<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31120</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Alginates in the treatment of postgastroresection reflux esophagitis</article-title><trans-title-group xml:lang="ru"><trans-title>Альгинаты при лечении постгастрорезекционного рефлюкс-эзофагита</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ianova</surname><given-names>O B</given-names></name><name xml:lang="ru"><surname>Янова</surname><given-names>О Б</given-names></name></name-alternatives><email>av8943@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kim</surname><given-names>V A</given-names></name><name xml:lang="ru"><surname>Ким</surname><given-names>В А</given-names></name></name-alternatives><email>zvopt@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Treĭman</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Трейман</surname><given-names>Е В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Центральный научно-исследовательский институт гастроэнтерологии Департамента здравоохранения Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2012</year></pub-date><volume>84</volume><issue>10</issue><issue-title xml:lang="en">VOL 84, NO10 (2012)</issue-title><issue-title xml:lang="ru">ТОМ 84, №10 (2012)</issue-title><fpage>48</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/31120">https://ter-arkhiv.ru/0040-3660/article/view/31120</self-uri><abstract xml:lang="en"><p>Aim. To evaluate the efficacy of alginates in the treatment of postgastroresection reflux esophagitis. Subjects and methods. Thirty-four post-Billroth II distal gastrectomy patients with reflux esophagitis and without erosive and ulcerative lesions of the gastric stump and anastomosis, who had received geviscon monotherapy for 6 weeks, were examined. Their symptoms and the data of esophagogastroduodenoscopy and impedance pH monitoring were assessed to control treatment results. Results. There was statistically significant relief of the subjective (heartburn and bitter taste in the mouth) and objective symptoms of the disease and the reflux esophagitis in geviscon-treated patients. Conclusion. Geviscon is the drug of choice for treating reflux esophagitis in patients after partial distal gastrectomy provided that the acid-forming function of the gastric mucosa is minimally preserved.</p></abstract><trans-abstract xml:lang="ru"><p>Резюме. Цель исследования. Оценить эффективность альгинатов при лечении постгастрорезекционного рефлюкс-эзофагита. Материалы и методы. Обследовали 34 больных после дистальной резекции желудка по Бильрот II с рефлюкс-эзофагитом и без эрозивно-язвенных поражений культи желудка и анастомоза, которые получали гевискон в виде монотерапии в течение 6 нед. Проводили оценку симптомов, результатов эзофагогастродуоденоскопии, рН/импеданс-мониторинг для контроля результатов лечения. Результаты. У больных на фоне приема гевискона отмечено статистически значимое устранение субъективных симптомов заболевания (изжога и горечь во рту), а также объективных признаков рефлюкс-эзофагита. Заключение. Гевискон является оптимальным средством для лечения рефлюкс-эзофагита у больных после частичной дистальной резекции желудка при условии минимального сохранения кислотообразующей функции слизистой оболочки желудка.</p></trans-abstract><kwd-group xml:lang="en"><kwd>reflux esophagitis</kwd><kwd>gastrectomy</kwd><kwd>alginates</kwd><kwd>geviscon</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рефлюкс-эзофагит</kwd><kwd>резекция желудка</kwd><kwd>альгинаты</kwd><kwd>гевискон</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Machida T. A study of intragastric pH in patients with peptic ulcer with special reference to the clinical significance of basal pH values. Gastroenterologia Japonica 1981; 16: 447-458.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Mann O., Glaser J., Pausch J., Rosemeyer D. Prognostic value of long-term pH-metry in the B-II resected stomach. Z Gastroenterol 1993; 31: 392-394.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Sears R., Champion G., Richter J. Characteristics of partial gastrectomy patients with esophageal symptoms of duodenogastric reflux. Am J Gastroenterol 1995; 90: 211-215.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Gillison E., Nyhus L., Bombeck C. The significanceof bile in reflux esophagitis. Surg Gvnecol Obstet 1972; 134: 419-424.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Harmon J., Johnson L., Maydonovitch C. Effects of acid and bile salts on the rabbit esophageal mucosa. Dig Dis Sci 1981; 26: 65-72.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Kivilaakso E., Fromm D., Silen W. Effect of bile salts and related compounds on isolated esophageal mucosa. Surgery 1980; 87: 280-285.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>www.fda.gov/consumer</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Марова Е.И. Классификация остеопороза. Остеопороз и остеопатии 1998; 1: 8-12.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Mellström D., Johansson C., Johnell O. et al. Osteoporosis, metabolic aberrations and increased risk for vertebral fractures after partial gastrectomy. Calcif Tissue Int 1993; 53 (6): 370-377.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Hall G., Neale G. Bone rarefaction after partial gastrectomy. Ann Intern Med 1967; 67: 1296-1330.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Lim J., Kim S., Bang H. High prevalence of osteoporosis in gastric adenocarcinoma patients after gastrectomy. World J Gastroenterol 2007; 13 (48): 6492-6497.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Berthon G. Aluminum speciation in relation to aluminum bioavailability, metabolism and toxiety. Coord Ghem Rev 2002; 228: 319-341.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Усов А.И. Альгиновые кислоты и альгинаты: методы анализа, определения состава и установления строения. Успехи химии 1999; 11: 1051-1061.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Mandel K.G., Daggy B.P., Brodie D.A. et al. Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther 2000; 14: 669-690.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Fass R. Focused clinical review: nonerosive reflux disease. Medscape Gastroenterol 2001; 3: 1-13.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Akiyma H., Endo T., Nakakita R. et al. Effect of depolymerized alginates on thegrowth of bifidobacteria. Biosci. Biotechnol. Biochem 1992; 56: 355-356.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>WangY., HanF., Hu B. et al. In vivo prebiotic properties of alginate oligosaccharides prepared through enzymatic hydrolysis of alginate. Nutrition Res 2006; 26 (11): 597-603.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Маев И.В., Овлашенко Е.А., Кучерявый Ю.А. Внешнесекреторная недостаточность поджелудочной железы у больных после оперативных вмешательств на желудке. Consilium medicum 2009; 1: 21-26.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Парфенов А.И., Бондаренко В.М. Дисбиоз кишечника и его лечение. Справочник поликлинического врача 2009; 6: 41-46.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Ардатская М.Д. Синдром избыточного бактериального роста и нарушение процессов пищеварения и всасывания. Поликлиника 2009; 2: 38-40.</mixed-citation></ref></ref-list></back></article>
