Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya31451Research ArticleWhipple's disease in a patient with infantile cerebral palsy and hepatitis B virus cirrhosisKrumsL Mgastroenter@ramler.ruSabel'nikovaE A-GolovanovaE V-ChikunovaB Z-ParfenovA I-15022014862697110042020Copyright © 2014, Consilium Medicum2014The paper describes a patient who has developed Whipple's disease in the presence of infantile cerebral palsy and hepatitis B virus cirrhosis. After 5-year treatment with co-trimoxazole (480 mg b.i.d.), the clinical manifestations subsided and PAS-positive macrophages were no longer detectable in the small intestinal mucosal biopsy specimens. Subsequent worsening of the patient's condition was associated with the progression of liver cirrhosis.Whipple's diseaseinfantile cerebral palsyliver cirrhosisболезнь Уиппладетский церебральный параличцирроз печени[Dulty F., Altwegg M. Whipple Disease and Tropheryma whippelii. J Clin Microbiol Rev 2001; 14: 561-583.][Логинов А.С., Парфенов А.И., Полева Н.И. Болезнь Уиппла: результаты длительного наблюдения. Тер арх 1998; 7: 35-41.][Маев И.В., Жиляев Е.В., Дичева Д.Т. и др. Болезнь Уиппла. РЖГГ 2008; 18: 80-85.][Lange U., Teichman J. Whipple arthritis diagnosis by molecular analysis of synovial fluid - current status of diagnosis and therapy. J Rheumatol 2003; 42: 473-480.][Гриценко И.И., Степанов Ю.М., Щербинина М.Б. Клинический разбор случая болезни Уиппла. Сучасна гастроентерол 2003; 12: 57-61.][Marth T., Raoult D. Whipple's disease. Lancet 2003; 361: 239-246.]