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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31272</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Ghrelin and its role in health and disease</article-title><trans-title-group xml:lang="ru"><trans-title>Грелин и его роль в норме и патологии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tereshchenko</surname><given-names>I V</given-names></name><name xml:lang="ru"><surname>Терещенко</surname><given-names>И В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kaiushev</surname><given-names>P E</given-names></name><name xml:lang="ru"><surname>Каюшев</surname><given-names>П Е</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Пермская государственная медицинская академия им. акад. Е.А. Вагнера Минздрава РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2013</year></pub-date><volume>85</volume><issue>4</issue><issue-title xml:lang="en">VOL 85, NO4 ()</issue-title><issue-title xml:lang="ru">ТОМ 85, №4 (2013)</issue-title><fpage>98</fpage><lpage>101</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31272">https://ter-arkhiv.ru/0040-3660/article/view/31272</self-uri><abstract xml:lang="en"><p>The paper provides a review of the present-day literature on the role of the hormone ghrelin discovered in 1999.</p></abstract><trans-abstract xml:lang="ru"><p>Аннотация. Представлен обзор современной литературы о роли гормона грелина, открытого в 1999 г.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ghrelin</kwd><kwd>obesity</kwd><kwd>appetite regulation</kwd><kwd>cholelithiasis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>грелин</kwd><kwd>ожирение</kwd><kwd>регуляция аппетита</kwd><kwd>желчно-каменная болезнь</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kojima M., Hosoda H., Date Y. et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Mori K., Yoshimoto A., Takaya K. et al. Kidney produces a novel acylated peptide, ghrelin FEBS Lett 2000; 486 (3): 213-216.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Панков Ю.А. Революционные перемены в эндокринологии. Пробл эндокринол 2005; 6: 3-8.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Васюкова О.В., Витебская А.В. Грелин: биологическое значение и перспективы применения в эндокринологии. Пробл эндокринол 2006; 2: 3-7.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Date Y., Kojima M., Hosoda H. et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000; 141: 4255-4261.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Chiesa C., Osborn J.F., Pacifico L. et al. Circulation Ghrelin in patients undergoing elective cholecystectomy. Clin Chem 2005; 51 (7): 1258-1261.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Парфенов А.И. Грелин и пептид YY - регуляторы аппетита и количества потребляемой пищи. Перспективы лечения кахексии и ожирения. Тер арх 2005; 2: 92-94.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Wu J.T., Kral J.G. Ghrelin: integrative neuroendocrine peptide in health and disease. Ann Surg 2004; 239: 464-474.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Fuglsang J., Skjaebaek C., Espelund U. et al. Ghrelin and its relationship to growth hormones during normal pregnancy. Clin Endocrinol (Oxf) 2005; 62 (5): 554-559.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Tena-Sempere M. Roles of ghrelin and leptin in the control of reproductive function. Neuroendocrinol 2007; 86: 229-241.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Gualillo O., Caminos J., Blanco M. et al. Ghrelin, a novel placental-derived hormone. Casanueva Endocrinol 2001; 142 (2): 788-794.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Kheradmand А., Alirezaei M., Asadian P. et al. Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia 2009; 41 (6): 335-340.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Bennett N.R., Boyne M.S., Cooper R.S. et al. Impact of adiponectin and ghrelin on incident glucose intolerance and on weight change. Clin Endocrinol 2009; 70 (3): 408-414.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Meier U., Gressner A.M. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin and resistin. Clin Chem 2004; 50: 1511-1525.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Egido E.M., Rodriguez-Gallardo J., Silvestre R.A. et al. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol 2002; 146 (2): 241-244.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Dixit V.D., Schaffer E.M., Pale R.S. et al. Ghrelin inhibits leptin and activation-induced proinflammatory cytokine expression by human monocytes and T-cells. J Clin Inv 2004; 114: 57-66.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Murdolo G., Lucidi P., Di Loreto C. et al. Insulin is required for prandial ghrelin suppression in humans. Diabetes 2003; 52 (12): 2923-2927.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Mohlig M., Spranger J., Otto B. et al. Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest 2002; 25 (11): 3638.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Monteleone P., Bencivenga R., Longobardi N. et al. Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women. J Clin Endocrinol Metab 2003; 88 (11): 5510-5514.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Орлова Е.Г., Ширшев С.