Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya31475Review ArticlePromising immunonutrients in general medical practiceSheviakovM Ashevyakov@inbox.ruBuryginaE V-150220148629610110042020Copyright © 2014, Consilium Medicum2014The review gives data on prospects for using agents based on probiotics and trace elements for immunomodulation. It presents information on that a Lactobacillus casei rhamnosus 35-based probiotic is able to reduce the incidence and severity of viral and bacterial infections. The potential of zinc and selenium as immunotropic agents is shown.immunomodulationprobioticzincseleniumиммуномодуляцияпробиотикцинкселен[Хаитов Р.М., Ильина Н.И. Аллергология и иммунология. Национальное руководство. М: ГЭОТАР 2009; 487.][Ткаченко Е.И., Успенский Ю.П. Питание, микробиоценоз и интеллект человека. СПб: СпецЛит 2006; 590.][Тутельян В.А. Спиричев В.Б., Суханов Б.П., Кудашева В.А. Микронутриенты в питании здорового и больного человека. М: Колос 2002; 423.][Gut microflora. Digestive physiology and pathology. Rambaud J.-C., Buts J.-P. (eds). Paris: John libbey Eurotext 2006: 247.][ОСТ 91500. 11. 004-2003 (приложение). Протокол ведения больных. Дисбактериоз кишечника. Утвержден приказом Минздрава РФ от 9 июня 2003. №231; 82.][Пилипенко В.И. Пробиотики как сигнальные молекулы: Saccharomyces boulardii. Клин гастроэнтерол и гепатол 2008; 6: 456-462.][Sokol H., Seksik P., Rigottier-Gois L. et al. Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis 2006; 12: 106-111.][Balfuor R. Microbial influences in inflammatory bowel diseases. Gasroenterology 2008; 134: 577-594.][Salminen M.K. Biotherapeutic lactobacillus are the cause of bacteriaemiа in immunodeficiency patients. Clin Inf Dis 2006; 42: 35-44.][De Champs C., Maroncl N., Balestrino D. Persistence of colonization of intestinal mucosa by a probiotic strain, Lactobacillus casei subsp. Rhamnosus Lcr35 after oral consumption. J Clin Microbiol 2003; 41 (3): 1270-1273.][Moreau M.C., Gaboriau-Routhiau V. The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice. Res Immunol 1996; 147 (1): 49-59.][Forestier C., De Champs C., Vatoux C. et al. Probiotic activities of lactobacillus casei rhamnosus: in vitro adherence to intestinal cells and antimicrobial properties. Res Microbiol 2001; 152: 167-173.][Sudo N., Sawamura S., Tanaka K. et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997; 159 (4):1739-1745.][Coudeyras S., Marchandid H., Fajon C. et al. Taxonomic and strain-specific identification of the probiotic strain lactobacillus rhamnosus 35 within the lactobacillus casei group. Appl Environ Microbiol 2008; 74 (9): 2679-2689.][Evrard B., Coudeyras S., Dosgilbert A. et al. Dose-Depended Immunomodulation of human dendritic cells by the probiotic lactobacillus rhamnosus Lcr35. PLos One 2011; 6 (4): e18735.][Guarner F., Casellas F., Borruel N. Role of microecology in chronic inflammatory bowel diseases. Eur J Clin Nutr 2002; 56 (Suppl 4): 34-38.][Fang H.W., Fang S.B., Chiang Chiau J.S. et al. Inhibitory effects of Lactobacillus casei rhamnosus on Salmonella lipopolysaccharide-induced inflammation and epithelial barrier dysfunction in a co-culture model using Caco-2/peripheral blood mononuclear cells. J Med Microbiol 2010; 59 (Pt 5): 573-579.][Lin J.S., Chiu Y.H., Lin N.T. et al. Different effects of probiotic species|strains on infections in preschool children: a double-blind, randomized, controlled study. Vaccine 2009; 27: 1073-1079.][Nivoliez A., Camares O., Paquet-Gachinat M. et al. Influence of manufacturing processes on in vitro properties of the probiotic strain Lactobacillus rhamnosus Lcr35. J Biotechnol 2012; 160 (3-4): 236-241.][Громова О.А., Ребров В.Г., Федосеенко М.Г. Клиническая элементология. М: ГЭОТАР-Мед 2007; 632.][Prasad A.S. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp Geront 2008; 43: 370-377.][Rayman M.P. The importance of selenium to human health. Lancet 2000; 356 (9233): 943-944.][Костинов М.П. Иммунокоррекция в педиатрии. Практическое руководство для врачей. М: Медицина для всех 2001: 15.]