Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya31413Editorial articleПередовая статьяReview ArticleRole of the endothelin receptor antagonist bosentan in the treatment of patients with pulmonary hypertensionРоль антагониста эндотелиновых рецепторов бозентана в лечении больных легочной артериальной гипертензиейTsarevaN AЦареваН Аn_tsareva@mail.ruНИИ пульмонологии ФМБА России, Москва151220138512VOL 85, NO12 (2013)ТОМ 85, №12 (2013)12713610042020Copyright ©; 2013, Consilium MedicumCopyright ©; 2013, ООО "Консилиум Медикум"2013Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/31413

The paper reviews current views of the problem of pulmonary hypertension. It shows the classification of pulmonary hypertension and considers the general issues of its pathogenesis, morphological changes, clinical picture, and main approaches to treating patients with pathology. Particular emphasis is placed on the review of clinical trials of the class of endothelin receptor antagonists.

Аннотация. В статье приводится обзор современных взглядов на проблему легочной гипертензии. Представлена классификация легочной гипертензии, рассматриваются общие вопросы патогенеза, морфологических изменений, клинической картины, диагностики, а также основных подходов к лечению больных с данной патологией. Особое внимание отводится обзору клинических исследований, посвященных классу антагонистов эндотелиновых рецепторов.

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