Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30856Editorial articleПередовая статьяSome aspects of pathogenesis of ankylosing spondylitisНекоторые аспекты патогенеза анкилозирующего спондилитаErdesShandorЭрдесШандор

д-р мед. наук, проф., зам. дир. по научной работе, зав. лаб. серонегативных спондилоартритов, тел.: 8-499-614-44-86; Научно-исследовательский институт ревматологии РАМН

erdes@irramn.ruErdesSh

Research Institute of Rheumatology of the Academy of Medical Sciences, Moscow

Научно-исследовательский институт ревматологии РАМНResearch Institute of Rheumatology of the Academy of Medical Sciences, Moscow15052011835NO5 (2011)ТОМ 83, №5 (2011)515610042020Copyright ©; 2011, Consilium MedicumCopyright ©; 2011, ООО "Консилиум Медикум"2011Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30856

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease of the spine (spondylitis) and sacroiliac joints (sacroileitis) associated in many cases with inflammatory affection of the peripheral joints (arthritis), entesises (entesitis), eyes (uveitis), intestine (enteritis) and aortic root (aortitis). AS is considered now as a prototype of diseases from the group of seronegative spondyloarthritis. AS is a hereditary disease. Predisposition to AS (90%) is associated with genetic factors the key gene of which is HLA-B27. As pathogenesis of AS is not still verified, three hypotheses are considered basing on HLA-B27 biology.The role of environmental factors involved in AS development (tension in enteses and infection) are discussed.

Анкилозирующий спондилит (АС) - хроническое воспалительное ревматическое заболевание позвоночника (спондилит) и крестцово-подвздошных суставов (сакроилеит), нередко сочетающееся с воспалительными поражениями периферических суставов (артрит), энтезисов (энтезит), а также в ряде случаев - глаз (увеит), кишечника (энтерит) и корня аорты (аортит). В настоящее время АС рассматривают в качестве прототипа заболеваний, входящих в группу серонегативных спондилоартритов. АС - наследственное заболевание, предрасположенность к которому практически на 90% определяется генетическими факторами, в качестве ключевого гена этой предрасположенности рассматривается HLA-B27. В связи с тем что до сих пор не существует единой общепризнанной теории патогенеза АС, рассмотрены 3 гипотезы, в основе которых лежат данные о биологии HLA-B27. Обсуждаются также возможные внешнесредовые факторы, участвующие в развитии АС, - напряжение в энтезах и инфекции.

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