Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya31558Editorial articleПередовая статьяResearch ArticleMyeloid sarcoma of the small bowel with inversion of chromosome 16: a description of 3 clinical casesМиелоидная саркома тонкой кишки с инверсией 16-й хромосомы: описание 3 клинических случаевGavrilinaO AГаврилинаО Аdr.gavrilina@mail.ruBariakhE AБаряхЕ Аebaryakh@gmail.comParovichnikovaE NПаровичниковаЕ Нelenap@blood.ruTroitskaiaV VТроицкаяВ Вverat@blood.ruZvonkovE EЗвонковЕ Еdr.zvonkov@gmail.comKravchenkoS KКравченкоС Кkrav@blood.ruSinitsynaM NСиницынаМ Нmsini@mail.ruObukhovaT NОбуховаТ Нobuhova@blood.ruGitisM KГитисМ Кmgitis@gmail.comSavchenkoV GСавченкоВ Гsvg@blood.ruФГБУ "Гематологический научный цент" Минздрава России, Москва15072014867VOL 86, NO7 ()ТОМ 86, №7 (2014)859210042020Copyright ©; 2014, Consilium MedicumCopyright ©; 2014, ООО "Консилиум Медикум"2014Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/31558

Myeloid sarcoma (MS) is a rare malignant solid tumor presented with myeloid blast cells showing varying degrees of maturation. MS may have an extramedullary site, precede, or develop simultaneously with the clinical manifestations of acute myeloid leukemia (AML); it may also occur as an AML relapse. Besides AML, MS may be a manifestation of chronic myeloid leukemia or other chronic myeloproliferative diseases. Due to the fact that this disease is rare, the bulk of the literature on MS is presented with single descriptions of retrospective studies and clinical cases. The paper describes 3 cases of MS with inversion of chromosome 16 and small bowel lesion.

Аннотация. Миелоидная саркома (МС) - редкая злокачественная солидная опухоль, представленная бластными клетками миелоидного происхождения различной степени созревания. МС может иметь любую экстрамедуллярную локализацию, предшествовать или развиваться одновременно с клиническими проявлениями острого миелоидного лейкоза (ОМЛ), она также может возникать как рецидив ОМЛ. Кроме ОМЛ миелоидная саркома может быть проявлением хронического миелоидного лейкоза или других хронических миелопролиферативных заболеваний. Из-за редкости данного заболевания большая часть литературы, связанная с МС, представлена единичными описаниями ретроспективных исследований и клинических случаев. Представляем описание 3 случаев МС с инверсией 16-й хромосомы и поражением тонкой кишки.

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