Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya31156Editorial articleПередовая статьяReview ArticleTelaprevir: New possibilities for antiviral treatment in patients with chronic hepatitis CТелапревир: новые возможности противовирусного лечения больных хроническим гепатитом СNikitinI GНикитинИ ГGogovaL MГоговаЛ МBaĭkovaI EБайковаИ ЕKisliakovV AКисляковВ АVolynkinaV MВолынкинаВ МГБОУ ВПО "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Минздравсоцразвития России, Москва151120128411VOL 84, NO11 (2012)ТОМ 84, №11 (2012)758010042020Copyright ©; 2012, Consilium MedicumCopyright ©; 2012, ООО "Консилиум Медикум"2012Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/31156

The review considers the chemical structure, pharmacodynamics and pharmacokinetics of telaprevir, a new direct-acting antiviral agent, used to treat patients with chronic hepatitis C (CHC). The given data on Phase II and III clinical trials enable the authors to state the high efficacy of the drug in patients infected with hepatitis C virus type 1. The paper also provides data on the resistance of telaprevir and its drug interaction and denotes the place of the drug in the current antiviral treatment of patients with CHC.

Аннотация. В обзоре рассматриваются химическая структура, фармакодинамика и фармакокинетика телапревира - нового препарата прямого противовирусного действия - для лечения больных хроническим гепатитом С (ХГС). Представленные данные по клиническим исследованиям II и III фазы позволяют констатировать высокую эффективность препарата у пациентов с ХГС, инфицированных вирусом гепатита С 1-го типа. В статье представлены также данные о резистентности и межлекарственном взаимодействии телапревира, обозначено его место в современном противовирусном лечении больных с ХГС.

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