<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="editorial" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31776</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Editorial</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Comorbidity of cardiovascular diseases and cancers: Problems in the diagnosis of cardiotoxic effects of chemo- and radiation therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Коморбидность сердечно-сосудистых и онкологических заболеваний: проблемы диагностики кардиотоксических эффектов химио- и лучевой терапии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chazova</surname><given-names>I E</given-names></name><name xml:lang="ru"><surname>Чазова</surname><given-names>И Е</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Oshchepkova</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Ощепкова</surname><given-names>Е В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kantorova</surname><given-names>A Yu</given-names></name><name xml:lang="ru"><surname>Канторова</surname><given-names>А Ю</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Российский кардиологический научно-производственный комплекс» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2015</year></pub-date><volume>87</volume><issue>9</issue><issue-title xml:lang="en">VOL 87, NO9 ()</issue-title><issue-title xml:lang="ru">ТОМ 87, №9 (2015)</issue-title><fpage>4</fpage><lpage>10</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31776">https://ter-arkhiv.ru/0040-3660/article/view/31776</self-uri><abstract xml:lang="en"><p>Cardiovascular diseases (CVD) and cancers are the leaders in their prevalence and the major causes of death in economically developed countries, determining their high sociomedical significance in society. Improvement of methods for the early diagnosis and treatment of cancers has contributed to increases in relapse-free survival and life expectancy in these patients. At the same time, the new problems have emerged particularly in the development of various cardiovascular events/diseases when treating cancer, which may predict worse prognosis in patients and be an independent cause of death. To search for new markers of cardiotoxicity at early stages and to develop effective methods for the prevention and personalized treatment of cancer and CVD are the problems that can be solved only by joint efforts of cardiologists and oncologists.</p></abstract><trans-abstract xml:lang="ru"><p>Сердечно-сосудистые заболевания (ССЗ) и онкологические заболевания (ОЗ) занимают лидирующие позиции по распространенности и причинам смерти в экономически развитых странах, что определяет их высокую медико-социальную значимость для общества. Совершенствование методов ранней диагностики и лечения ОЗ способствовало увеличению безрецидивной выживаемости и продолжительности жизни этих больных. Вместе с тем появились новые проблемы, в частности развитие различных сердечно-сосудистых осложнений/заболеваний при лечении ОЗ, которые могут ухудшать прогноз у больного и быть самостоятельной причиной смерти. Поиск новых маркеров кардиотоксичности на ранних стадиях, разработка эффективных методов профилактики и персонифицированного лечения больного с ОЗ и ССЗ — проблемы, которые могут быть решены только совместными усилиями кардиологов и онкологов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cardiovascular disease</kwd><kwd>cancers</kwd><kwd>cardiotoxicity</kwd><kwd>comorbidity</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>онкологические заболевания</kwd><kwd>кардиотоксичность</kwd><kwd>коморбидность</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Информационный бюллетень №297 СМИ ВОЗ Февраль 2012 г. Russian (Informacionnyj bjulleten’ N297 SMI VOZ Fevral’ 2012 g.).</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hong RA, Limura T, Sumida KN, Eager RM. Cardio-Oncology/Onco-Cardiology. Clin Cardiol. 2010;33:733-737.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Yeh ETH, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009;53:2231-2247.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer. 2003;97:2869-2879.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Seidman A, Hudis C, Pierri MK et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol. 2002;20: 1215-1221.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Giordano SH, Booser DJ, Murray JL et al. A detailed evaluation of cardiac toxicity: a phase II study of doxorubicin and one- or three- hour- infusion paclitaxel in patients with metastatic breast cancer. Clin CancerRes. 2002;8:3360-3368.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>van Dalen EC, Caron HN, Dickinson HO et al. Cardioprotective interventions for cancer patients receiving anthracyclines.Cochrane Database Syst Rev 2005; CD003917. http://www.cochrane.org. Accessed April 16, 2008.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Hensley ML, Hagerty KL, Kewalramani T et al. American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J Clin Oncol. 2009;27:127-145.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>van Dalen EC, van der Pal HJH, Bakker PJM et al. Cumulative incidence and risk factors of mitoxantrone-induced cardiotoxicity in children: a systematic review. Eur J Cancer. 2004;40:643-652.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Guglin M, Hartlage G, Reynolds C et al. Trastuzumab-induced cardiomyopathy: not as benign as it looks? A retrospective study. J Card Fail. 2009;15:651-657.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Ewer MS, Vooletich MT, Durand J et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol. 2005;23:7820-7826.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Perez EA, Koehler M, Byrne J et al. Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc. 2008;83:679-686.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Atallah E, Durand J, Kantarjian H et al. Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood. 2007;110:1233-1237.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Khakoo AY, Kassiotis CM, Tannir N et al. Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer. 2008;112:2500-2508.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Chu TF, Rupnick MA, Kerkela R et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007;370: 2011-2019.