Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30862Editorial articleПередовая статьяMain factors of gender dimorphism of gout (estrogens and diuretics vs alcohol and genetics)Основные факторы полового диморфизма подагры (эстрогены и диуретики по сравнению с алкоголем и генетикой)BarskovaViktoriya GeorgievnaБарсковаВиктория Георгиевна

д-р мед. наук, проф., рук. лаб. микрокристаллических артритов НИИР РАМН; Научно-исследовательский институт ревматологии РАМН

barskova@irramn.ruEliseevMaksim SergeevichЕлисеевМаксим Сергеевич

канд. мед. наук, ст. науч. сотр. лаб. микрокристаллических артритов НИИР РАМН; Научно-исследовательский институт ревматологии РАМН

elicmax@rambler.ruChikalenkovaNailya AlekperovnaЧикаленковаНаиля Алекперовна

врач-ревматолог Главного военного клинического госпиталя внутренних войск МВД РФ; Главный военный клинический госпиталь внутренних войск МВД РФ

nailygaaskerova@mail.ruBarskovaV G

Research Institute of Rheumatology, AMS, Moscow

EliseevM S

Research Institute of Rheumatology, AMS, Moscow

ChikalenkovaN A

Central hospital of the Ministry of Internal Affairs, Moscow

Научно-исследовательский институт ревматологии РАМНГлавный военный клинический госпиталь внутренних войск МВД РФResearch Institute of Rheumatology, AMS, MoscowCentral hospital of the Ministry of Internal Affairs, Moscow15052011835NO5 (2011)ТОМ 83, №5 (2011)576110042020Copyright ©; 2011, Consilium MedicumCopyright ©; 2011, ООО "Консилиум Медикум"2011Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30862

The article analyses factors underling gender dimorphism of gout, gender epidemiological differences. Discussion covers the role of estrogens and menopause, alcohol, diuretics, gender-associated genetic characteristics in gout genesis.

Статья посвящена анализу факторов, лежащих в основе полового диморфизма подагры. Подробно изложены связанные с полом эпидемиологические различия. Обсуждена роль эстрогенов и менопаузы, алкоголя, мочегонных препаратов и ассоциированных с полом генетических особенностей в генезе подагры.

