Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30879Editorial articleПередовая статьяEfficacy of pharmacological inhibition of intestinal saccharases in patients with diabetes mellitus type 2 and/or visceral obesityЭффективность фармакологического ингибирования интестинальных сахараз у пациентов с сахарным диабетом 2-го типа и/или висцеральным ожирениемAmetovAleksandr SergeevichАметовАлександр Сергеевич

д-р мед. наук, проф., зав. каф. эндокринологии и диабетологии с курсом эндокринной хирургии РМАПО; РМАПО

KamyninaLyudmila LeonidovnaКамынинаЛюдмила Леонидовна

врач-эндокринолог, аспирант каф. эндокринологии и диабетологии с курсом эндокринной хирургии РМАПО, тел.: 8-495-490-01-14; РМАПО

petrology@yandex.ruAmetovA S

Russian Medical Academy of Postgraduate Education, Moscow

KamyninaL L

Russian Medical Academy of Postgraduate Education, Moscow

РМАПОRussian Medical Academy of Postgraduate Education, Moscow15052011835NO5 (2011)ТОМ 83, №5 (2011)768010042020Copyright ©; 2011, Consilium MedicumCopyright ©; 2011, ООО "Консилиум Медикум"2011Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30879

Inhibitors of intestinal enzymes regulate carbohydrate metabolism reducing glycemic index, glycemic load of food and postprandial glycemia which is a prognostic factor of DM2-related cardiovascular complications and death. This class of drugs was proposed for DM2 treatment in 1970s but still holds perspectives. The article gives a detailed description of the mechanism of action, efficacy and safety of inhibitors of alpha-glucosidase and alpha-amilase in experimental and clinical controlled trials.

Несмотря на многообразие классов сахароснижающих препаратов, применяемых при сахарном диабете 2-го типа (СД2), в настоящее время перспективным остается использование предложенных еще в 70-е годы XX в. ингибиторов интестинальных ферментов, влияющих на углеводный обмен. Препараты данного класса, уменьшая гликемический индекс и гликемическую нагрузку пищевых продуктов, снижают постпрандиальную гликемию - основного прогностического фактора развития сердечно-сосудистых осложнений и смертности при СД2. Подробно рассмотрены механизм действия, эффективность и безопасность применения ингибиторов α-глюкозидазы и α-амилазы в экспериментальных и клинических контролируемых исследованиях.

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