<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31226</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Nonglycemic effects of dipeptidyl peptidase-4 inhibitors</article-title><trans-title-group xml:lang="ru"><trans-title>Негликемические эффекты ингибиторов дипептидилпептидазы-4</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ametov</surname><given-names>A S</given-names></name><name xml:lang="ru"><surname>Аметов</surname><given-names>А С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kamynina</surname><given-names>L L</given-names></name><name xml:lang="ru"><surname>Камынина</surname><given-names>Л Л</given-names></name></name-alternatives><email>petrology@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБОУ ДПО "Российская медицинская академия последипломного образования" Минздрава РФ, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2013</year></pub-date><volume>85</volume><issue>1</issue><issue-title xml:lang="en">VOL 85, NO1 ()</issue-title><issue-title xml:lang="ru">ТОМ 85, №1 (2013)</issue-title><fpage>98</fpage><lpage>102</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31226">https://ter-arkhiv.ru/0040-3660/article/view/31226</self-uri><abstract xml:lang="en"><p>The review considers the major nonglycemic effects of dipeptidyl peptidase-4 inhibitors commonly used in diabetological practice, by using as an example sitagliptin, the first and most investigated representative of this class.</p></abstract><trans-abstract xml:lang="ru"><p>Аннотация. В обзоре рассмотрены основные негликемические эффекты широко используемых в диабетологической практике ингибиторов дипептидилпептидазы-4 на примере ситаглиптина - первого и наиболее изученного представителя этого класса.</p></trans-abstract><kwd-group xml:lang="en"><kwd>type 2 diabetes mellitus</kwd><kwd>dipeptidyl peptidase-4 inhibitors</kwd><kwd>sitagliptin</kwd><kwd>nonglycemic effects</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сахарный диабет 2-го типа</kwd><kwd>ингибиторы дипептидилпептидазы-4</kwd><kwd>ситаглиптин</kwd><kwd>негликемические эффекты</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kim W., Egan J.M. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev 2008; 60 (4): 470-512.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Stonehouse A.H., Darsow T., Maggs D.G. Incretin-based therapies. J Diabetes 2012; 4 (1): 55-67.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Grieve D.J., Cassidy R.S., Green B.D. Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control? Br J Pharmacol 2009; 157 (8): 1340-1351.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Arechavaleta R., Seck T., Chen Y. et al. Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab 2011; 13 (2): 160-168</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Hong E.S., Khang A.R., Yoon J.W. et al. Comparison between sitagliptin as add-on therapy to insulin and insulin dose-increase therapy in uncontrolled Korean type 2 diabetes: CSI study. Diabetes Obes Metab 2012; 14 (9): 795-802.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Yanai H., Adachi H., Hamasaki H. et al. Effects of 6-month sitagliptin treatment on glucose and lipid metabolism, blood pressure, body weight and renal function in type 2 diabetic patients: a chart-based analysis. J Clin Med Res 2012; 4 (4): 251-258.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Öz Ö., Kıyıcı S., Ersoy C. et al. Effect of sitagliptin monotherapy on serum total ghrelin levels in people with type 2 diabetes. Diabetes Res Clin Pract 2011; 94 (2): 212-216.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Monami M., Vitale V., Ambrosio M.L. et al. Effects on Lipid Profile of Dipeptidyl Peptidase 4 Inhibitors, Pioglitazone, Acarbose, and Sulfonylureas: Meta-analysis of Placebo-Controlled Trials. Adv Ther 2012; 29 (9): 736-746.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Derosa G., Ragonesi P.D., Arrigo E.F. Sitagliptin added to previously taken anti-diabetic agents on insulin resistance and lipid profile: a two years study evaluation. Fund Clin Pharm 2012; doi:1 0.1111/fcp.12001. [Accepted 03-Sep-2012]</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Liu L., Liu J., Wong W.T. et al. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like Peptide 1-dependent mechanism. Hypertension 2012; 60 (3): 833-841.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Marney A., Kunchakarra S., Byrne L., Brown N.J. Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension 2010; 56 (4): 728-733.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Green J.B. The dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus: cardiovascular safety. Postgrad Med 2012; 124 (4): 54-61.