Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya31237Editorial articleПередовая статьяReview ArticleSerotoninergic regulation of colonic motor functionСеротонинергическая регуляция моторной функции толстой кишкиLychkovaA ÉЛычковаА Эlychkova@mail.ruЦНИИ гастроэнтерологии Департамента здравоохранения Москвы15022013852VOL 85, NO2 ()ТОМ 85, №2 (2013)899210042020Copyright ©; 2013, Consilium MedicumCopyright ©; 2013, ООО "Консилиум Медикум"2013Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/31237

The review deals with the serotoninergic regulation of colonic motor function. Serotonin (HT), its receptors and transporter, the enzymes of synthesis and degradation, play an important role in the regulation of colonic motor activity. Activation of 5-НТ1, 5-НТ2В, 5-НТ3, and 5-НТ4 receptors leads to increased colonic motor function. The elevation of serotonin levels determines the higher sensitivity of the colonic wall in irritable bowel syndrome. Serotonin plays a pathogenetic role in the development of ulcerative colitis and colostasis.

Аннотация. Обзор посвящен серотонинергической регуляции моторной функции толстой кишки. В регуляции моторной активности толстой кишки важную роль играют серотонин (НТ), его рецепторы и транспортер, ферменты синтеза и разрушения. Активация рецепторов 5-НТ1, 5-НТ2В, 5-НТ3 и 5-НТ4 приводит к усилению моторной функции толстой кишки. Увеличение уровня серотонина определяет повышение висцеральной чувствительности стенки толстой кишки при синдроме раздраженного кишечника. Серотонин играет патогенетическую роль при развитии язвенного колита и колостаза.

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