Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya31143Research ArticleLong-term entecavir efficacy retention in the treatment of chronic hepatitis B with an outcome to hepatic cirrhosis caused by its resistant virus strainZnoĭkoO Oolgaznoyko@yandex.ruDudinaK R-SafiullinaN Kh-KarandashovaI V-ChulanovV P-151120128411616310042020Copyright © 2012, Consilium Medicum2012The paper gives concise data on the efficacy of entecavir in the treatment of chronic hepatitis B caused by its resistant virus strain and describes a relevant clinical case.chronic hepatitis Bhepatic cirrhosisentecavirхронический гепатит Вцирроз печениэнтекавир[EASL clinical practice guidelines: Management of chronic hepatitis B virus infection J Hepatol 2012; 57 (1): 167-185.][Tenney D.J., Rose R.E., Baldick C.J. et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy. Hepatology 2009; 49 (5): 1503-1514.]