Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya31698Editorial articleПередовая статьяResearch ArticleArterial hypertension: An expanding pathogenic continuum and therapeutic limitationsАртериальная гипертензия: расширяющийся патогенетический континуум и терапевтические ограниченияKharchenkoE PХарченкоЕ ПФГБУН "Институт эволюционной физиологии и биохимии им. И.М. Сеченова" РАН, Санкт-Петербург, Россия15012015871VOL 87, NO1 ()ТОМ 87, №1 (2015)10010410042020Copyright ©; 2015, Consilium MedicumCopyright ©; 2015, ООО "Консилиум Медикум"2015Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/31698

The paper considers the role of the immune system, endoplasmic network stress, metabolic dysregulation, and epigenetic mechanisms in the pathogenesis of essential hypertension, as well as the limited possibilities of therapy with existing antihypertensive agents.

Аннотация. Рассматриваются роль иммунной системы, стресса эндоплазматической сети, метаболической дисрегуляции и эпигенетических механизмов в патогенезе эссенциальной артериальной гипертонии, а также ограниченные возможности терапии существующими антигипертензивными препаратами.

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