Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya31037Research ArticleREMODELING OF CARDIOVASCULAR SYSTEM AND DEVELOPMENT OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH METABOLIC SYNDROME AND OBESITY: ROLE OF GENES ENOS, SUBUNIT P22-PHOX OF NADPH-OXIDASE AND MTHFRSaginovaE AChair of Therapy and Occupational Diseases of Medicoprophylactic Departmentmed02@yandex.ruGallyamovM GChair of Internal Medicine of Fundamental Medicine Department-BalatskyA VChair of Biochemistry and Molecular Medicine of Fundamental Medicine Department-KolotvinA VChair of Biochemistry and Molecular Medicine of Fundamental Medicine Department-SeverovaM VChair of Therapy and Occupational Diseases of Medicoprophylactic Department-SamokhodskayaL MLaboratory of Gene and Cell Technology of Fundamental Medicine Department-FominV VChair of Therapy and Occupational Diseases of Medicoprophylactic Department-KrasnovaT NChair of Internal Medicine of Fundamental Medicine Department-MukhinN AChair of Therapy and Occupational Diseases of Medicoprophylactic Department-I.M. Sechenov First Moscow State Medical UniversityM.V. Lomonosov Moscow State University15062012846263110042020Copyright © 2012, Consilium Medicum2012Aim. To examine contribution of polymorphisms of genes of endothelial NO-synthase (eNOS), NADPH-oxidase and methylenetetrahydrofolate reductase (mTHFR) to development of remodeling of cardiovascular system and chronic disease of the kidneys (CDK) in patients with metabolic syndrome (mS) and obesity. Material and methods. Standard clinical and device examinations were made and polymorphisms C242T of gene of subunit p22-phox of NADPH-oxidase, G894T of gene of eNOS and C677T of gene of MTHFR were studied in 66 MS patients (49 males and 17 females, age 19-62 years. Results. The presence of even one prognostically poor allele variants of the genes studied was registered in 83 examinees. The genotype 242TT p22-phox of NADPH-oxidase subunit was associated with the highest insulin resistance, allele 894T of gene eNOS - with reduced glomerular filtration rate and progression of left ventricular hypertrophy. Conclusion. Polymorphism of the genes the products of which modulate endothelial function can be considered as potential predictors of severity of MS target organs impairment.obesitymetabolic syndromechronic kidney diseaseleft ventricular hypertrophyeNOS genegene of NADPH-oxidaseMTHFR geneожирениеметаболический синдромхроническая болезнь почекгипертрофия левого желудочкаген eNOSген субъединицы p22-phox NADPH-оксидазыген MTHFR[Чазова И. Е., Мычка В. Б. Метаболический синдром. М.: Медиа Медика; 2004.][Kerr S.M., Livingstone M.B., McCrorie T.A., Wallace J.M. Endothelial dysfunction associated with the obesity and the effect of weight loss interventions. Proc.Nutr. Soc. 2011; 70 (4): 418—425.][Blanquicett C., Graves A., Kleinhenz D. J., Hart C. M. 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