Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30875Editorial articleПередовая статьяOptimization of the control of blood pressure. What contribution can be obtained from use of combinations of fixed doses of ACE inhibitors and calcium channel blockers?Оптимизация контроля уровня артериального давления. Какой вклад может дать применение комбинаций фиксированных доз ингибиторов ангиотензинпревращающего фермента и блокаторов кальциевых каналов?EliseevOleg MaksimovichЕлисеевОлег Максимович

вед. науч. сотр. РКНПК, тел.: 8-495-414-65-60; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

dubrovo@list.ruEliseevO M

Cardiological Research Center, Moscow

ФГУ Российский кардиологический научно-производственный комплекс РосмедтехнологийCardiological Research Center, Moscow15052011835NO5 (2011)ТОМ 83, №5 (2011)707510042020Copyright ©; 2011, Consilium MedicumCopyright ©; 2011, ООО "Консилиум Медикум"2011Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30875

Basing on the results of large trials investigating efficacy of combined use of angiotensin-converting enzyme inhibitors (as a rule, perindopril) and calcium channel blockers (as a rule, amlodipin), the article analyses variety of mechanisms of their combined action, effects on dynamics of blood pressure, heart rate variability. The above combined treatment significantly reduces frequency of cardiovascular complications, improves the course of diabetes mellitus in its combination with arterial hypertension, renal function in patients with chronic renal failure and arterial hypertension. It is important to use fixed doses of the above drugs.

В обзоре на основании материалов ряда крупных исследований, в которых исследовалась эффективность сочетанного применения ингибиторов ангиотензинпревращающего фермента (преимущественно периндоприла) и блокаторов кальциевых каналов (преимущественно амлодипина), дается анализ многообразных механизмов их сочетанного действия, влияния на динамику артериального давления, вариабельность ритма сердца. Под влиянием комбинированной терапии отмечаются значительное снижение частоты развития сердечно-сосудистых осложнений, улучшение течения сахарного диабета при сочетанном течении его с артериальной гипертонией, а также улучшение функции почек у больных с хронической почечной недостаточностью и артериальной гипертонией. Подчеркивается важная роль применения лекарственных форм, содержащих фиксированные дозы этих препаратов.

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