goutgout in womenuric acidhyperuricemiaподаграподагра у женщинмочевая кислотагиперурикемияНасонова В. А., Барскова В. Г. Ранние диагностика и лечение подагры - научно обоснованное требование улучшения трудового и жизненного прогноза больных. Науч.-практ. ревматол. 2004; 1: 5-7.Adams P. F., Hendershot G. E., Marano M. A. Current estimates from the National Health Interview Survey, 1996. - Vital Health Stat 10, 1999.Lawrence R. C., Helmick C. G., Arnett F. C. et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthr. and Rheum. 1998; 41: 778- 799.Saag K. G., Mikuls T. R. Recent advances in the epidemiology of gout. Curr. Rheumatol. Rep. 2005; 7: 235-241.Roubenoff R., Klag M. J., Mead L. A. et al. Incidence and risk factors for gout in white men. J. A. M. A. 1991; 266: 3004- 3007.Terkeltaub R. A. Clinical practice. Gout. N. Engl. J. Med. 2003; 349: 1647-1655.Wallace K. L., Riedel A. A., Joseph-Ridge N., Wortmann R. Increasing prevalence of gout and hyperuricemia over 10 years among older adult in a managed care population. J. Rheumatol. 2004; 31: 1582-1587.Kramer H. M., Curhan G. The association between gout and nephrolitiasis: the National and Nutrition Examination Survey III, 1988-1994. Am. J. Kidney Dis. 2002; 40: 37-42.Annemans L., Spaepen E., Gaskin M. et al. Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005. Ann. Rheum. Dis. 2008; 67: 960-966.Arromdee E., Michet C. J., Crowson C. S. et al. Epidemiology of gout: Is the incidence rising? J. Rheumatol. 2002; 29: 2403-2406.Bhole V., de Vera M., Rahman M. M., Krishnan E., Choi H. Epidemiology of gout in women: Fifty-two-year followup of a prospective cohort. Arthr. and Rheum. 2010; 62(4): 1069- 1076.Campion E. W., Glynn R. J., DeLabry L. O. Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am. J. Med. 1987; 82: 421-426.Lally E. V., Ho G., Kaplan S. R. The clinical spectrum of gouty arthritis in women. Arch. Intern. Med. 1986; 146(11): 2221-2225.ALLHAT officers and Coordinators for the ALLHAT Collaborative Research Group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to preventheart attack trial (ALLHAT). J. A. M. A. 2000; 283: 1967-1975.Chobanian A. V., Bakris G. L., Black H. R. et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. J. A. M. A. 2003; 289: 2560-2572.Lin K. C., Lin H. Y., Chou P. The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J. Rheumatol. 2000; 27: 1501-1505.St. Onge M. P., Keller K. L., Heymsfield S. B. Changes in childhood food consumption patterns - a cause for concern in light of increasing body weight. Am. J. Clin. Nutr. 2003; 78: 1068-1073.Bieber J. D., Terkeltaub R. A. Gout. On the brink of a novel therapeutic options for an ancient disease. Arthr. and Rheum. 2004; 50: 2400-2414.Reyes D., Lew S. Q., Kimmel P. L. Gender differences in hypertension and kidney disease. Med. Clin. N. Am. 2005; 89: 613-630.Harrold L. R., Yood R., Mikuls T. R. et al. Sex differences in gout epidemiology: evaluation and treatment. Ann. Rheum. Dis. 2006; 65(10): 1368-1372.Nicholls A., Scott J. T. Effect of weight-loss on plasma and urinary levels of uric acid. Lancet 1972; 2: 1223-1224.Sumino H., Ichikawa S., Kanda T. et al. Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia. Lancet 1999; 354: 650.Nicholls A., Snaith M. L., Scott J. T. Effect of oestrogen therapy on plasma and urinary levels of uric acid. Br. Med. J. 1973; 1: 449-451.Simon J. A., Lin F., Vittinghoff E., Bittner V. The relation of postmenopausal hormone therapy to serum uric acid and the risk of coronary heart disease events: the heart and estrogen-Progestin replacement Study (HERS). Ann. Epidemiol. 2006; 16: 138-145.Mikkelsen W. M., Dodge H. J., Valkenburg H. The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia: Tecumseh, Michigan, 1959-1960. Am. J. Med. 1965; 39: 242-251.Strasaak A. M., Kelleher C. C., Brant L. J. et al. Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study. Int. J. Cardiol. 2008; 125: 232-239.Hak A. E., Choi H. K. Menopause, postmenopausal hormone use and serum uric acid levels in US women - The Third National Health and Nutrition Examination Survey. Arthr. Res. Ther. 2008; 10(5): R116.Choi H. K., Curhan G. Beer, liquor, wine and serum uric acid level -- the Third National Health and Nutrition Examination Survey. Arthr. and Rheum. 