Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya31561Research ArticleClinical efficacy of functional foods in patients with gastrointestinal disordersShcherbakovP Lpol_ochka@rambler.ruShcherbakovaM Iu-ParfenovA I-RuchkinaI N-Kuz'minaT N-15082014868626910042020Copyright © 2014, Consilium Medicum2014AIM. To identify micronutrient deficiencies in patients with functional bowel diseases (FBD) and to reveal their correction with functional foods and probiotics. MATERIALS AND METHODS. The health status was evaluated in 90 patients aged 18 to 67 years with FBD. All the patients were randomized into 3 groups according to the treatment regimen. Group 1 took Amaltea goat's milk 200 ml/day during basic therapy; Group 2 received multispecies and multistrain RioFlora Balance probiotics in addition to the above components; Group 3 (a control group) had traditional basic dietary therapy. All the groups continued their treatment for 14 days. RESULTS. The performed examinations have demonstrated that diet-based treatment fortified with goat's milk and multispecies probiotics makes it possible to more promptly achieve remission and to level off clinical manifestations than in the control group. The patients using multispecies probiotics versus the control group showed a reduction in fat-soluble vitamin deficiencies and a considerable improvement in quality of life. CONCLUSION. FBD lacks a specific clinical picture and may be masked as lactase deficiency, which commonly leads to noticeable limitations in patients' diet and favors the development of vitamin deficiency. Of particular concern is the development of vitamin D deficiency in young patients, which may result in the early development of osteoporosis in the future. To specify the composition of enzymes in the patients gives grounds to refuse restricted diets, and the dietary addition of functional foods (goat's milk fortified with vitamins and minerals), particularly in combination with multistrain probiotics, produces a pronounced clinical effect and eliminates fat-soluble vitamin deficiencies.microbiocenosisdysbacteriosisvitaminsintestinal microflorafunctional foodsmicronutrientsprobioticsмикробиоценоздисбактериозвитаминымикрофлора кишечникафункциональное питаниемикронутриентыпробиотики[Мечников И.И. Этюды оптимизма. Париж 13/26 мая 1907; 328.][Turnbaugh P.J., Ley R.E., Hamady M. et al. The human microbiome project. Nature 2007; 449 (7164): 804-810.][Бондаренко В.М., Боев Б.В., Лыкова Е.А., Воробьев А.А. Дисбактериозы желудочно-кишечного тракта. Рос журн гастроэнтерол, гепатол, колопроктол 1998; 1: 66-70.][Шендеров Б.А. Нормальная микрофлора и ее роль в поддержании здоровья человека. Рос журн гастроэнтерол, гепатол, колопроктол 1998; 1: 61-65.][Хавкин А.И. Микробиоценоз кишечника и иммунитет. РМЖ 2003; 3: 122-126.][Rolfe R.D. Interactions among microorganisms of the indigenous intestinal flora and their influence on the host. Rev Infect Dis 1984; 6: S73-79.][Воробьев А.А., Несвижский Ю.В., Липницкий Е.М. и др. Исследование пристеночной микрофлоры желудочно-кишечного тракта у человека в норме и при патологии. Вестн РАМН 2004; 2: 43-47.][Paiva S.A.R., Sepe T.E., Booth S.L. et al. Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. Am J Clin Nutr 1998; 68: 699-704.][Gill H.S. Stimulation of the immune system by lactic cultures. Int Dairy J 1998; 8: 535-544.][Nissle A. Uber die Grundlagen einer neuen ursachlichen Bekampfung der pathologishen Darmflora. Dtsch Med Wschr 1916; Dl. 42: 1181-1184.][Куваева И.Б. Обмен веществ организма и кишечная микрофлора. М: Медицина 1976; 247.][Куваева И.Б., Ладодо К.С. Микроэкологические и иммунные нарушения у детей. М 1991; 240.][Vergin F. Anti- und Probiotika. Hippokrates 1954; 25: 16-119.][Спиричев В.Б., Шатнюк Л.Н., Позняковский В.М. Обогащение пищевых продуктов витаминами и минеральными веществами. 2-е изд., Новосибирск: Сиб. унив. изд-во 2005; 548.][Морозкина Т.С., Мойсеенок А.Г. Витамины. Минск: Асар 2002; 58-63.][Olson J.A. Benefits and liabilities of vitamin А and carotenoids. J Nutr 1996; 126 (4): 1208-1212.][Semba R.D. On the "discovery" of vitamin A. Ann Nutr Metabol 2012; 61: 192-198.][Ball G.F.M. Vitamins. Their Role in the Human Body. Blackwell Science 2004; 432.][Holick M.F. Vitamin D deficiency. N Engl J Med 2007; 357 (3): 266-281.][Brigelius-Flohe R., Traber M.G. Vitamin E: function and metabolism. FASEB J 1999; 13 (9): 1007-1024.][Nikfar S., Rahimi R., Rahimi F. et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Dis Colon Rectum 2008; 51 (12): 1775-1780.][Hoveyda N., Heneghan C., Mahtani K.R. et al. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol 2009 16; 9: 15.][Kaizu H., Sasaki M., Nakajima H., Suzuki Y. Effect of antioxidative lactic acid bacteria on rats fed a diet deficient in vitamin E. J Dairy Sci 1993; 76 (9): 2493-2499.][Jones M.L., Martoni C.J., Prakash S. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab 2013; 98 (7): 2944-2951.][Roager H.M., Sulek K., Skov K. et al. Lactobacillus acidophilus NCFM affects vitamin E acetate metabolism and intestinal bile acid signature in monocolonized mice. Gut Microbes 2014; 5 (3) [Epub ahead of print].][Rambaud J.-C., Buts J.-P., Corthier G., Flourié B. Gut Microflora: Digestive Physiology and Pathology (Hardback). Paris: John Libbey eurotext 2006; 247.]