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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31615</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Thyroid dysfunction and the hemostatic system</article-title><trans-title-group xml:lang="ru"><trans-title>Нарушения функции щитовидной железы и система гемостаза</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Platonova</surname><given-names>N M</given-names></name><name xml:lang="ru"><surname>Платонова</surname><given-names>Н М</given-names></name></name-alternatives><email>doc-platonova@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sviridonova</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Свиридонова</surname><given-names>М А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Troshina</surname><given-names>E A</given-names></name><name xml:lang="ru"><surname>Трошина</surname><given-names>Е А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГБУ "Эндокринологический научный центр" Минздрава России, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2014</year></pub-date><volume>86</volume><issue>10</issue><issue-title xml:lang="en">VOL 86, NO10 (2014)</issue-title><issue-title xml:lang="ru">ТОМ 86, №10 (2014)</issue-title><fpage>92</fpage><lpage>96</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31615">https://ter-arkhiv.ru/0040-3660/article/view/31615</self-uri><abstract xml:lang="en"><p>Whether there is a link between thyroid dysfunction and different impairments in the hemostatic system is discussed. The level of thyroid hormones is an essential factor that influences the coagulation system. Thyroid dysfunction affects the balance between coagulation and fibrinolysis, by increasing the risk of thrombosis and hemorrhage in hyperthyroidism. However, there is no consensus of opinion regarding the mechanisms of the described hemostatic changes in the literature.</p></abstract><trans-abstract xml:lang="ru"><p>Аннотация. Обсуждается вопрос взаимосвязи дисфункции щитовидной железы (ЩЖ) и различных нарушений в системе гемостаза. Уровень тиреоидных гормонов - существенный фактор, влияющий на свертывающую систему крови. Дисфункция ЩЖ влияет на баланс между коагуляцией и фибринолизом, увеличивая риск развития тромбозов при гипертиреозе и кровотечений при гипотиреозе. Однако в литературе нет единого мнения о механизмах описанных гемостатических изменений.</p></trans-abstract><kwd-group xml:lang="en"><kwd>thyroid</kwd><kwd>coagulation</kwd><kwd>fibrinolysis</kwd><kwd>hypothyroidism</kwd><kwd>hyperthyroidism</kwd><kwd>thrombosis</kwd><kwd>bleeding</kwd><kwd>hemostatic system</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>щитовидная железа</kwd><kwd>коагуляция</kwd><kwd>фибринолиз</kwd><kwd>гипотиреоз</kwd><kwd>гипертиреоз</kwd><kwd>тромбоз</kwd><kwd>кровотечение</kwd><kwd>система гемостаза</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Shih C.H., Chen S.L., Yen C.C. et al. Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen and coagulation proteins. Endocrinology 2004; 145: 2804-2814.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Franklyn J.A., Sheppard M.C., Maisonneuve P. Thyroid function and mortality in patients treated for hyperthyroidism. JAMA 2005; 294 (1): 71-80.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Metso S., Jaatinen P., Huhtala H. et al. Increased cardiovascular and cancer mortality after radioiodine treatment for hyperthyroidism. J Clin Endocrin Metab 2007; 92 (6): 2190-2196.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Nyirenda M.J., Clark D.N., Finlayson A.R. et al. Thyroid disease and increased cardiovascular risk. Thyroid 2005; 15 (7): 718-725.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Squizzato A., Gerdes V.E.A, Brandjes D.P.M. et al. Thyroid diseases and cerebrovascular disease. Stroke 2005; 36: 2302-2310.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Erem C. Blood coagulation, fibrinolytic activity and lipid profile in subclinical thyroid disease: subclinical hyperthyroidism increases plasma factor X activity. Clin Endocrinol 2006; 64: 323-329.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Klein I., Ojamaa K. Thyroid hormone and the cardiovascular system. New Engl J Med 2001; 344: 501-509.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Физиология человека. Под ред. В.