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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31632</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Full-dose combinations of antihypertensive drugs: What has changed in experts' guidelines?</article-title><trans-title-group xml:lang="ru"><trans-title>Полнодозовые комбинации антигипертензивных препаратов: что изменилось в рекомендациях экспертов?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fomin</surname><given-names>V V</given-names></name><name xml:lang="ru"><surname>Фомин</surname><given-names>В В</given-names></name></name-alternatives><email>fomin_vic@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Svistunov</surname><given-names>A A</given-names></name><name xml:lang="ru"><surname>Свистунов</surname><given-names>А А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО "Первый МГМУ им. И.М. Сеченова" Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2014</year></pub-date><volume>86</volume><issue>10</issue><issue-title xml:lang="en">VOL 86, NO10 (2014)</issue-title><issue-title xml:lang="ru">ТОМ 86, №10 (2014)</issue-title><fpage>124</fpage><lpage>127</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31632">https://ter-arkhiv.ru/0040-3660/article/view/31632</self-uri><abstract xml:lang="en"><p>The 2013 European Society of Hypertension guidelines, including treatment policy changes presupposing that one two-component combination of antihypertensive agents may be substituted for another and their full-dose combinations may be prescribed if monotherapy is ineffective, are discussed. A rationale is provided for the most effective two-component full-dose combinations of antihypertensive drugs.</p></abstract><trans-abstract xml:lang="ru"><p>Аннотация. Обсуждаются рекомендации Европейского общества по артериальной гипертонии версии 2013 г., в том числе изменения в тактике лечения, предполагающие возможность смены одной двухкомпонентной комбинации антигипертензивных препаратов другой и назначение полнодозовых комбинаций при неэффективности монотерапии. Представлено обоснование наиболее эффективных двухкомпонентных полнодозовых комбинаций антигипертензивных препаратов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>antihypertensive therapy</kwd><kwd>combination</kwd><kwd>guidelines</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>антигипертензивная терапия</kwd><kwd>комбинации</kwd><kwd>рекомендации</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>The ESH/ESC Task Force. 2013 ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013; 31 (7): 1281-1357.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Lindholm L.H., Carlberg B., Samuelsson O. Beta blockers in primary hypertension: do age and type of beta blocker matter? J Hypertens 2006; 24 (11): 2143-2145.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Dahlof B., Sever P., Poulter N.R. et al., ASCOT Investigators. 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