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Kantarjian H, Cortes J, Kim D et al. Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up. Blood. 2009;113: 6322-6329.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Gottdiener JS, Appelbaum FR, Ferrans VJ et al. Cardiotoxicity associated with high-dose cyclophosphamide therapy. Arch Intern Med. 1981;141:758-763.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Sonnenblick M, Rosin A. Cardiotoxicity of interferon. A review of 44 cases. Chest. 1991;99:557-561.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Miller KD, Chap LI, Holmes FA et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol. 2005;23:792-799.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Van Cutsem E, Hoff PM, Blum JL et al. Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with 5-fluorouracil. Ann Oncol. 2002;13:484-485.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Ang C, Kornbluth M, Thirlwell MP et al. Capecitabine-induced cardiotoxicity: case report and review of the literature. Curr Oncol. 2010;17:59-63.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Tsibiribi P, Descotes J, Lombard-Bohas C et al. Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease. BullCancer. 2006;93:E27-E30.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Schwarzer S, Eber B, Greinix H et al. Non-Q-wave myocardial infarction associated with bleomycin and etoposide chemotherapy. Eur Heart J. 1991;12:748-750.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Yano S, Shimada K. Vasospastic angina after chemotherapy by with carboplatin and etoposide in a patient with lung cancer. Jpn Circ J. 1996;60:185-188.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Swerdlow AJ, Higgins CD, Smith P et al. Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst. 2007;99:206-214.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Subar M, Muggia FM. Apparent myocardial ischemia associated with vinblastine administration. Cancer Treat Rep. 1986;70: 690-691.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Scappaticci FA, Skillings JR, Holden SN et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst. 2007;99: 1232-1239.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Escudier B, Eisen T, Stadler WM et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125-134.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Arbuck SG, Strauss H, Rowinsky E et al. A reassessment of cardiac toxicity associated with Taxol. J Natl Cancer Inst Monogr. 1993;15:117-130.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Lee RE, Lotze MT, Skibber JM et al. Cardiorespiratory effects of immunotherapy with interleukin-2. J Clin Oncol. 1989;7:7-20.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Soignet SL, Frankel SR, Douer D et al. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol. 2001;19:852-3860.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>McLellan RA, Drobitch RK, Monshouwer M et al. Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human. Drug Metab Dispos. 1996;24:1134-1138.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Fang J, Gorrod JW. Metabolism, pharmacogenetics, and metabolic drug-drug interactions of antipsychotic drugs. Cell Mol Neurobiol. 1999;19:491-510.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Reykdal S, Sham R, Kouides P. Cytarabine-induced pericarditis: a case report and review of the literature of the cardio-pulmonary complications of cytarabine therapy. Leuk Res. 1995;19:141-144.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Palumbo A, Rajkumar SV, Dimopoulos MA et al. Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia. 2008;22:414-423.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960-1966.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Olsen EA, Kim YH, Kuzel TM et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol. 2007;25: 3109-3115.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Brookes L. National Health and Nutrition Examination Survey (NHANES) data on hypertension. In: American Society of Hypertension 18th Annual Scientific Session, 2003.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Whitworth JA, Mangos GJ, Kelly JJ. Cushing, cortisol and cardiovascular disease. Hypertension. 2000;36:912-916.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Oparil S, Zaman MA, Calhoun DA. Pathogenesis of hypertension. AnnIntern Med. 2003;139:761-776.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Grossman EMF. Management of drug-induced and iatrogenic hypertension. In: Hypertension primer. 3d ed. Dallas, TX: Lippincott Williams &amp; Wilkins. 2003:516-519.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Veinot JP, Edwards WD. Pathology of radiation-induced heart disease: a surgical and autopsy study of 27 cases. Hum Pathol. 1996;27:766-773.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Heidenreich PA, Hancock SL, Vagelos RH et al. Diastolic dysfunction after mediastinal irradiation. Am Heart J. 2005;150: 977-982.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Gyenes G, Fornander T, Carlens P et al. Detection of radiation-induced myocardial damage by technetium-99m sestamibi scintigraphy. Eur JNucl Med. 1997;24:286-292.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Cuzick J, Stewart H, Rutqvist L et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol. 1994;12:447-453.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Hooning MJ, Botma A, Aleman BMP et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst. 2007;99:365-375.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Dolci A, Dominici R, Cardinale D et al. Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: systematic review of the literature and recommendations for use. Am J Clin Pathol. 2008;130(5):688-695.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Cardinale D, Sandri MT, Martinoni A et al. Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy. J AmColl Cardiol. 2000;36(2):517-522.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Cardinale D, Sandri MT, Colombo A et al. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation. 2004;109:2749-2754.