Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30865Editorial articleПередовая статьяDevelopment of aceptic osteonecrosis during the treatment of acute lymphoblastic leukemia: review of the literature and original dataРазвитие асептического остеонекроза на фоне терапии острого лимфобластного лейкоза: обзор литературы и собственное наблюдениеBaranovaOl'ga Yur'evnaБарановаОльга Юрьевна

Отделение химиотерапии гемобластозов- канд. мед. наук, ст. науч. сотр, тел.: 8-499-472-93-65; Российский онкологический научный центр им. Н. Н. Блохина РАМН

baranova-crc@mail.ruShirinAnton DmitrievichШиринАнтон Дмитриевич

Отделение химиотерапии гемобластозов- канд. мед. наук, ст. науч. сотр; Российский онкологический научный центр им. Н. Н. Блохина РАМН

FalaleevaNatal'ya AleksandrovnaФалалееваНаталья Александровна

Отделение химиотерапии гемобластозов- канд. мед. наук, врач; Российский онкологический научный центр им. Н. Н. Блохина РАМН

OsmanovEvgeniy AleksandrovichОсмановЕвгений Александрович

Отделение химиотерапии гемобластозов- д-р. мед. наук, проф., зав. отд-нием химиотерапии гемобластозов; Российский онкологический научный центр им. Н. Н. Блохина РАМН

BaranovaO Yu

N.N. Blokhin Russian Cancer Research Center, Moscow

ShirinA D

N.N. Blokhin Russian Cancer Research Center, Moscow

FalaleevaN A

N.N. Blokhin Russian Cancer Research Center, Moscow

OsmanovD Sh

N.N. Blokhin Russian Cancer Research Center, Moscow

Российский онкологический научный центр им. Н. Н. Блохина РАМНN.N. Blokhin Russian Cancer Research Center, Moscow15072011837NO7 (2011)ТОМ 83, №7 (2011)263210042020Copyright ©; 2011, Consilium MedicumCopyright ©; 2011, ООО "Консилиум Медикум"2011Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30865

We report a case of aceptic osteonecrosis (AON) of the left hymerus epiphysis in programmed treatment of a male patient with lymphoblastic lymphoma to illustrate clinical, laboratory, epidemiological, pathogenetic, diagnostic and therapeutic aspects of AON in programmed therapy of acute lymphoblastic leukemia (ALL). We believe that AON is a rather frequent but often missed for early diagnosis complication of ALL treatment. Even a weak pain in bones and joints under mechanical load in patients on long-term treatment with glucocorticosteroids is an alarming symptom which may indicate a risk of an osteodestructive process and relevant diagnostic and therapeutic measures may be needed.

В целях демонстрации клинико-лабораторных особенностей, вопросов эпидемиологии, патогенеза, диагностики и лечения асептического остеонекроза (АОН) при программной терапии острых лимфобластных лейкозов (ОЛЛ) приведено клиническое наблюдение АОН эпифиза левой плечевой кости при программном лечении больного с лимфобластной лимфомой. Сделан вывод, что АОН является достаточно частым, но не всегда своевременно диагностируемым осложнением терапии ОЛЛ. Даже появление незначительного болевого синдрома в костях или суставах, подверженных механической нагрузке, у пациентов, которые получают длительную терапию глюкокортикостероидами, должно настораживать в отношении риска развития остеодеструктивного процесса и обусловливают необходимость проведения комплекса лечебно-диагностических мероприятий.

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