives current views on the problem of celiac disease (gluten enteropathy). It presents the pathogenetic components of pathology development, associations with the specific features of the microflora in different parts of the gastrointestinal tract, as well as groups at risk for this pathology. The idea on other types of gluten intolerance is briefly given. Current elaborated approaches to gluten enteropathy therapy are provided.</p></abstract><trans-abstract xml:lang="ru"><p>Аннотация В обзоре даны современные взгляды на проблему целиакии (глютеновой энтеропатии). Представлены патогенетические звенья развития патологии, ассоциации с особенностями микрофлоры различных отделов желудочно-кишечного тракта, приведены группы риска формирования данной патологии. Коротко дано представление о других вариантах непереносимости глютена. Приведены современные разрабатываемые подходы к терапии глютеновой энтеропатии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>celiac disease</kwd><kwd>gluten enteropathy</kwd><kwd>gluten intolerance</kwd><kwd>gliadin</kwd><kwd>zonulin</kwd><kwd>transglutaminase</kwd><kwd>endomysium</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>целиакия</kwd><kwd>глютеновая энтеропатия</kwd><kwd>непереносимость глютена</kwd><kwd>глиадин</kwd><kwd>зонулин</kwd><kwd>трансглутаминаза</kwd><kwd>эндомизий</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Sapone A, Bai JC, Ciacci C, Dolinsek J et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classication. BMC Med. 2012;10:13. doi:10.1186/1741-7015-10-13.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>McAllister CS, Kagnoff MF. The immunopathogenesis of celiac disease reveals possible therapies beyond the gluten-free diet. 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