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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">30919</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Progress in gene therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Успехи генной терапии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Glazkova</surname><given-names>Dina Viktorovna</given-names></name><name xml:lang="ru"><surname>Глазкова</surname><given-names>Дина Викторовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. биол. наук, науч. сотр., ЦНИИ эпидемиологии, тел. : 8-495-305-54-23; ФГУ ЦНИИ эпидемиологии Роспотребнадзора</p></bio><email>glazkova@pcr.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bogoslovskaya</surname><given-names>Elena Vladimirovna</given-names></name><name xml:lang="ru"><surname>Богословская</surname><given-names>Елена Владимировна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ст. науч. сотр. ЦНИИ эпидемиологии; ФГУ ЦНИИ эпидемиологии Роспотребнадзора</p></bio><email>lenabo@pcr.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shipulin</surname><given-names>German Aleksandrovich</given-names></name><name xml:lang="ru"><surname>Шипулин</surname><given-names>Герман Александрович</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, зав. отд. молекулярной диагностики и эпидемиологии; ФГУ ЦНИИ эпидемиологии Роспотребнадзора</p></bio><email>german@pcr.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pokrovskiy</surname><given-names>Valentin Ivanovich</given-names></name><name xml:lang="ru"><surname>Покровский</surname><given-names>Валентин Иванович</given-names></name></name-alternatives><bio xml:lang="ru"><p>акад. РАМН, дир. ЦНИИ эпидемиологии; ФГУ ЦНИИ эпидемиологии Роспотребнадзора</p></bio><email>info@pcr.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Glazkova</surname><given-names>D V</given-names></name><bio xml:lang="en"><p>Central Research Institute of Epidemiology, Moscow</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Bogoslovskaya</surname><given-names>E V</given-names></name><bio xml:lang="en"><p>Central Research Institute of Epidemiology, Moscow</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Shipulin</surname><given-names>G A</given-names></name><bio xml:lang="en"><p>Central Research Institute of Epidemiology, Moscow</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Pokrovsky</surname><given-names>V I</given-names></name><bio xml:lang="en"><p>Central Research Institute of Epidemiology, Moscow</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГУ ЦНИИ эпидемиологии Роспотребнадзора</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central Research Institute of Epidemiology, Moscow</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2011</year></pub-date><volume>83</volume><issue>8</issue><issue-title xml:lang="en">NO8 (2011)</issue-title><issue-title xml:lang="ru">ТОМ 83, №8 (2011)</issue-title><fpage>62</fpage><lpage>69</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/30919">https://ter-arkhiv.ru/0040-3660/article/view/30919</self-uri><abstract xml:lang="en"><p>Recent progress in gene therapy, current status of investigations in this area of experimental medicine are reviewed. Much attention is given to gene-therapeutic approaches the efficacy of which is proved in clinical trials.</p></abstract><trans-abstract xml:lang="ru"><p>Обзор посвящен успехам, достигнутым в последние годы в генной терапии. Обсуждается современное состояние исследований в данной области экспериментальной медицины. Основное внимание уделено генотерапевтическим подходам, эффективность которых показана в клинических испытаниях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>review</kwd><kwd>gene therapy</kwd><kwd>gene delivery</kwd><kwd>transgene</kwd><kwd>vectors</kwd><kwd>clinical trials</kwd><kwd>congenital immunodeficiencies</kwd><kwd>severe combined immunodeficiency</kwd><kwd>Leber's amavrosis</kwd><kwd>adrenoleukodystrophy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>генная терапия</kwd><kwd>доставка генов</kwd><kwd>трансген</kwd><kwd>векторы</kwd><kwd>клинические испытания</kwd><kwd>врожденные иммунодефициты</kwd><kwd>ТКИД (тяжелый комбинированный иммунодефицит)</kwd><kwd>амавроз Лебера</kwd><kwd>адренолейкодистрофия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Breakthrough of the year. The runners-up. 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