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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31802</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The specific features of diagnosis of mixed-phenotype acute leukemia: A combination of B-cell antigen expressions according to the results of flow cytometry and morphological markers of myeloid differentiation in blast cells: A clinical case</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности диагностики острого лейкоза со смешанным фенотипом: сочетание экспрессии В-клеточных антигенов по результатам проточной цитометрии и морфологических маркеров миелоидной дифференцировки в бластных клетках</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gritsaev</surname><given-names>S V</given-names></name><name xml:lang="ru"><surname>Грицаев</surname><given-names>С В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kostroma</surname><given-names>I I</given-names></name><name xml:lang="ru"><surname>Кострома</surname><given-names>И И</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ryadnova</surname><given-names>G M</given-names></name><name xml:lang="ru"><surname>Ряднова</surname><given-names>Г М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tiranova</surname><given-names>S A</given-names></name><name xml:lang="ru"><surname>Тиранова</surname><given-names>С А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chubukina</surname><given-names>Zh V</given-names></name><name xml:lang="ru"><surname>Чубукина</surname><given-names>Ж В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Balashova</surname><given-names>V A</given-names></name><name xml:lang="ru"><surname>Балашова</surname><given-names>В А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zenina</surname><given-names>M N</given-names></name><name xml:lang="ru"><surname>Зенина</surname><given-names>М Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Martynkevich</surname><given-names>I S</given-names></name><name xml:lang="ru"><surname>Мартынкевич</surname><given-names>И С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Potikhonova</surname><given-names>N A</given-names></name><name xml:lang="ru"><surname>Потихонова</surname><given-names>Н А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Abdulkadyrov</surname><given-names>K M</given-names></name><name xml:lang="ru"><surname>Абдулкадыров</surname><given-names>К М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">«Российский НИИ гематологии и трансфузиологии» ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2015</year></pub-date><volume>87</volume><issue>7</issue><issue-title xml:lang="en">VOL 87, NO7 ()</issue-title><issue-title xml:lang="ru">ТОМ 87, №7 (2015)</issue-title><fpage>97</fpage><lpage>100</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31802">https://ter-arkhiv.ru/0040-3660/article/view/31802</self-uri><abstract xml:lang="en"><p>This rare type of acute leukemia, blast cells of which express myeloid and/or lymphoid markers, is mainly diagnosed using flow cytometric findings. The paper describes a clinical case of mixed-phenotype acute leukemia, in which B-cell lymphoid antigen expressions were revealed by a flow cytometric technique, while bone marrow morphological specimens showed the signs of myeloid differentiation specific to blast cells. It is concluded that there is a need for a comprehensive examination of patients with new-onset acute leukemia and for an aggregate analysis of flow cytometric results with morphological and cytochemical findings.</p></abstract><trans-abstract xml:lang="ru"><p>Диагностика редкого варианта острого лейкоза, бластные клетки которого экспрессируют миелоидные и/или лимфоидные маркеры, осуществляется преимущественно по данным проточной цитометрии. Приведен клинический случай острого лейкоза со смешанным фенотипом, при котором методом проточной цитометрии выявлена экспрессия В-лимфоидных антигенов, в то время как в морфологических препаратах костного мозга обнаружены признаки, типичные для бластных клеток миелоидной направленности. Сделано заключение о необходимости комплексного обследования больных с впервые выявленным острым лейкозом и совокупным анализом результатов проточной цитометрии с данными морфологического и цитохимического исследований.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute myeloid leukemia</kwd><kwd>mixed-phenotype</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острый лейкоз</kwd><kwd>смешанный фенотип</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellstrom-Lindberg E, Tefferi A, Bloomfield CD. 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