Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30948Editorial articleПередовая статьяHypogonadism and cardiovascular diseases in menГипогонадизм и сердечно-сосудистые заболевания у мужчинGamidovSafail OglyГамидовСафаил Оглы

д-р мед. наук, проф. каф. урологии РГМУ им. Н. И. Пирогова, проф. каф. акушерства, гинекологии, перинатологии и репродуктологии ФППОВ Первого МГМУ им. И. М. Сеченова; ГОУ ВПО Российский государственный медицинский университет им. Н. И. Пирогова Росздрава; ГОУ ВПО Первый Московский государственный медицинский университет им. И. М. Сеченова Росздрава

docand@rambler.ruTazhetdinovOleg KhalitovichТажетдиновОлег Халитович

аспирант каф. урологии РГМУ им. Н. И. Пирогова; ГОУ ВПО Российский государственный медицинский университет им. Н. И. Пирогова Росздрава

IremashviliVyacheslav Vasil'evichИремашвилиВячеслав Васильевич

канд. мед. наук, сотр. каф. урологии РГМУ им. Н. И. Пирогова; ГОУ ВПО Российский государственный медицинский университет им. Н. И. Пирогова Росздрава

GamidovS I

N.I. Pirogov Russian State Medical University, Moscow; I.M. Sechenov First Moscow State Medical University

TazhetdinovO Kh

N.I. Pirogov Russian State Medical University, Moscow

IremashviliV V

N.I. Pirogov Russian State Medical University, Moscow

ГОУ ВПО Российский государственный медицинский университет им. Н. И. Пирогова РосздраваГОУ ВПО Первый Московский государственный медицинский университет им. И. М. Сеченова РосздраваГОУ ВПО Российский государственный медицинский университет им. Н. И. Пирогова РосздраваГОУ ВПО Российский государственный медицинский университет им. Н. И. Пирогова РосздраваN.I. Pirogov Russian State Medical University, MoscowI.M. Sechenov First Moscow State Medical UniversityN.I. Pirogov Russian State Medical University, Moscow151020118310NO10 (2011)ТОМ 83, №10 (2011)616710042020Copyright ©; 2011, Consilium MedicumCopyright ©; 2011, ООО "Консилиум Медикум"2011Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30948

The article analyses correlation between low levels of sex hormones in men (male hypogonadism) and cardiovascular diseases. It was believed for a long time that androgens have adverse effect on cardiovascular system. It is shown that, on the contrary, hypogonadism indirectly raises the risk of cardiovascular diseases via various components of metabolic syndrome. Moreover, correction of male hypogonadism with testosterone preparations may have a positive effect on risk factors of vascular complications including fat reduction , normalization of blood pressure, correction of dyslipidemia. Pharmacologically, testosterone undecanoate for intramuscular injections (nebido) is a good form. This drug can provide a stable physiological testosterone level for about 12 weeks after injection.

В работе рассмотрены вопросы взаимосвязи между снижением уровня половых гормонов у мужчин (мужской гипогонадизм) и сердечно-сосудистыми заболеваниями. Вопреки существовавшим на протяжении длительного времени взглядам, андрогены не оказывают неблагоприятного действия на сердечно-сосудистую систему. Напротив, гипогонадизм повышает риск развития заболеваний сердца и сосудов, вероятнее всего, опосредованно, через различные компоненты метаболического синдрома. Более того, коррекция мужского гипогонадизма путем применения препаратов тестостерона в ряде случаев сопровождается благоприятным влиянием на факторы риска развития сосудистых осложнений, включая снижение объема жировой ткани, нормализацию артериального давления и, возможно, устранение дислипидемии. Одной из наиболее удобных фармакологических форм тестостерона является тестостерона ундеканоат для внутримышечного введения (небидо). Данный препарат имеет уникальные характеристики, обеспечивая стабильный уровень тестостерона в пределах физиологических значений в течение около 12 нед после введения.

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