Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya31529Review ArticleSubclinical interstitial lung disease associated with rheumatoid arthritisBestaevD Vdavidbestaev@rambler.ru1505201486510610810042020Copyright © 2014, Consilium Medicum2014Interstitial lung disease (ILD) in rheumatoid arthritis (RA) is its extra-articular manifestation. At the same time, ILD considerably worsens the prognosis of the disease. Mortality rates for interstitial pulmonary fibrosis are 6% of all-cause mortality in RA patients. ILD can be identified by clinical examination only in 2-6% of cases, by plain chest X-ray in 1-6%, and by high-resolution computed tomography in 50-60%. The paper deals with subclinical ILD and discusses the state-of-the-art of investigations in this area.rheumatoid arthritissubclinical courseinterstitial lung diseasehigh-resolution computed tomographyexternal respiratory functionревматоидный артритсубклиническое течениеинтерстициальное заболевание легкихкомпьютерная томография высокого разрешенияфункция внешнего дыхания[Насонова В.А., Насонов Е.Л. Рациональная фармакотерапия ревматических заболеваний: Руководство для практикующих врачей. М: Литтерра 2003; 86.][Kim E.J., Elicker B.M., Maldonado F. et al. Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease. Eur Respir J 2010; 35 (6): 1322-1328.][Kim E.J., Collard H.R., King T.E. Jr. Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern. Chest 2009; 136 (5): 1397-1405.][Ascherman D.P. Interstitial lung disease in rheumatoid arthritis. Curr Rheumatol Reports 2010; 12 (5): 363-369.][Bongartz T., Nannini C., Medina-Velasquez Y.F. et al. Incidence and mortality of interstitial lung disease in rheumatoid arthritis - a population-based study. Arthritis Rheum 2010; 62 (6): 1583-1591.][Sawada T., Inokuma S., Sato T. et al. Leflunomide-induced interstitial lung disease: prevalence and risk factors in Japanese patients with rheumatoid arthritis. Rheumatology 2009; 48 (9): 1069-1072.][Picchianti Diamanti A., Germano V., Bizzi E. et al. Interstitial lung disease in rheumatoid arthritis in the era of biologics. Pulmon Med 2011; 2011: 931342.][Gochuico B.R., Avila N.A., Chow C.K. et al. Progressive preclinical interstitial lung disease in rheumatoid arthritis. Arch Intern Med 2008; 168 (2): 159-166.][Juan Chen, Yong Hong Shi, XiaoPing Wang et al. Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease. Clin Dev Immunol 2013; 2013: 406927.][Arnett F.C., Edworthy S.M., Bloch D.A. et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31 (3): 315-324.][ATS/ERS task force. Standardization of spirometry: standardization of lung function testing, 2005 upd. Eur Resp J 2005; 26: 319-338.][Насонов Е.Л., Каратаев Д.Е., Балабанова Р.М. Ревматоидный артрит. В кн.: Насонова В.А., Насонов Е.Л. Ревматология. Национальное руководство. М: ГЭОТАР-Медиа 2008: 290-331.][Liote H. Pulmonary manifestation of rheumatoid arthritis. Revue des Maladies Respiratoires 2008; 25 (8): 973-988.][Biederer J., Schnabel A., Muhle C. et al. Correlation between HRCT findings, pulmonary function tests and bronchoalveolar lavage cytology in interstitial lung disease associated with rheumatoid arthritis. Eur Radiol 2004; 14 (2): 272-280.][Hamblin M.J., Horton M.R. Rheumatoid arthritis-associated interstitial lung disease: diagnostic dilemma. Pulmon Med 2011; 2011: ID 872120.]