2004; 51(6): 1023-1029.Sharpe C. R. A case-control study of alcohol consumption and drinking behavior on patients with acute gout. Can. Med. Assoc. J. 1984; 131: 563-567.Drum D. E., Goldman P. A., Jankowski C. B. Elevation of serum uric acid as a clue to alcohol abuse. Arch. Intern. Med. 1981; 141: 477-479.Faller J., Fox I. H. Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover. N. Engl. J. Med. 1982; 307: 1598-1602.Puig J. G., Fox I. H. Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate. J. Clin. Invest. 1984; 74: 936-941.Eastmond C. J., Garton M., Robins S., Riddoch S. The effects of alcoholic beverages on urate metabolism in gout sufferers. Br. J. Rheumatol. 1995; 34: 756-759.Gibson T., Rodgers A. V., Simmonds H. A., Toseland P. Beer drinking and its effect on uric acid. Br. J. Rheumatol. 1984; 23: 203-209.Halla J. T., Ball G. V. Saturnine gout: a review of 42 patients. Semin. Arthr. and Rheum. 1982; 11: 307-314.Lin J. L., Huang P. T. Body lead stores and urate excretion in men with chronic renal disease. J. Rheumatol. 1994; 21: 705- 709.Kaneko K., Fujimori S., Akaoka I. Changes caused by ethanol intake on metabolism of hypouricemic agents (combination of allopurinol and benzbromarone). Adv. Exp. Med. Biol. 1991; 309: 139-142.Ralston S. H., Calpell H. A., Sturrock R. D. Alcohol and response to treatment of gout. Br. Med. J. 1988; 296: 1641- 1642.Puig J. G., Michan A. D., Jimenez M. L. et al. Female gout. Clinical spectrum and uric acid metabolism. Arch. Intern. Med. 1991; 51(4): 726-732.Snaith M. Gout and alcohol. Rheumatology 2004; 43: 1208- 1209.Rehm J., Greenfield T. K., Rogers J. D. Average volume of alcohol consumption, pattern of drinking, and all-cause mortality: results from the US National Alcohol Survey. Am. J. Epidemiol. 2001; 153: 64-71.Holman C. D., English D. R., Milne E., Winter M. G. Meta-analysis of alcohol and all-cause mortality: a validation of NHMRC recommendations. Med. J. Aust. 1996; 164: 141-145.Snow W. M., Murray R., Ekuma O. et al. Alcohol use and cardiovascular health, outcomes: a comparison across age and gender in the Winnipeg health and drinking survey cohort. Age and Ageing 2009; 38: 206-212.Hall A. P., Barry P. E., Dawber T. R. et al. Epidemiology of gout and hyperuricemia: A long-term population study. Am. J. Med. 1967; 42: 27-37.American Heart Association. 2002 Heart and stroke statistical update. Dallas, Texas: American Heart Association; 2001.Turner R. E., Frank M. J., Van Ausdal D. et al. Some aspects of the epidemiology of gout. Arch. Intern. Med. 1960; 106: 400-406.Williamson J., Chopin J. M. Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age and Ageing 1980; 9: 73-80.van Kraaij D. J. W., Jansen R. W., de Gier J. J. et al. Prescription patterns of diuretics in Dutch community-dwelling elderly patients. Br. J. Clin. Pharmacol. 1998; 46: 403-407.Nath S. D., Voruganti V. S., Arar N. H. et al. Genome scan for determinants of serum uric acid variability. J. Am. Soc. Nephrol. 2007; 18: 3156-3163.Yang Q., Guo C. Y., Cupples I. A. et al. Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart study. Metabolisms 2005; 54: 1435-1441.Terkeltaub R., Bushinsky D. A., Becker M. A. Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. Arthr. Res. Ther. 2006; 8(Suppl. 1): S4.Mount D. B., Kwon C. Y., Zandi-Nejad K. Renal urate transport. Rheum. Dis. Clin. N. Am. 2006; 32: 313-331.Anzai N., Kanai Y., Endou H. New insights into renal transport of urate. Curr. Opin. Rheumatol. 2007; 19: 151-157.Graessler J., Graessler A., Unger S. et al. Association of the human urate transporter 1 with redued renal uric acid excretion and hyperuricemia in a German Caucasian population. Arthr. and Rheum. 2006; 54: 292-300.Vazquez-Mellado J., Jimenez-Vaca A. L., Cuevas-Covarrubias S. et al. Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout. Rheumatology (Oxford) 2007; 46: 215-219.Ichida K., Hosoamada M., Hisatome I. et al. Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. J. Am. Soc. Nephrol. 2004; 15: 164-173.Augustin R., Carayannopoulos M. O., Dowd L. O. et al. Identification and characterization of human glucose transporter-like protein-9 (GLUT-9): alternative slicing alters trafficking. J. Biol. Chem. 2004; 279: 16229-16236.Brandstatter A., Kleichl S., Kollerits B. et al. Sex-Specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI. Diabet. Care 2008; 31(8): 1662-1667.