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Cаржевский В.О., Колесникова Д.С., Мельниченко В.Я., Тюрин В.П. Кардиотоксичность высокодозной химиотерапии и аутологичной трансплантации костного мозга при онкогематологических заболеваниях. Клиническая онкогематология. 2013;6(3):324-332.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Auner HW, Tinchon C, Linkesch W et al. Prolonged monitoring of troponin T for the detection of anthracycline cardiotoxicity in adults with hematological malignancies. Ann Hematol. 2003;82(4):218-222.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Cardinale D, Colombo A, Sandri MT et al. Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. Circulation. 2006;114:2474-2481.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Suzuki T, Hayashi D, Yamazaki T et al. Elevated B-type natriuretic peptide levels after anthracycline administration. Am Heart J. 1998;136(2):362-363.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Nousiainen T, Jantunen E, Vanninen E et al. Acute neurohumoral and cardiovascular effects of idarubicin in leukemia patients. Eur J Haematol. 1998;61(5):347-353.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Horacek JM, Pudil R, Tichy M et al. Biochemical markers and assessment of cardiotoxicity during preparative regimen and hematopoietic cell transplantation in acute leukemia. Exp Oncol. 2007;29(3):243-247.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Snowden JA, Hill GR, Hunt P et al. Assessment of cardiotoxicity during hematopoietic cell transplantation with plasma brain natriuretic peptide. Bone MarrowTransplant. 2000;26(3):309-313.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Zver S, Zadnik V, Bunc M et al. Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007;85(5):408-414.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Munker R, Lazarus HM, Atkinson K. The BMT Data Book. 2nd ed. Cambridge: Cambridge University Press; 2009:237.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Kupari M, Volin L, Suokas A et al. Cardiac involvement in bone marrow transplantation: electrocardiographic changes, arrhythmias, heart failure and autopsy findings. Bone Marrow Transplant. 1990;5(2):91-98.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Styler MJ, Topolsky DL, Crilley PA et al. Transient high grade heart block following autologous bone marrow infusion. Bone Marrow Transplant. 1992;10(5):435-438.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Chung T, Lim WC, Sy R et al. Subacute cardiac toxicity following autologous haematopoietic stem cell transplantation in patients with normal cardiac function. Heart. 2008;94(7):911-918.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Pihkala J, Saarinen UM, Lundstrom U et al. Effects of bone marrow transplantation on myocardial function in children. Bone Marrow Transplant. 1994;13(2):149-155.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Zver S, Zadnik V, Cernelc P et al. Cardiac toxicity of high-dose cyclophosphamide and melphalan in patients with multiple myeloma treated with tandem autologous hematopoietic stem cell transplantation. Int JHematol. 2008;88(2):227-236.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Минимальные клинические рекомендации Европейского общества медицинской онкологии (ESMO). M.; 2010:428.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Keefe DL. Trastuzumab-associated cardiotoxicity. Cancer. 2002;95:1592-1600.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Ganz WI, Sridhar KS, Ganz SS et al. Review of tests for mon- itoring doxorubicin-induced cardiomyopathy. Oncology. 1996;53:461-470.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>van Dalen EC, van den Brug M, Caron HN et al. Anthracycline-induced cardiotoxicity: comparison of recommendations for monitoring cardiac function during therapy in paediatric oncology trials. Eur J Cancer. 2006;42:3199-3205.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Steinherz LJ, Graham T, Hurwitz R et al. Guidelines for cardiac monitoring of children during and after anthracycline therapy: report of the Cardiology Committee of the Childrens Cancer Study Group. Pediatrics. 1992;89(5 pt 1):942-949.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Guarneri V, Lenihan DJ, Valero V et al. Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson Cancer Center experience. J Clin Oncol. 2006;24: 4107-4115.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Nousiainen T, Vanninen E, Jantunen E et al. Natriuretic peptides during the development of doxorubicin-induced left ventricular diastolic dysfunction. J Intern Med. 2002;251:228-234.</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Donmez A, Zoghi M, Cagirgan S et al. The effect of hematopoietic progenitor cells’ temperature on cardiac arrhythmias in patients given peripheral blood progenitor cells. Transfus Apher Sci. 2006;34(3):245-251.</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Nakamae H, Tsumura K, Terada Y et al. Notable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone. Cancer. 2005;104:2492-2498.</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Silber JH, Cnaan A, Clark BJ et al. Enalapril to prevent cardiac function decline in long-term survivors of pediatric cancer exposed to anthracyclines. J Clin Oncol. 2004;22(5):820-828.</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Lipshultz SE, Lipsitz SR, Sallan SE et al. Long-term enalapril therapy for left ventricular dysfunction in doxorubicin-treated survivors of childhood cancer. J Clin Oncol. 2002;20(23):4517-4522.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Kakavas PW, Ghalie R, Parrillo JE et al. Angiotensin converting enzyme inhibitors in bone marrow transplant recipients with depressed left ventricular function. Bone Marrow Transplant. 1995;15(6):859-861.</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Bosch X, Esteve J, Sitges M et al. Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial. J Card Fail. 2011;17(8):643-648.</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>De Angelis A, Piegari E, Cappetta D et al. Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation. 2010;121:276-292.</mixed-citation></ref></ref-list></back></article>
