Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya31823Editorial articleПередовая статьяReview ArticleMineralocorticoid receptor antagonists in the treatment of patients with chronic heart failure. Positions in 2015Антагонисты минералокортикоидных рецепторов в терапии больных с хронической сердечной недостаточностью. Позиции 2015 г.OsmolovskayaYu FОсмоловскаяЮ ФZhirovI VЖировИ ВTereshchenkoS NТерещенкоС ННИИ кардиологии им А.Л. МясниковаФГБУ РКНПК Минздрава России, МоскваФГБУ РКНПК Минздрава России, МоскваНИИ кардиологии им А.Л. Мясникова15092015879VOL 87, NO9 ()ТОМ 87, №9 (2015)778310042020Copyright ©; 2015, Consilium MedicumCopyright ©; 2015, ООО "Консилиум Медикум"2015Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/31823

Mineralocorticoid receptor antagonists (MCRA) are part of standard medical therapy for heart failure (HF). The clinical efficacy of MCRA in patients with systolic HF has been proven by randomized clinical trials. The efficacy of this drug group in patients with chronic HF with preserved left ventricular systolic function and the advent and practical introductions of safer new-generation MCRA remain to be answered.

Антагонисты минералокортикоидных рецепторов (АМКР) являются частью стандартной медикаментозной терапии больных с сердечной недостаточностью (СН). Клиническая эффективность АМКР доказана в рандомизированных клинических исследованиях у пациентов с систолической СН. Остается открытым вопрос об эффективности данной группы препаратов у больных с хронической СН с сохраненной систолической функцией левого желудочка, а также появление и внедрение в практику более безопасных АМКР нового поколения.

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