М. Покровского, В.Г. Коротько. Т. 1. М: Медицина 1997: 313-325.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Торшин В.И., Власова В.М., Агаджанян Н.А. Основы физиологии человека. В учебнике для студентов вузов, обучающихся по медицинским и биологическим специальностям, 2-е изд., исправл. М: РУДН 2001: 154-165</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Bennett N.B., Ogston C.M., McAndrew G.M. The thyroid and fibrinolysis. Br Med J 1967; 4: 147-148.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Squizzato A., Gerdes V.E., Brandjes D.P. et al. Thyroid diseases and cerebrovascular disease. Stroke 2005; 36 (10): 2302-2310.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Marongiu F., Conti M., Murtas M.L. et al. Anticardiolipin antibodies in Graves' disease: relationship with thrombin activity in vivo. Thromb Res 1991; 64 (6): 745-749.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Lodha A., Haran M., Frankel R., Shani J. Thyrotoxicosis causing arterial and venous thrombosis. Am J Med Sci 2009; 338 (5): 428-437.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Erem C., Ersoz H.Ö., Karti S.S. et al. Blood coagulation and fibrinolysis in patients with hyperthyroidism. J Endocrinol Invest 2002; 25 (4): 345-350.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lippi G., Franchini M., Targher G. et al. Hyperthyroidism is associated with shortened APTT and increased fibrinogen values in a general population of unselected outpatients. J Thromb Thrombolys 2009; 28 (3): 362-365.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Burggraaf J., Lalezari S., Emeis J.J. et al. Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazole. Thyroid 2001; 11 (2): 153-160.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Soma M., Maeda Y., Matsuura R. et al. Study of serum thrombomodulin (TM) levels in patients with hyper- or hypothyroidism [in Japanese]. Rinsho Byori 1997; 45 (1): 77-81.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Franchini M. Hemostasis and thyroid diseases revisited. J Endocrinol Invest 2004; 27 (9): 886-892.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Rogers J.S., Shane S.R. Factor VIII activity in normal volunteers receiving oral thyroid hormone. J Lab Clin Med 1983; 102: 444-449.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Horne M.K. 3rd, Singh K.K., Rosenfeld K.G. et al. Is thyroid hormone suppression therapy prothrombotic. J Clin Endocrinol Metab 2004; 9: 4469-4473.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Demir T., Akinci B., Comlekci A. et al. 2008 Levothyroxine suppression treatment for benign thyroid nodules alters coagulation. Clin Endocrinol (Oxf) 2009; 71 (3): 446-450.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Negrev N.N., Radev R.Z., Velikova M.S., Anogeianaki A. Effects of the hormones of the thyroid axis on the vitamin K-dependent plasma factors of blood coagulation (II, VII, IX and X). Int J Immunopathol Pharmacol 2008; 21: 221-226.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Kellett H.A., Sawers J.S., Boulton F.E. et al. Problems of anticoagulation with warfarin in hyperthyroidism. Q J Med 1986; 58: 43-51.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Sievert R., Goldstein M.L., Surks M.I. Graves' disease and autoimmune factor VIII deficiency. Thyroid 1996; 6: 245-247.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Marongiu F., Cauli C., Mameli G. et al. Apathetic Graves' disease and acquired hemophilia due to factor VIIIc antibody. J Endocrinol Invest 2002; 25: 246-249.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Dorr M., Robinson D.M., Wallaschofski H. et al. Low serum thyrotropin is associated with high plasma fibrinogen. J Clin Endocrinol Metab 2006; 91: 530-534.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Coban E., Aydemir M., Yazicioglu G., Ozdogan M. Endothelial dysfunction in subjects with subclinical hyperthyroidism. J Endocrinol Invest 2006; 29: 197-200.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Stuijver D.J., van Zaane B., Romualdi E. et al. The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis. Thromb Haemost 2012; 108 (6): 1077-1088.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Hofbauer L.C., Heufelder A.E. Coagulation disorders in thyroid diseases. Eur J Endocrinol 1997; 136: 1-7.