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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31723</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Workplace stress and its impact on the 16-year risk of myocardial infarction and stroke in an open female population aged 25—64 years in Russia/Siberia (WHO MONICA-psychosocial program)</article-title><trans-title-group xml:lang="ru"><trans-title>Стресс на работе и его влияние на 16-летний риск развития инфаркта миокарда, инсульта в открытой популяции среди женщин 25—64 лет в России/Сибири (программа ВОЗ «MONICA-психосоциальная»)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gafarov</surname><given-names>V V</given-names></name><name xml:lang="ru"><surname>Гафаров</surname><given-names>В В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Panov</surname><given-names>D O</given-names></name><name xml:lang="ru"><surname>Панов</surname><given-names>Д О</given-names></name></name-alternatives><xref ref-type="aff" rid="aff5"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gromova</surname><given-names>E A</given-names></name><name xml:lang="ru"><surname>Громова</surname><given-names>Е А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gagulin</surname><given-names>I V</given-names></name><name xml:lang="ru"><surname>Гагулин</surname><given-names>И В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff5"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gafarova</surname><given-names>A V</given-names></name><name xml:lang="ru"><surname>Гафарова</surname><given-names>А В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff5"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">«НИИ терапии и профилактической медицины» СО РАМН, Новосибирск, Россия</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="ru">Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний СО РАМН, Новосибирск, Томск, Тюмень, Россия</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="ru">ФГБУ «НИИ терапии и профилактической медицины» СО РАМН, Новосибирск, Россия</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff id="aff4"><institution>Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний СО РАМН, Новосибирск, Томск, Тюмень, Россия</institution></aff><aff id="aff5"><institution>ФГБУ «НИИ терапии и профилактической медицины» СО РАМН, Новосибирск, Россия</institution></aff><pub-date date-type="pub" iso-8601-date="2015-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2015</year></pub-date><volume>87</volume><issue>3</issue><issue-title xml:lang="en">VOL 87, NO3 ()</issue-title><issue-title xml:lang="ru">ТОМ 87, №3 (2015)</issue-title><fpage>71</fpage><lpage>76</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31723">https://ter-arkhiv.ru/0040-3660/article/view/31723</self-uri><abstract xml:lang="en"><p>Aim. To determine the impact of workplace stress on the hazard ratio (HR) of myocardial infarction (MI) and stroke in an open female population aged 25—64 years in Russia/Siberia (Novosibirsk) for 16 years. Subjects and methods. A random representative sample of 25-64-year-old women (n=870) residing in a Novosibirsk district was surveyed within the framework of the WHO «MONICA-psychological» program. Workplace stress was investigated using the Karasek scale; an attitude towards work and health prophylactic examinations was studied applying the Health Awareness and Attitude questionnaire of the WHO «MONICA-psychological» program. For 16 years (1994 to 2010), a cohort of all new cases of MI and stroke was examined employing the WHO «Acute MI Registry» program and all possible medical records. The Cox regression model was used to determine HR for MI and stroke in the open female population aged 25—64 years for 16 years. Results. The prevalence of high-level stress in the open female population aged 25—64 years was 31.6%. The high level of job stress was associated with a high responsibility, impossibility to have a rest at the end of a working day, frequent professional dissatisfaction, and a reduced work capacity. During 16 years, the women having high-level job stress showed a 3.22- and 1.96-fold increases in the HR of MI (p&lt;0.05) and stroke (p&lt;0.05), respectively. The incidence of MI and stroke was higher in married women expressing job stress as managers or manual laborers and having high and low educational attainment. Conclusion. The prevalence of high-level workplace stress was substantial in the open population of 25—64-year-old women in Russia/Siberia (Novosibirsk). The stress-related HR of MI and stroke was 3—2 times higher than in those without high-level stress. The HR of MI and stroke is affected by a social gradient.</p></abstract><trans-abstract xml:lang="ru"><p>Цель исследования. Определить влияние стресса на рабочем месте на отношение риска (ОР; HR) развития инфаркта миокарда (ИМ) и инсульта в открытой популяции женщин 25—64 лет в течение 16 лет в России/Сибири (Новосибирск). Материалы и методы. В рамках программы ВОЗ «MONICA-психосоциальная» в 1994 г. обследована случайная репрезентативная выборка 870 женщин в возрасте 25—64 лет — жительниц одного из района Новосибирска. Стресс на рабочем месте изучен с использованием шкалы Карасека; отношение к работе и профилактическим проверкам своего здоровья исследовано при помощи шкалы «Знание и отношение к своему здоровью» программы ВОЗ «MONICA-психосоциальная». В течение 16 лет (с 1994 по 2010 г.) в когорте исследовали все впервые возникшие случаи ИМ и инсульта с использованием программы ВОЗ «Регистр острого ИМ», всей возможной медицинской документации. Регрессионную модель Кокса использовали для определения ОР развития ИМ и инсульта в открытой популяции женщин 25—64 лет в течение 16 лет. Результаты. Распространенность высокого уровня стресса в открытой популяции женщин 25—64 лет составила 31,6%. Высокий уровень стресса на работе ассоциировался с высокой ответственностью, невозможностью отдохнуть в конце рабочего дня, частой профессиональной неудовлетворенностью и снижением трудоспособности. В течение 16 лет ОР развития ИМ был в 3,22 раза (p&lt;0,05), инсульта — в 1,96 раза (p&lt;0,05) выше у женщин с высоким уровнем стресса на работе. Частота возникновения ИМ и инсульта выше у замужних женщин, испытывающих стресс на работе, в категории «руководитель» и «физический труд» с высоким и низким уровнем образования. Заключение. Распространенность высокого уровня стресса на рабочем месте в открытой популяции России/Сибири (Новосибирск) у женщин 25—64 лет значительна. При нем ОР развития ИМ, инсульта в 3—2 раза выше, чем без высокого уровня стресса. На ОР развития ИМ, инсульта влияет социальный градиент.</p></trans-abstract><kwd-group xml:lang="en"><kwd>workplace stress</kwd><kwd>hazard ratio</kwd><kwd>myocardial infarction</kwd><kwd>stroke</kwd><kwd>social gradient</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>стресс на рабочем месте</kwd><kwd>отношение риска</kwd><kwd>инфаркт миокарда</kwd><kwd>инсульт</kwd><kwd>социальный градиент</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Holmgren K., Dahlin-Ivanoff S., Bjrkelund C. et al. The prevalence of work-related stress, and its association with self-perceived health and sick-leave, in a population of employed Swedish women. BMC Public Health 2009; 9: 73.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Karasek R., Theorell T. Healthy Work: Stress, Productivity and the Reconstruction of Working Life. 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