В. Регуляция лептином и грелином экспрессии мембранных молекул и апоптоза лимфоцитов человека при беременности. Пробл эндокринол 2010; 3: 26-30.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Chan J.L., Bullen J., Lee J.H. et al. Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects. J Clin Endocrinol Metab 2004; 89: 335-343.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Schofl C., Horn R., Schill T. et al. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2002; 87 (10): 4607-4610.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Espelund U., Hansen T.K., Hojlund K. et al. Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab 2005; 90: 741-746.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Whatmore A.J., Hall C.M., Jones J. et al. Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf) 2003; 59 (5): 649-654.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Wierup N., Yang S., McEvilly R.J. et al. Ghrelin is expressed in a Novel Endocrine Cell Type in developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells. J Hystoche Cytochem 2004; 52 (3): 301-310.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Mendes-Sanches N., Ponciano-Rodrigues G., Bermegjo-Martines L. et al. Low serum levels of ghrelin are assosiated with gallstone disease. World J Gastroenterol 2006; 12 (19): 3096-3100.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Nagaya N., Kojima M., Uematsu M. et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regul Integr Physiol 2001; 280 (5): 1483-1487.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Okumura E.L., Nagaya N., Enomoto M. et al. Vasodilatoiy effect of ghrelin, an endogenous peptide from the stomach. J Cardiovasc Pharmacol 2002; 39 (6): 779-783.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Hattori N., Saito. T., Yagyu T. et al. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T-cells, B-cells, and neutrophils. J Clin Endocrinol Metabol 2001; 86: 4284-4291.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Wasseem T., Duxbury M., Ito H. et al. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 2008; 143: 334-342.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>van der Lely A.J., Tschop M., Heiman M.L., Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004; 25 (3): 426-457.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Cummings D.E., Shannon M.H. Roles for ghrelin in the regulation of appetite and body weight. Arch Surg 2003; 138: 389-396.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Tschop M., Weyer C., Tataranni P.A. et al. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001; 50: 707-709.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Tschop M., Wawarta R., Riepl R.L. et al. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 2001; 24: 19-21.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Guo Z.F., Zheng X., Qin Y.W. et al. Circulating preprandial ghrelin to obestatin ratio is increased in human obesity. J Clin Endocrinol Metab 2007; 92 (5): 1875-1880.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Langenberg C., Bergstrom J., Laughlin C.A. et al. Ghrelin and the metabolic syndrome in older adalts. J. Clin. Endocrinol. Metab. 2005; 90: 6448-6453.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Вербовой А.Ф., Решетова О.Н. Грелин и гормонально-метаболические показатели у юношей с ожирением и избыточной массой тела. Пробл эндокринол 2009; 2: 23-26.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Kanumakala S., Greaves R., Pedreira С.C. et al. Fasting ghrelin levels are not elevated in children with hypothalamic obesity. J Clin Endocrinol Metab 2005; 90 (5): 2691-2695.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Pöykkö S.M. Ghrelin, metabolic risk factors and carotid artery athersclerosis. Acta Univ Ouluen 2005; 816: 91-93.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Pöykkö S.M., Kellokoski E., Hörkkö S. et al. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003; 52 (10): 2546-2553.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Otto B., Cuntz U., Fruehauf E. et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001; 145: 669-673.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Engstrom B.E., Burman P., Holdstock C., Karlsson F.A. Effects of growth hormone (GH) on ghrelin, leptin and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 2003; 88 (11): 5193-5198.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Korbonits M., Kojima M., Kangawa K., Grossman A.B. Presence of ghrelin in normal and adenomatous human pituitaiy. Endocrine 2001; 14 (1): 101-104.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Сetinkaya Z., Aydin S., Cerrahoglu Y.Z. et al. Changes in appetite hormone (ghrelin) levels of saliva and serum in acute appendicitis cases before and after operation. Appetite 2009; 52 (1): 104-107.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Каюшев П.Е., Терещенко И.В. Роль грелина при хирургическом стрессе. Онкология - ХХI век. Матер. VI (XV) Междунар. науч. конф. по онкологии. Пермь: Книжный формат 2011: 175-180.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Терещенко И.В., Каюшев П.Е. Секреция грелина у больных, оперированных по поводу желчно-каменной болезни. Хирургия 2011; 10: 39-42.</mixed-citation></ref></ref-list></back></article>