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Marqusee E., Mandel S.J. The blood in hypothyroidism, in Werner &amp; Ingbar's The Thyroid: A Fundamental and Clinical Text, 8th edn., ed. by L.E. Braverman, R.D. Utiger. Lippincott Williams &amp; Wilkins, Philadelphia 2000: 800-803.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Egeberg B.O. Influence of thyroid function on blood clotting system. Scand J Clin Lab Invest 1963; 15: 1-7.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Simone J.V., Abildgaard C.F., Schulman I. Blood coagulation in thyroid dysfunction. N Engl J Med 1965; 273: 1057-1061.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Hume R. Fibrinolytic activity and thyroid function. Br Med J 1965; 1: 686-688.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Rennie J.A., Bewsher P.D., Murchison L.E., Ogston D. Coagulation and fibrinolysis in thyroid disease. Acta Haematol 1978; 59: 171-177.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Gullu S., Sav H., Kamel N. Effects of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism. Eur J Endocrinol 2005; 152: 355-361.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Arnaout M.A., Awidi A.S., el-Najdawi A.M. et al. Arginine-vasopressin and endothelium-associated proteins in thyroid disease. Acta Endocrinol (Copenh) 1992; 126: 399-403.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Marongiu F., Biondi G., Conti M. et al. Is a hypercoagulable state present in hypothyroidism. Thromb Haemost 1992; 67: 729.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Chadarevian R., Bruckert E., Ankri A. et al. Relationship between thyroid hormones and plasma D-dimer levels. Thromb Haemost 1998; 79: 99-103.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Chadarevian R., Bruckert E., Giral P., Turpin G. Relationship between thyroid hormones and fibrinogen levels. Blood Coagul Fibrinolysis 1999; 10: 481-486.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Yong P.H., Junit S.M., Harun F., Hashim O.H. Patients with congenital hypothyroidism demonstrate different altered expression of plasma fibrinogen and haptoglobin polypeptide chains. Clin Biochem 2006; 39: 126-132.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Erem C., Kavgaci H., Ersöz H.O. et al. Blood coagulation and fibrinolytic activity in hypothyroidism. Int J Clin Pract 2003; 57: 78-81.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Akinci B., Comlekci A., Yener S. et al. Thrombin activatable fibrinolysis inhibitor antigen levels are inversely correlated with plasminogen activator inhibitor-1 antigen levels in hyperthyroid patients. Endocr J 2007; 54: 593-599.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Verkleij C.J., Stuijver D.J., van Zaane B. et al. Thrombin-activatable fibrinolysis inhibitor in hypothyroidism and hyperthyroxinaemia. Thromb Haemost 2013; 109 (2): 214-220.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Erem C., Ucuncu O., Yilmaz M. et al. Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. Endocrine 2009; 35 (1): 75-80.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Muller B., Tsakiris D.A., Roth C.B. et al. Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease. Eur J Clin Invest 2001; 31: 131-137.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Jayaprasad N., Francis J. Atrial fibrillation and hyperthyroidism. Indian Pacing Electrophysiol J 2005; 5: 305-311.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Bar-Sela S., Ehrenfeld M., Eliakim M. Arterial embolism in thyrotoxicosis with atrial fibrillation. Arch Intern Med 1981; 141: 1191-1192.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Chadarevian R., Bruckert E., Leenhardt L. et al. Components of the fibrinolytic system are differently altered in moderate and severe hypothyroidism. J Clin Endocrinol Metab 2001; 86: 732-737.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Guldiken S., Demir M., Turgut B. et al. Global fibrinolytic capacity in patients with subclinical hypothyroidism. Endocr J 2005; 52: 363-367.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Jorde R., Figenschau Y., Hansen J.B. Haemostatic function in subjects with mild subclinical hypothyroidism. The Tromso study. Thromb Haemost 2006; 95: 750-751.</mixed-citation></ref></ref-list></back></article>