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Ye Y., Perez-Polo J.R., Aguilar D., Birnbaum Y. The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury. Basic Res Cardiol 2011; 106 (6): 925-952.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Ye Y., Keyes K.T., Zhang C. et al. The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA. Am J Physiol Heart Circ Physiol 2010; 298 (5): H1454-1465.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Post S., van den Broek A.J., Rensing B. et al. Reduced CD26 expression is associated with improved cardiac function after acute myocardial infarction: Insights from the REPERATOR study. J Mol Cell Cardiol 2012 Sep 9. pii: S0022-2828(12)00331-8.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Theiss H.D., Brenner C., Engelmann M.G. et al. Safety and efficacy of SITAgliptin plus GRanulocyte-colony-stimulating factor in patients suffering from Acute Myocardial Infarction (SITAGRAMI-Trial) - rationale, design and first interim analysis. Int J Cardiol 2010; 145 (2): 282-284.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Gomez N., Touihri K., Matheeussen V. et al. Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure. Eur J Heart Fail 2012; 14 (1): 14-21.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Makdissi A., Ghanim H., Vora M. et al. Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab 2012; 97 (9): 3333-3341.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Ferreira L., Teixeira-de-Lemos E., Pinto F. et al. Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat). Mediators Inflamm 2010; Article ID 592760, 11 pages doi:10.1155/2010/592760.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Mega C., de Lemos E.T., Vala H. et al. Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat). Exp Diabetes Res 2011; 2011: 162092.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Gupta A.K., Verma A.K., Kailashiya J. et al. Sitagliptin: Anti-platelet effect in diabetes and healthy volunteers. Platelets 2012; 23 (8): 565-570.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Maiztegui B., Borelli M.I., Madrid V.G. et al. Sitagliptin prevents the development of metabolic and hormonal disturbances, increased Β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats. Clin Sci (Lond) 2011; 120 (2): 73-80.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Gupta N.A., Mells J., Dunham R.M. et al. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010; 51 (5): 1584-1592.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Iwasaki T., Yoneda M., Inamori M. et al. Sitagliptin as a novel treatment agent for non-alcoholic Fatty liver disease patients with type 2 diabetes mellitus. Hepatogastroenterology 2011; 58 (112): 2103-2105.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Iwasaki T., Tomeno W., Yoneda M. et al. Non-alcoholic fatty liver disease adversely affects the glycemic control afforded by sitagliptin. Hepatogastroenterology 2012; 59 (117): 1522-1555.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Garg R., Chen W., Pendergrass M. Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy clAIM: analysis. Diabetes Care 2010; 33 (11): 2349-2354.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Engel S.S., Williams-Herman D.E., Golm G.T. et al. Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis. Int J Clin Pract 2010; 64 (7): 984-990.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Chan J.C., Scott R., Ferreira A.J.C. et al. Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes Obes Metab 2008; 10 (7): 545-555.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Pendergrass M., Fenton C., Haffner S.M., Chen W. Exenatide and sitagliptin are not associated with increased risk of acute renal failure: a retrospective clAIM: analysis. Diabetes Obes Metab 2012; 14 (7): 596-600.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Penfornis A., Bourdel-Marchasson I., Quere S., Dejager S. Real-life comparison of DPP4-inhibitors with conventional oral antidiabetics as add-on therapy to metformin in elderly patients with type 2 diabetes: The HYPOCRAS study. Diabetes Metab. 2012 Sep 17. pii: S1262-3636(12)00121-8.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Salti I., Bénard E., Detournay B. et al. A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study. Diabetes Care 2004; 27 (10): 2306-2311.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Al Sifri S., Basiounny A., Echtay A. et al. The incidence of hypoglycaemia in Muslim patients with type 2 diabetes treated with sitagliptin or a sulphonylurea during Ramadan: a randomised trial. Int J Clin Pract 2011; 65 (11): 1132-1140.</mixed-citation></ref></ref-list></back></article>
