Terapevticheskii arkhiv

Терапевтический архив

0040-36602309-5342

LLC Obyedinennaya Redaktsiya

31809

Editorial article

Передовая статья

Research Article

Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus

Факторы роста и конечные продукты гликирования у больных с различными формами ишемической болезни сердца и сахарным диабетом 2-го типа

Ivannikova

E V

Иванникова

Е В

Kalashnikov

V Yu

Калашников

В Ю

Smirnova

O M

Смирнова

О М

Kononenko

I V

Кононенко

И В

Kuznetsov

A B

Кузнецов

А Б

Terekhin

S A

Терёхин

С А

«Эндокринологический научный центр» Минздрава России

15102015

8710

VOL 87, NO10 (2015)

ТОМ 87, №10 (2015)

192510042020

2015

Consilium Medicum

ООО "Консилиум Медикум"

https://creativecommons.org/licenses/by-nc-sa/4.0

https://ter-arkhiv.ru/0040-3660/article/view/31809

Aim. To determine the levels of growth factors and glycation end products in patients with different forms of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Subjects and methods. A total of 134 patients with CHD and T2DM, including 38 patients with non-ST-elevation acute coronary syndrome (ACS), were examined. The arterial and venous serum levels of basic fibroblast growth factor-β (FGF-β), transforming growth factor-β (TGF-β), placental growth factor (PlGF), advanced glycation end products (AGEs) and their receptors (RAGE) were estimated in all the patients. Results. A direct correlation was found between the degree of arterial stenosis and the level of growth factors and AGEs in the patients with T2DM; there was also a direct correlation of the examined factors with lipid metabolic parameters. There was a significant two-fold increase in FGF-β, PlGF, and RAGE levels in the patients with ACS. Conclusion. Hyperglycemia was found to negatively affect the progression of atherosclerotic changes in the vessel wall and on that of fibrotic processes.

Цель исследования. Определение уровня факторов роста и конечных продуктов гликирования у больных с различными формами ишемической болезни сердца (ИБС) и сахарным диабетом 2-го типа (СД-2). Материалы и методы. Обследовали 134 пациента с ИБС и СД-2, в том числе 38 больных с острым коронарным синдромом (ОКС) без подъема сегмента ST. У всех определяли содержание основного фактора роста фибробластов (β-FGF), трансформирующего фактора роста (TGF-β), плацентарного фактора роста (PLGF), конечных продуктов гликирования (AGE) и их рецепторов (RAGE) в сыворотке артериальной и венозной крови. Результаты. Выявлена прямая корреляция между степенью стеноза артерий и уровнем факторов роста, AGE у пациентов с СД-2, а также прямая корреляция исследуемых факторов с показателями липидного обмена. Установлено достоверное двукратное повышение уровней β-FGF, PLGF, RAGE у пациентов с ОКС. Заключение. Выявлено негативное влияние гипергликемии на прогрессирование атеросклеротических изменений в стенке сосудов и процессов фиброза.

fibroblast growth factorsintima-media complexglycation end productsdiabetes mellitusatherosclerosis

факторы роста фибробластовкомплекс интима—медиаконечные продукты гликированиясахарный диабетатеросклероз

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